Production of human CNS neurons from embryonal carcinoma cells using a cell aggregation method

BioTechniques

Volumn 26, Issue 5, 1999, Pages 946-954

  Cheung, William M W ^a   Fu, Wing Y ^a   Hui, Wing S ^a   Ip, Nancy Y ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID;

ARTICLE; CELL AGGREGATION; CELL DIFFERENTIATION; EMBRYONAL CARCINOMA; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NERVE CELL; PROMOTER REGION; QUANTITATIVE DIAGNOSIS;

EID: 0032936126     PISSN: 07366205     EISSN: None     Source Type: Journal    
DOI: 10.2144/99265rr04     Document Type: Article

References (20)

1. Andrews, P.W. 1984. Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev. Biol. 705:285-293.
2. Andrews, P.W., I. Damjanov, D. Simon, G.S. Banting, C. Carlin, N.C. Dracopoli and J. Fogh. 1984. Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Lab. Invest. 50:147-162.
3. Bain, G., D. Kitchens, M. Yao, J.E. Huettner and D.I. Gottlieb. 1995. Embryonic stem cells express neuronal properties in vitro. Dev. Biol. 168:342-357.
4. Chambon, P. 1996. A decade of molecular biology of retinoic acid receptors. FASEB J. 70:940-954.
5. Cheung W.M.W., A.H. Chu and N.Y. Ip. 1997. Identification of candidate genes induced by retinoic acid in embryonal carcinoma cells. J. Neurochem. 68:1882-1888.
6. Cheung, W.M.W., A.H. Chu, M.-F. Leung and N.Y. Ip. 1996. Induction of trk receptors by retinoic acid in a human embryonal carcinoma cell line. Neuroreport 7:1204-1208.
7. Chyung, A.S.C., B.D. Greenberg, D.G. Cook, R.W. Doms and V.M.-Y. Lee. 1997. Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2/N cells. J. Cell Biol. 755:671-680.
8. De Luca, L.M. 1991. Retinoids and their receptors in differentiation, embryogenesis, and neoplasia. FASEB J. 5:2924-2933.
9. Hoffer, B. and L. Olson. 1997. Treatment strategies for neurodegenerative diseases based on trophic factors and cell transplantation techniques. J. Neural Transm. Suppl. 49:1-10.
10. Iacovitti, L. and N.D. Stull. 1997. Expression of tyrosine hydroxylase in newly differentiated neurons from a human cell line (hNT). Neuroreport 8:1471-1474.
11. Jones-Villeneuve, E.M., M.W. McBurney, K.A. Rogers and V.I. Kalnins. 1982. Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells. J. Cell Biol. 94:253-262.
12. Jones-Villeneuve, E.M., M.A. Rudnicki, J.F. Harris and M.W. McBurney. 1983. Retinoic acid-induced neural differentiation of embryonal carcinoma cells. Mol. Cell Biol. 5:2271-2279.
13. Larue, L., C. Antos, S. Butz, O. Huber, V. Delmas, M. Dominis and R. Kemler. 1996. A role for cadherins in tissue formation. Development 722:3185-3194.
14. Llanes, C., R.G. Collman, R. Hrin and D.L. Kolson. 1995. Acetylcholinesterase expression in NTera2 human neuronal cells: a model for developmental expression in the nervous system. J. Neurosci. Res. 42:791-802.
15. Marazzi, G., Y. Wang and D. Sassoon. 1997. Msx2 is a transcriptional regulator in the BMP-mediated programmed cell death pathway. Dev. Biol. 186:127-138.
16. Pleasure, S J. and V.M.-V. Lee. 1993. NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell. J. Neurosci. Res. 55:585-602.
17. Pleasure, SJ., C. Page and V.M.-Y. Lee. 1992. Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. J. Neurosci. 72:1802-1815.
18. Smith, S.C., K.R. Reuhl, J. Craig and M.W. McBurney. 1987. The role of aggregation in embryonal carcinoma cell differentiation. J. Cell. Physiol. 131:14-84.
19. Toth, M., T. Shenk and E. Madarasz. 1995. Differentiation is induced in three-dimensional cultures of brain cells immortalized by the LAP mammalian regulatory system. J. Neurosci. Res. 47:764-774.
20. Trojanowski, J.Q., S.R. Kleppner, R.S. Hartley, M. Miyazono, N.W. Fräser, S. Kesari and V.M.-Y. Lee. 1997. Transfectable and transplantable postmitotic human neurons: a potential "platform" for gene therapy of nervous system diseases. Exp. Neurol. 744:92-97.