Congenital heart block associated with maternal anti SSA/SSB antibodies: A report of four cases;Bloc auriculoventriculaire congénital associé à des autoanticorps anti-SSA/SSB maternels: À propos de quatre observations

Pathologie Biologie

Volumn 52, Issue 3, 2004, Pages 138-147

  Ayed, K ^a   Gorgi, Y ^a   Sfar, I ^a   Khrouf, M ^a  

^a CHARLES NICOLLE HOSPITAL   (Tunisia)

Author keywords

Anti SSA antibodies; Anti SSB; Anti SSB antibodies; Anticorps anti SSA; Auto anticorps maternels; Bloc auriculoventriculaire cong nital; Congenital heart block; Maternal autoantibodies

Indexed keywords

LA ANTIBODY; MATERNAL ANTIBODY; RO ANTIBODY; UNCLASSIFIED DRUG;

ACCURACY; ADULT; ARTICLE; ARTIFICIAL HEART PACEMAKER; BRADYCARDIA; CASE REPORT; CHILDBIRTH; CLINICAL FEATURE; CONGENITAL HEART BLOCK; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; FETUS; FETUS DEATH; GESTATIONAL AGE; HEART MUSCLE CONDUCTION DISTURBANCE; HUMAN; IMMUNE SYSTEM; LABORATORY TEST; MATERNAL SERUM; NEWBORN; NEWBORN SURGERY; PATIENT; PREGNANCY; PREGNANCY COMPLICATION; SYMPTOM; TREATMENT INDICATION;

ADULT; ANTIBODIES, ANTINUCLEAR; AUTOANTIGENS; AUTOIMMUNE DISEASES; BRADYCARDIA; CARDIAC PACING, ARTIFICIAL; FEMALE; FETAL DEATH; FETAL DISEASES; FETAL HEART; HEART BLOCK; HUMANS; IMMUNITY, MATERNALLY-ACQUIRED; INFANT, NEWBORN; ISOANTIBODIES; MALE; PREGNANCY; PREGNANCY COMPLICATIONS; RIBONUCLEOPROTEINS; RNA, SMALL CYTOPLASMIC;

EID: 1842611752     PISSN: 03698114     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.patbio.2003.06.002     Document Type: Article

References (86)

