Exploration of antimicrobial potential in LAB by genomics

Current Opinion in Biotechnology

Volumn 15, Issue 2, 2004, Pages 100-104

  Nes, Ingolf F ^a   Johnsborg, Ola ^a  

^a NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

Author keywords

LAB; Lactic acid bacteria

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BACTERIOCIN; NISIN; REUTERICYCLIN; REUTERIN; SAKACIN A; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIFUNGAL ACTIVITY; BACTERIAL GENE; BACTERIAL GENOME; BIOINFORMATICS; BIOTECHNOLOGY; CLOSTRIDIUM; DRUG POTENCY; DRUG TARGETING; ESCHERICHIA COLI; FOOD PRESERVATION; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC CODE; GENETIC TRANSCRIPTION; LACTIC ACID BACTERIUM; LACTOBACILLUS SAKEI; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIOCINS; FOOD INDUSTRY; FOOD MICROBIOLOGY; FOOD PRESERVATIVES; GENOME, BACTERIAL; GENOMICS; GRAM-POSITIVE BACTERIA; LACTIC ACID; MOLECULAR SEQUENCE DATA;

BACTERIA (MICROORGANISMS); CLOSTRIDIUM; ESCHERICHIA COLI; LACTOBACILLUS; LACTOBACILLUS SAKEI; NEGIBACTERIA; POSIBACTERIA;

EID: 1842664393     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.copbio.2004.02.001     Document Type: Review

References (28)

