Influence of Permeant Ions on Voltage Sensor Function in the Kv2.1 Potassium Channel

Journal of General Physiology

Volumn 123, Issue 4, 2004, Pages 387-400

  Consiglio, Joseph F ^a   Korn, Stephen J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Activation; Conformational change; Gating currents; Outer vestibule; Selectivity filter

Indexed keywords

POTASSIUM CHANNEL; POTASSIUM ION; RUBIDIUM;

ARTICLE; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; ION CONDUCTANCE; ION CURRENT; ION TRANSPORT; POTASSIUM CHANNEL KV2.1; PROTEIN CONFORMATION; RECEPTOR OCCUPANCY; SENSOR; VESTIBULE; VOLTAGE CLAMP; VOLTAGE SENSOR;

CELL LINE; HUMANS; ION CHANNEL GATING; KIDNEY; KINETICS; MEMBRANE POTENTIALS; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN STRUCTURE, TERTIARY; SHAB POTASSIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAETHYLAMMONIUM;

EID: 1842786940     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.200308976     Document Type: Article

References (63)

1. + channel. Neuron. 16: 1169-1177.
2. Andalib, P., M.J. Wood, and S.J. Korn. 2002. Control of outer vestibule dynamics and current magnitude in the Kv2.1 potassium channel. J. Gen. Physiol. 120:739-755.
3. Armstrong, C.M., and B. Hille. 1972. The inner quaternary ammonium ion receptor in potassium channels of the Node of Ranvier. J. Gen. Physiol. 59:388-400.
4. Armstrong, C.M., and F. Bezanilla. 1974. Charge movement associated with the opening and closing of the activation gates of the Na channels. J. Gen. Physiol. 63:533-552.
5. Bao, H., A. Hakeem, M. Henteleff, J.G. Starkus, and M.D. Rayner. 1999. Voltage-insensitive gating after charge-neurtalizing mutations in the S4 segment of Shaker channels. J. Gen. Physiol. 113: 139-151.
6. + channel. Science. 271:653-656.
7. Broomand, A., R. Mannikko, H.P. Larsson, and F. Elinder. 2003. Molecular movement of the voltage sensor in a K channel. J. Gen. Physiol. 122:741-748.
8. Cahalan, M.D., K.G. Chandy, T.E. DeCoursey, and S. Gupta. 1985. A voltage-gated potassium channel in human T lymphocytes. J. Physiol. 358:197-237.
9. + channel with fluorescence. Neuron. 19:1127-1140.
10. + channel. Neuron. 32:649-656.
11. + channel correlate with occupancy of the pore. Biophys. J. 61:639-648.
12. Ding, S., and R. Horn. 2003. Effect of S6 tail mutations on charge movement in Shaker potassium channels. Biophys. J. 84:295-305.
13. Elinder, F., P. Arhem, and H.P. Larsson. 2001a. Localization of the extracellular end of the voltage sensor S4 in a potassium channel. Biophys. J. 80:1802-1809.
14. Elinder, F., R. Mannikko, and H.P. Larsson. 2001b. S4 charges move close to residues in the pore domain during activation in a K channel. J. Gen. Physiol. 118:1-10.
15. Flynn, G.E., and W.N. Zagotta. 2001. Conformational changes in S6 coupled to the opening of cyclic nucleotide-gated channels. Neuron. 30:689-698.
16. + channel voltage-sensing domain. Neuron. 40:515-525.
17. + channel. J. Gen. Physiol. 119:521-531.
18. Hodgkin, A.L., and A.F. Huxley. 1952. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 117:500-544.
19. + channels. Evidence for a trap door mechanism of activation gating. J. Gen. Physiol. 109:527-535.
20. + channel can be trapped in the open state by an intersubunit metal bridge. Neuron. 21:617-621.
21. Ikeda, S.R., and S.J. Korn. 1995. Influence of permeating ions on potassium channel block by external tetraethylammonium. J. Physiol. 486:267-272.
22. Immke, D., MJ. Wood, L. Kiss, and S.J. Korn. 1999. Potassium-dependent changes in the conformation of the Kv2.1 potassium channel pore. J. Gen. Physiol. 113:819-836.
23. +-dependent modulation of tetraethylammonium efficacy in Kv2.1 potassium channels. J. Gen. Physiol. 115:509-518.
24. Islas, L.D., and F.J. Sigworth. 1999. Voltage sensitivity and gating charge in Shaker and Shah family potassium currents. J. Gen. Physiol. 114:723-741.
25. + channel. Nature. 423:42-48.
26. Jurman, M.E., L.M. Boland, Y. Liu, and G. Yellen. 1994. Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques. 17:876-881.
