Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons

Journal of Neuroscience

Volumn 18, Issue 18, 1998, Pages 7256-7271

  Vicario Abejón, Carlos ^a   Collin, Carlos ^a   McKay, Ronald D G ^a   Segal, Menahem ^b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

BDNF; Culture; GABA; Hippocampus; NT 3; Synapses

Indexed keywords

4 AMINOBUTYRIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN; NEUROTROPHIN 3;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; HIPPOCAMPUS; NERVE CELL DIFFERENTIATION; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SYNAPTOGENESIS;

EID: 0032530675     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-18-07256.1998     Document Type: Article

References (22)

1. Alcántara S, Frisén J, del Río J, Soriano E, Barbacid M, Silos-Santiago I (1997) TrkB signalling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell dead. J Neurosci 15:3623-3633.
2. Altman J, Bayer S (1990) Prolonged sojourn of developing pyramidal cells in the intermediate zone of the hippocampus and their settling in the stratum pyramidale. J Comp Neurol 301:343-364.
3. Basarsky T, Parpura V, Haydon P (1994) Hippocampal synaptogenesis in cell culture: developmental time course of synapse formation, calcium influx, and synaptic protein distribution. J Neurosci 14:6402-6411.
4. A, NMDA and AMPA receptors: a developmentally regulated "ménage a trois." Trends Neurosci 20:523-529.
5. Burns M, Augustine G (1995) Synaptic structure and function: dynamic organization yields architectural precision. Cell 83:187-194.
6. Cabelli R, Hohn A, Shatz C (1995) Inhibition of ocular dominance column formation by infusion of NT-4/5 or BDNF. Science 267:1662-1666.
7. Cabelli R, Shelton D, Segal R, Shatz C (1997) Blockade of endogenous ligands of TrkB inhibits formation of ocular dominance columns. Neuron 19:63-76.
8. Causing CG, Gloster A, Aloyz R, Bamji SX, Chang E, Fawcett, J, Kuchel G, Miller, FD (1997) Synaptic innervation density is regulated by neuron-derived BDNF. Neuron 18:257-267.
9. Collazo D, Takahashi H, McKay RDG (1992) Cellular targets and trophic functions of neurotrophin-3 in the developing rat hippocampus. Neuron 9:643-656.
10. Craig AM, Blackstone CD, Huganir RL, Banker G (1993) The distribution of glutamate receptors in cultured rat hippocampal neurons: postsynaptic clustering of AMPA-selective subunits. Neuron 10:1055-1068.
11. Figurov A, Pozzo-Miller L, Olafsson P, Wang T, Lu B (1996) Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 381:706-709.
12. Fletcher T, DeCamilli P, Banker G (1994) Synaptogenesis in hippocampal cultures: evidence indicating that axons and dendrites become competent to form synapses at different stages of neuronal development. J Neurosci 14:6695-6706.
13. Fryer R, Kaplan D, Feinstein S, Radeke M, Grayson D, Kromer L (1996) Developmental and mature expression of full-length and truncated trkB receptors in the rat forebrain. J Comp Neurol 374:21-40.
14. Geppert M, Goda Y, Stevens C, Sudhof T (1997) The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion. Nature 387:810-814.
15. Ghosh A, Greenberg M (1995) Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis. Neuron 15:89-103.
16. Greengard P, Valtorta F, Czernik AJ, Benfenati F (1993) Synaptic vesicle phosphoproteins and regulation of synaptic function. Science 259:780-785.
17. Hall Z, Sanes J (1993) Synaptic structure and development: the neuromuscular junction. Cell 72:99-121.
18. Harris K, Kater S (1994) Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic function. Annu Rev Neurosci 17:341-371.
19. Hirling H, Scheller R (1996) Phosphorylation of synaptic vesicle proteins: modulation of the aSNAP interaction with the core complex. Proc Natl Acad Sci USA 93:11945-11949.
20. Hume R, Role L, Fischbach G (1983) Acetylcholine release from growth cones detected with patches of acetylcholine receptor-rich membranes. Nature 305:632-634.
21. Jovanovic J, Benfenati F, Siow Y, Sihra T, Sanghera J, Pelech S, Greengard P, Czernik A (1996) Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions. Proc Natl Acad Sci USA 93:3679-3683.
22. Kang H, Schuman E (1995) Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 267:1658-1662.