Expression and activity of cyclin-dependent kinases and glycogen synthase kinase-3 during NT2 neuronal differentiation

NeuroSignals

Volumn 13, Issue 3, 2004, Pages 134-143

  Gompel, Marie ^a   Soulié, Cathia ^b   Ceballos Picot, Irène ^b   Meijer, Laurent ^a  

^a STATION BIOLOGIQUE   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Alzheimer's disease; Cyclin dependent kinase; Glycogen synthase kinase; GSK 3 ; Kinase inhibitor; Paullones; Purines

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3; PROTEIN P35;

ARTICLE; CELL DIFFERENTIATION; CELL VIABILITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; HUMAN; HUMAN CELL; IN VITRO STUDY; NERVE CELL; NERVE CELL DIFFERENTIATION; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN-DEPENDENT KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOBLOTTING; NEURONS; TERATOCARCINOMA; TIME FACTORS; TRETINOIN;

EID: 1842612056     PISSN: 1424862X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000076567     Document Type: Article

References (33)

1. Cohen P: The origins of protein phosphorylation. Nat Cell Biol 2002;4:E127-130.
2. Paglini G, Caceres A: The role of the Cdk5-p35 kinase in neuronal development. Eur J Biochem 2001;268:1528-1533.
3. Dhavan R, Tsai LH: A decade of CDK5. Nat Rev Mol Cell Biol 2001;2:749-759.
4. Embi N, Rylatt DB, Cohen P: Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur J Biochem 1980;107:519-527.
5. Doble BW, Woodgett JR: GSK-3: Tricks of the trade for a multi-tasking kinase. J Cell Sci 2003;116:1175-1186.
6. Hall AC, Lucas FR, Salinas PC: Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling. Cell 2000;100:525-535.
7. Goold RG, Gordon-Weeks PR: Microtubule-associated protein 1B phosphorylation by glycogen synthase kinase 3beta is induced during PC12 cell differentiation. J Cell Sci 2001;114:4273-4284.
8. Mukai F, Ishiguro K, Sano Y, Fujita SC: Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3beta. J Neurochem 2002;81(5):1073-1083.
9. Pleasure SJ, Lee VM: NTera 2 cells: A human cell line which displays characteristics expected of a human committed neuronal progenitor cell. J Neurosci Res 1993;35:585-602.
10. Pleasure SJ, Page C, Lee VM: Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. J Neurosci 1992;12:1802-1815.
11. Sanchez C, Diaz-Nido J, Avila J: Phosphorylation of microtubule- associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function. Prog Neurobiol 2000;61:133-168.
12. Tsai LH, Takahashi T, Caviness VS, Harlow E: Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development 1993;119:1029-1040.
13. Azzi L, Meijer L, Ostvold A, Lew J, Wang J: Purification of a 15-kDa cdk4- and cdk5-binding protein. J Biol Chem 1994;269:13279-13288.
14. Primot A, Baratte B, Gompel M, Borgne A, Liabeuf S, Romette JL, et al: Purification of GSK-3 by affinity chromatography on immobilized axin. Protein Expr Purif 2000;20:394-404.
15. Lau KF, Miller CC, Anderton BH, Shaw PC: Expression analysis of glycogen synthase kinase-3 in human tissues. J Pept Res 1999;54(1):85-91.
16. Stoothoff WH, Bailey CD, Mi K, Lin SC, Johnson GV: Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta. J Neurochem 2002;83:904-913.
17. Tsai LH, Delalle I, Caviness VS, Chae T, Harlow E: p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 1994;371:419-423.
18. Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, et al: p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci 2001;21:6758-6771.
19. Nikolic M, Dudek H, Kwon YT, Ramos YF, Tsai LH: The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Genes Dev 1996;10:816-825.
20. Fu WY, Wang JH, Ip NY: Expression of Cdk5 and its activators in NT2 cells during neuronal differentiation. J Neurochem 2002;81:646-654.
21. Cheung WM, Fu WY, Hui WS, Ip NY: Production of human CNS neurons from embryonal carcinoma cells using a cell aggregation method. Biotechniques 1999;26:946-948, 950-952, 954.
22. Takahashi M, Tomizawa K, Kato R, Sato K, Uchida T, Fujita SC, et al: Localization and developmental changes of tau protein kinase I/glycogen synthase kinase-3 beta in rat brain. J Neurochem 1994;63:245-255.
23. Leroy K, Brion JP: Developmental expression and localization of glycogen synthase kinase-3beta in rat brain. J Chem Neuroanat 1999;16:279-293.
24. Marcus EA, Kintner C, Harris W: The role of GSK3beta in regulating neuronal differentiation in Xenopus laevis. Mol Cell Neurosci 1998;12:269-280.
25. Takahashi M, Yasutake K, Tomizawa K: Lithium inhibits neurite growth and tau protein kinase I/glycogen synthase kinase-3beta-dependent phosphorylation of juvenile tau in cultured hippocampal neurons. J Neurochem 1999;73:2073-2083.
26. Schaffer B, Wiedau-Pazos M, Geschwind DH: Gene structure and alternative splicing of glycogen synthase kinase 3 beta (GSK-3beta) in neural and non-neural tissues. Gene 2003;302:73-81.
27. Knockaert M, Wieking K, Schmitt S, Leost M, Grant KM, Mottram JC, et al: Intracellular Targets of Paullones: Identification following affinity purification on immobilized inhibitor. J Biol Chem 2002;277:25493-25501.
28. Ding S, Wu TYH, Brinker A, Peters EC, Hur W, Gray NS, Schultz PG: Synthetic small molecules that control stem cell fate. PNAS 2003:0732087100.
29. Mosmann T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63.
30. Chang YT, Gray NS, Rosania GR, Sutherlin DP, Kwon S, Norman TC, et al: Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chem Biol 1999;6:361-375.
31. Leost M, Schultz C, Link A, Wu YZ, Biernat J, Mandelkow EM, et al: Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase5/p25. Eur J Biochem 2000;267:5983-5994.
32. Meijer L, Borgne A, Mulner O, Chong JP, Blow JJ, Inagaki N, et al: Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem 1997;243:527-536.
33. Schultz C, Link A, Leost M, Zaharevitz DW, Gussio R, Sausville EA, et al: Paullones, a series of cyclin-dependent kinase inhibitors: Synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. J Med Chem 1999;42:2909-2919.