1. Hochberg M.D., Boyd R.E., Ahearm J.M., et al. Systemic lupus erythematosus: a review of clinico-laboratory fractures and immunogenetic markers in 150 patients with emphasis on demographic subsets. Medicine. 64:1985;285-290.
2. Lockshin M.D., Bonfa E., Elkon K., et al. Neonatal lupus risk to new borns of mothers with systemic lupus erythemotosus. Arthritis Rheum. 31:1988;697.
3. Taylor P.V., Taylor K.F., Norman A., Griffiths S., Scott J.S. Prevalence of maternal Ro (SSA) and SSB(La) autoantibodies in relation to complete heart block. Br. J. Rheumatol. 27:1988;128-135.
4. 5th (ed) Wallace D., Hahn B.H. Dubois Lupus Erythematosus. 1996;Lea and Febiger, Philadelphia.
5. Borrego L., Ridriguez J., Soler E., Jimenez A., Hernandez B. Neonatal lupus erythematosus related to maternal leukocytoclastic vasculitis. Pediatr Dermatol. 14:(3):1997 May-Jun;221.
6. Boutjdir M., Chen L., Zhang Z.H., Tseng C.E., El-Sherif N., Buyon J.P. Serum and immunoglobulin G from the mother of a child with congenital heart Recherche: Congenital heart block SSA/Ro. Circ Res. 80:1997;354-362.
7. Mayet W.J., Hermann E., Bachmann M., Poralla T., Meyer Zun Buschenfelde K.H. Neonatal lupus erythematosus. Z. Rheumatol. 48:(2):1989. Mar-Apr;57-62. Germa.
8. Meyer O., Wallach D., Debois J.C. Les Ac antinucléaires anti SSA sont ils responsables des connectivites neonatales Nov. Pres Med. 11:1982;2717.
9. Watson R.M., Braunstein B.L., Watson A.J., et al. Foetal wastage in women with anti Ro (SSA) antibody. J. Rheumatol. 13:1986;90-94.
10. Hung C.L., Lin C.H., Mu S.C., Sung T.C. Hydrops fetalis with complete heart block secondary to congenital lupus: report of one case. Acta paediatr Taiwan. 40:(4):1999 Jul-Aug;265-267.
11. Eftekhari P., Salle L., Lezoualc'h F., Mialet J., Gasteineau M., Briand J.P., Isenberg D.A., Fournie G.J., Argibay J., Fischmeister R., Muller S., Hoebeke J. Anti-SSA/Ro52 autoantibodies blocking the cardiac 5-HT4 serotoninergic receptor could explain neonatal lupus congenital heart block. Eur J Immunol. 30:(10):2000. Oct;2782-2790.
12. Mc Credie M., Alermajer J., Sholler G., et al. A case control study of congenital heart block: association with maternal antibodies to Ro (SSA) and La (SSB). J. Rheumatol. 29:1990;10.
13. Scott J.S., Maddison P.J., Taylor P.V. Connectivite tissue disease antibodies to ribonucleoprotéine and congenital heart block. N. Engl J. Med. 309:1983;209. et coll.
14. Vetter V.J., Rashkind W.J. congenital complete heart block and connective tissue disease. N. Engl. J. Med. 309:1983;235.
15. Weston W.L., Harmon C., Peells. A serological marker for neonatal lupus erythematosus. Br. J. Dermatol. 107:1982;377. et Col.
16. Logar D., Kveder T., Rozman B., Dobovisek J. Possible association between anti-Ro antibodies and myocaditis or cardiac conduction defects in adults with systemic lupus erthematosus. Ann. Rheum Dis. 49:(8):1990 Aug;627-629.
17. Batisse A., Belloy C., Fermont L., Piechaud J.F., Kachaner J. Allongement de l'espace QT avec BAV fonctionnel chez le nouveau né et le jeune nourisson. Arch. Fr. Pediat. 1981;36-657.
18. Herreman G.A. "anti-Ro (SSA) anti-La (SSB) antibodies and complete congenital heart block" Ann Med Interne (Paris). 148:(8):1997;582. A propos of the article by Y. Filkelstein et al.
19. Karpawich P.P., Gillette P.C., Garson A., et al. Congenital complet atrioventricular predictors of need for pacemaker insertion. Am. J. Cardiol. 48:1981;1098-2003.
20. De Parseval N., Forrest G., Venables P.J., Heidmann T. ERV-3 envelope expression and congenital heart block: what does a physiological knockout teach us. Auto-immunity. 30:(2):1999;81-83.
21. Tucker L.B., Meon S., Sutaller J.G., Isenberg D.A. Adult and childhood onset, clinical features, serology and out come. Britsh Journal of Rheumatology. 34:1997;866-872.
22. Black Shear P.J., Rotner H.E., Kriancinas K.A.M. Reactive hypoglycemia and insulin auto ab in drug induced lupus erythematosus. Ann. Intern. Med. 99:1983;181-182. et coll.
