Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation

Journal of Biological Chemistry

Volumn 275, Issue 20, 2000, Pages 15265-15270

  Argiriadi, Maria A ^a   Morisseau, Christophe ^b   Goodrow, Marvin H ^b   Dowdy, Deanna L ^b   Hammock, Bruce D ^b   Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPOXIDE HYDROLASE; EPOXIDE HYDROLASE INHIBITOR; N CYCLOHEXYL N' (4 IODOPHENYL)UREA; N CYCLOHEXYL N' DECYLUREA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITOR INTERACTION; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; HYDROLYSIS; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BACTERIAL TOXINS; BINDING SITES; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; EPOXIDE HYDROLASES; EXOTOXINS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; TYROSINE; UREA;

ANIMALIA; MURINAE;

EID: 0034686018     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M000278200     Document Type: Article

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