1. Hechard Y., Sahl H.G. Mode of action of modified and unmodified bacteriocins from Gram-positive bacteria. Biochimie. 84:2002;545-557.
2. Eijsink V.G., Axelsson L., Diep D.B., Havarstein L.S., Holo H., Nes I.F. Production of class II bacteriocins by lactic acid bacteria; an example of biological warfare and communication. Antonie Van Leeuwenhoek. 81:2002;639-654.
3. Diep D.B., Nes I.F. Ribosomally synthesized antibacterial peptides in Gram-positive bacteria. Curr Drug Targets. 3:2002;107-122.
4. Van Den Hooven H.W., Doeland C.C., Van De Kamp M., Konings R.N., Hilbers C.W., Van De Ven F.J. Three-dimensional structure of the lantibiotic nisin in the presence of membrane-mimetic micelles of dodecylphosphocholine and of sodium dodecylsulphate. Eur J Biochem. 235:1996;382-393.
5. Breukink E., Wiedemann I., van Kraaij C., Kuipers O.P., Sahl H.G., de Kruijff B. Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic. Science. 286:1999;2361-2364.
6. Wiedemann I., Breukink E., van Kraaij C., Kuipers O.P., Bierbaum G., de Kruijff B., Sahl H.G. Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity. J Biol Chem. 276:2001;1772-1779 Nisin is the first food-applied lantibiotic that has been shown to bind to a receptor-like molecule (lipid II), commonly referred to as a docking molecule. This paper identifies the structural requirements for the interaction of nisin with its docking molecule, lipid II.
7. Eijsink V.G., Skeie M., Middelhoven P.H., Brurberg M.B., Nes I.F. Comparative studies of class IIa bacteriocins of lactic acid bacteria. Appl Environ Microbiol. 64:1998;3275-3281.
8. Fregeau Gallagher N.L., Sailer M., Niemczura W.P., Nakashima T.T., Stiles M.E., Vederas J.C. Three-dimensional structure of leucocin A in trifluoroethanol and dodecylphosphocholine micelles: spatial location of residues critical for biological activity in type IIa bacteriocins from lactic acid bacteria. Biochemistry. 36:1997;15062-15072.
9. Wang Y., Henz M.E., Gallagher N.L., Chai S., Gibbs A.C., Yan L.Z., Stiles M.E., Wishart D.S., Vederas J.C. Solution structure of carnobacteriocin B2 and implications for structure-activity relationships among type IIa bacteriocins from lactic acid bacteria. Biochemistry. 38:1999;15438-15447.
10. Yan L.Z., Gibbs A.C., Stiles M.E., Wishart D.S., Vederas J.C. Analogues of bacteriocins: antimicrobial specificity and interactions of leucocin A with its enantiomer, carnobacteriocin B2, and truncated derivatives. J Med Chem. 43:2000;4579-4581.
11. Gravesen A., Ramnath M., Rechinger K.B., Andersen N., Jansch L., Hechard Y., Hastings J.W., Knochel S. High-level resistance to class IIa bacteriocins is associated with one general mechanism in Listeria monocytogenes. Microbiology. 148:2002;2361-2369 The bacteriocin resistance mechanism is poorly understood. In this paper, our understanding of the class IIa bacteriocin resistance mechanism is extended, linking the seemingly divergent results previously reported. It shows the importance of the involvement of the mannose-specific phosphoenolpyruvate-dependent phosphotransferase system.
12. Diep D.B., Axelsson L., Grefsli C., Nes I.F. The synthesis of the bacteriocin sakacin A is a temperature-sensitive process regulated by a pheromone peptide through a three-component regulatory system. Microbiology. 146:2000;2155-2160.
13. Sahl H.G., Jack R.W., Bierbaum G. Biosynthesis and biological activities of lantibiotics with unique post-translational modifications. Eur J Biochem. 230:1995;827-853.
14. Håvarstein L.S., Holo H., Nes I.F. The leader peptide of colicin V shares consensus sequences with leader peptides that are common among peptide bacteriocins produced by Gram-positive bacteria. Microbiology. 140:1994;2383-2389.
15. Håvarstein L.S., Diep D.B., Nes I.F. A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export. Mol Microbiol. 16:1995;229-240.
16. Klaenhammer T., Altermann E., Arigoni F., Bolotin A., Breidt F., Broadbent J., Cano R., Chaillou S., Deutscher J., Gasson M.et al. Discovering lactic acid bacteria by genomics. Antonie Van Leeuwenhoek. 82:2002;29-58 An excellent review of genome sequencing projects for bacteria used in food production, with an emphasis on LAB.
17. Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S., DeHoff B.S., Estrem S.T., Fritz L., Fu D.J., Fuller W.et al. Genome of the bacterium Streptococcus pneumoniae strain R6. J Bacteriol. 183:2001;5709-5717 Reports the genome sequence of S. pneumoniae, an LAB that causes disease in humans but is also a comensal bacterium. Gene annotation shows that the genome carries several putative new bacteriocin-encoding genes. This is an important finding, which suggests that many new bacteriocins might be found in our environment.
18. de Saizieu A., Gardes C., Flint N., Wagner C., Kamber M., Mitchell T.J., Keck W., Amrein K.E., Lange R. Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide. J Bacteriol. 182:2000;4696-4703.
19. Reichmann R., Hakenbeck R. Allelic variation in a peptide-inducible two-component system of Streptococcus pneumoniae. FEMS Microbiol Lett. 190:2000;231-236.
20. Ajdic D., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.et al. Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. Proc Natl Acad Sci USA. 99:2002;14434-14439.
21. Talarico T.L., Casas I.A., Chung T.C., Dobrogosz W.J. Production and isolation of reuterin, a growth inhibitor produced by Lactobacillus reuteri. Antimicrob Agents Chemother. 32:1988;1854-1858.
22. Holtzel A., Ganzle M.G., Nicholson G.J., Hammes W.P., Jung G. The first low molecular weight antibiotic from lactic acid bacteria: reutericyclin, a new tetramic acid. Angew Chem Int Ed Engl. 39:2000;2766-2768.
23. Strøm K., Sjøgren J., Broberg A., Schnurer J. Lactobacillus plantarum MiLAB 393 produces the antifungal cyclic dipeptides cyclo(L-Phe-L-Pro) and cyclo(L-Phe-trans-4-OH- L-Pro) and 3-phenyllactic acid. Appl Environ Microbiol. 68:2002;4322-4327.
24. Magnusson J., Strøm K., Roos S., Sjøgren J., Schnurer J. Broad and complex antifungal activity among environmental isolates of lactic acid bacteria. FEMS Microbiol Lett. 219:2003;129-135 More than 1200 isolates of LAB were screened for antifungal activity. Approximately 4% of the isolates showed strong activity against the indicator mould. Several antifungal cyclic dipeptides were identified and several other active fractions were found, suggesting a highly complex nature of the antifungal activity. This study suggests that some antifungal compounds are widely distributed among different species of LAB.
25. Kleerebezem M., Hugenholtz J. Metabolic pathway engineering in lactic acid bacteria. Curr Opin Biotechnol. 14:2003;232-237.
26. Vadyvaloo V., Hastings J.W., van der Merwe M.J., Rautenbach M. Membranes of class IIa bacteriocin-resistant Listeria monocytogenes cells contain increased levels of desaturated and short-acyl-chain phosphatidylglycerols. Appl Environ Microbiol. 68:2002;5223-5230.
27. Crandall A.D., Montville T.J. Nisin resistance in Listeria monocytogenes ATCC 700302 is a complex phenotype. Appl Environ Microbiol. 64:1998;231-237.
28. Integrated Genomics. URL: http://wit.integratedgenomics.com.