23. Boutjdir M. Molecular and ionic basis of congenital complete heart block. Trends cardiovasc Med. 10:(3):2000 Apr;114-122.
24. Deng J.S., Bair L.W., Shen - Schwarz S., et al. Localization of Ro (SSA) antigen in the cardiac conduction system. Arthritis Rheum. 30:1987;1232-1236.
25. Xiao G.Q., Qu Y., Hu K., Boutjdir M. Down-regulation of L-type calcium channel in pups born to 52 KDa SSA/Ro immunized rabbits. Faseb J. 15:(9):2001 Jul;1539-1545.
26. Xiao G.Q., Hu K., Boutjdir M. Direct inhibition of expressed cardiac l- and t - type calcium channels by IgG from mothers whose children have congenital heart block. Circulation. 103:(11):2001 Mars 20;1599-1604.
27. Tekeda K., Yu Z., Nishikawa T., Tanaka M., Hosoda S., Ferrans V.J., Kasajima T. A poptosis and DNA fragmentation in the bulbus cordis of the developing rat heart. J. Mol. Cell. Cardiol. 28:1996;209.
28. Ucker D.S. Death by suicide: one way to go in mammalian cellular developpment? Niw Biol. 3:1991;103-106.
29. Yalaoui S., Gorgi Y., Ayed K. Evaluation d'une technique d'immunoblot pour la detection des anticorps anti SSA et des anticorps anti SSB. Pathol Biologie. 49:2001;265-269.
30. Buyon J. Szer:I Passively acquired autoimmunity and the maternal foetal dyard in systemic lupus erythematosus spinger. Semi Immunopathol. 3:1986;283.
31. Neiman A.R., Lee L.A., Weston W.L., Buyon J.P. Cutaneous manifestations of neonatal lupus without heart block: characteristics of mothers and children enrolled in national registry. J. Pediatr. 137:(5):2000 Nov;674-680.
32. Ghayad E., Haddad F., Tohme A., Salame E. Neonatal lupus erythematosis and atrial-ventricular block. A case report and review of the literature. J Med Liban. 46:(1):1998;36-39.
33. Litsey S.E., Noonan J.A., O'Connor W.N., et al. Maternal connectivite tissue disease and congenital heart block. Demonstration of immunoglobulin in cardiac tissue. N. Engl. J. Med. 312:1985;98-102.
34. Goldstein R., Arnett F.C. The genetic of rheumatic disease in man. Rheum. Dis. Clin. North Am. 13:1987;487.
35. Sieper J., Kingsley G. Recent advances in the pathologenesis of reactive arthritis. Immunology today. 17:1996;160.
36. Buyon J.P. The effects of pregnancy on autoimmune diseases. J leukoc Bio. 63:(3):1998 Mar;281-287.
37. Taylor P.V. Autoimmunity and pregnancy. Bailleres clinical immunology and allergy. 2:1988;665-696.
38. Meng C., Lockshin M. Pregnancy in lupus. Curr Opin Rheumatol. 11:(5): 1999 Sep;348-351.
39. Press J., Uzied Y., Laxer R.M., Ley L., Hamilton R.M., Silverman E.D. Long-term outcome of mothers of children with complete congenital heart block. Am J Med. 100:(3):1996 Mar;328-332.
40. Buyon J.P., Waltuck J., Caldwell K., Crawford B., Slade S.G., Copel J., Chan E.K. Relationship between maternal an neonatal levels of antibodies to 48 kDa SSB (La), 52 kDa SSA(Ro), and 60 kDa SSA(Ro) in pregnancies complicated by congenital heart block. J Rheumatol. 21:(10):1994. Oct;1943-1950.
41. Lumpkin L.R., Hall J., Hogan J.D. Neonatal lupus erythematosus a report of three cases associated with anti Ro/SSA antibodiesArch. Dermatol. 121:1985;377. et Coll.
42. Lee LA:Maternal autoantibodies and pregnancy -II: the neonatal lupus syndrome.
43. Hubscher O., Carrilo D., Reichlin M. Congenital heart block and subsequent connective tissue disorder in adolescence lupus. 6:(3):1997;283-284.
44. Ben Chetrit E., Chan E.K.L., Sullivan F.K. A 52KD protein is a novel component of the SSA/Ro antigenic particle. J. Exp Med. 167:1988;1500-1564. et coll.
45. Deutsher S.L., Harley J.B., Keene J.D. Molecular analysis of 60 KDa human Ro ribonucleoprotein. Proc. Nat. Acad. Sci. USA. 85:1988;9479.
46. Lerner M.R., Boyle J.A., Hardin J.A., Steitz J.A. Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus. Scence. 211:1981;400-402.