27. + at the potassium channel selectivity filter. Biophys. J. 74:1840-1849.
28. Kiss, L., J. LoTurco, and S.J. Korn. 1999. Contribution of the selectivity filter to inactivation in potassium channels. Biophys. J. 76: 253-263.
29. + channel probed by sulfhydryl-specific reagents after cysteine scanning mutagenesis. Biophys. J. 68:900-905.
30. Laine, M., M.-C.A. Lin, J.P.A. Bannister, W.R. Silverman, A.F. Mock, B. Roux, and D.M. Papazian. 2003. Atomic proximity between S4 segment and pore domain in Shaker potassium channels. Neuron. 39:467-481.
31. + channel S4. Neuron. 16:387-397.
32. Ledwell, J.L., and R.W. Aldrich. 1999. Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. J. Gen. Physiol. 113:389-414.
33. Lee, H.C., J.M. Wang, and K.J. Swartz. 2003. Interaction between extracellular hanatoxin and the resting conformation of the voltage-sensor paddle in Kv channels. Neuron. 40:527-536.
34. Levy, D.I., and C. Deutsch. 1996. Recovery from C-type inactivation is modulated by extracellular potassium. Biophys. J. 70:798-805.
35. + channel during gating. Neuron. 16: 859-867.
36. + channel. Neuron. 19: 175-184.
37. + channel. Pflugers Arch. 435:654-661.
38. Lopez-Barneo, J., T. Hoshi, S.H. Heinemann, and R.W. Aldrich. 1993. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors Channels. 1:61-71.
39. + channel's slow inactivation gate. J. Gen. Physiol. 116:623-635.
40. Lu, T., L.W. Wu, J. Xiao, and J. Yang. 2001a. Permeant ion-dependent changes in gating of Kir2.1 inward rectifier potassium channels. J. Gen. Physiol. 118:509-521.
41. + channel with backbone mutations in the selectivity filter. Nat. Neurosci. 4:239-246.
42. + channels. J. Gen. Physiol. 120:663-676.
43. + currents, IK, are encoded by Kv2 α-subunits and regulate tonic firing in mammalian sympathetic neurons. J. Neurosci. 22:10094-10105.
44. Matteson, D.R., and R.P. Swenson, Jr. 1986. External monovalent cations that impede the closing of K channels. J. Gen. Physiol. 87: 795-816.
45. Milligan, C.J., and D. Wray. 2000. Local movement in the S2 region of the voltage-gated potassium channel hKv2.1 studied using cysteine mutagenesis. Biophys. J. 78:1852-1861.
46. Neale, E.J., D.J.S. Elliott, M. Hunter, and A. Sivaprasadarao. 2003. Evidence for intersubunit interactions between S4 and S5 transmembrane segments of the Shaker potassium channel. J. Biol. Chem. 278:29079-29085.
47. + channels. J. Gen. Physiol. 97:641-665.
48. Proks, P., J.F. Antcliff, and F.M. Ashcroft. 2003. The ligand-sensitive gate of a potassium channel lies close to the selectivity filter. EMBO Rep. 4:70-75.
49. +. J. Gen. Physiol. 98:535-554.
50. Schoppa, N.E., and F.J. Sigworth. 1998. Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels. J. Gen. Physiol. 111:313-342.
51. + channel. Neuron. 16: 1159-1167.
52. + channel signature sequence of murine Kir2.1: mutations that affect microscopic gating but not ionic selectivity. J. Physiol. 531:37-50.
53. + channel. Neuron. 19:1319-1327.
54. Sun, Z.-P., M.H. Akabas, E.H. Goulding, A. Karlin, and S.A. Siegelbaum. 1996. Exposure of residues in the cyclic nucleotide-gated channel pore: P region structure function in gating. Neuron. 16: 141-149.
55. +. Nature. 291: 427-429.
56. + channel DRK1. Proc. Natl. Acad. Sci. USA. 90: 4758-4762.
57. + channels. J. Biol. Chem. 277:18994-19000.
58. + channel Kv1.5. Biophys. J. 79:9416-2433.
59. +-dependent potentiation in Kv2.1 potassium channels. Biophys. J. 79:2535-2546.
60. Yang, N., A.L. George, Jr., and R. Horn. 1996. Molecular basis of charge movement in voltage-gated sodium channels. Neuron. 16: 113-122.
61. + channel allows inactivation to be modulated by metal binding. Biophys. J. 66: 1068-1075.
62. Zheng, J., and F.J. Sigworth. 1998. Intermediate conductances during deactivation of heteromultimeric Shaker potassium channels. J. Gen. Physiol. 112:457-474.
63. + channel-Fab complex at 2.0 Å resolution. Nature. 414:43-48.