47. Wang D. Buyon JP, Zhu W, Chan E K.L: Defining a novel 75KDa phosphoprotein associated with SSA/Ro and identification of distinct human autoantibodies. J. Clin. Investing 199 : 104 : 1265-1275
48. Chan E.K., Didonato F., Hamel J.C., Tseng C.E., Buyon J.P. 52 KDa SSA/Ro : genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigens expressed in fetal and adult heart. J. Exp. Med. 182:1995;983.
49. Bovie G., Lopez-longo F.J., Lapointe S., Menar H.A. sera from patients with autoimmune disease recognize conformational determinants on the 60 KD Ro/SSA protein. Arthritis Rheum. 34:1991;722-730.
50. Gottlieb E., Steitz J.A. Function of the mammalian La protein : evidence for its action in transcription termination by RNA polymerase III. EMBO. 8:1989;851.
51. Buyon J.P., Tseng C.E., Didonato F., Rashbaum W., Horris A., Chan E.K.L. Cardiac expression of 52, an alternative transcript of the congenital heart block associated 52 KDa SSa/Ro autoantigen, is maxima during fetal developpment arthritis. Rheum. 40:1997;655-661.
52. Le V.M. Pathogenesis of congenital atrio-ventricular block. Prog Cardiovasc Dis. 15:1972;145-149.
53. Reichlin M., Brucato A., Frank B., Maddison P.J., Mc Cubbin V.R., Wolfson -Reichlin M., Lee L.A. Concentration of autoantibodies to native 60-KDa Ro/SSA and denatured 52 KDa Ro/SSA in eluates from the heart of a child who died with congenital complete heart block. Arthritis Rheum. 37:1994;1698-1703.
54. Salmonsson S., Dorner T., Theander E., Bremme K., Larsson P., Wahren - Herlenius M. A serologic marker for fetal risk of congenital heart block. Arthritis Rheum. 46:(5):2002 May;1233-1241.
55. Maddison P.J., Lee L., Reichlin M., Sinclair A., Wasson C., Shemmer G., Reichlin M. Anti-p57 : a novel association with neonatal lupus. Clin Exp Immunol. 99:(1):1995;42-48.
56. Alexander E., Buyon J.P., Provost T., Guarnieri. anti Ro/ SSA antibodies in the pathophysiology of congenital heart blokc in neonatal lupus syndrome on experimental model : in vitro electrophysiologic and immunocytochemical studies. Arthritis Rheum. 35:1992;176.
57. Garcia S., Nascimento H.M., Boufa E., Levy R., Oliviera S.F., Javares A.V., a campos de carvallio. cellular mecanism of the conduction abnormalities induced by serum from anti Ro/SSA positive patients in rabbit hearts. J. Clin invest. 93:1994;718.
58. Qu Y., Xiao G.Q., Chen L., Boutjdir M. Autoantibodies from mothers of children with congenital heart block downregulate cardiac L-type Ca channels. J Mol Cell Cardiol. 33:(6):2001 Jun;1153-1163.
59. Boutjdir M., Chen L., Zhang Z.H., Tseng C.E., Didonato F., Rashbaum W., Morris A., l-Sherif N., Buyon J.P. Arrhythmogenicity of IgG and anti 52-KD SSA/Ro affinity-purified antibodies from mothers of children with congenital heart block. Circ Res. 80:(3):1997 Mar;354-362.
60. Hanson L.A., Hahn - Zoric M., Dahlgren U., Tolemo E. Anti-idiotypic antibodies from the mother may influence the immune reponse of the foetus and new-born. Acta Paediatrica Japonica. 36:1994;123-127.
61. Tseng C.E., Miranda E., Di Donato F., Boutjdir M., Rashbaum W., Chan E.K., Buyon J.P. mRNA and protein expression of SSA/Ro and SSB/La in human fetal cardiac myocytes cultured using a novel application of the Langendorff procedure. Pediatr Res. 45:(2):1999 Feb;260-269.
62. 2+ currents in cardiac ventricular myocytes. Circ.Res. 79:1996;184-193.
63. Mahony L. 5th ed Emmanouilides G.C., Riemschneider T.A., Allen H.D., Gutgepel. Moss and Adams heart disease in infants children and adolescents, including the fetus and yong adults. Volume 1:1995;17-28 Wiliams and Wilkins, Baltimore.
64. Josephson I.R., Sperelakis N. Sperelakis N., Banks R.O. physiology. 1993;251-269 Little, Brown x Co, Boston.
65. Tseng C.E., Buyon J.P. Neonatal lupus syndromes. Rheum Dis Clin North Am. 23:(1):1997 Feb;31-54.
66. Casciola - Rosen L.A., Anhalt G., Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med. 179:1994;1317. 1322.
67. Herreman G., Ferme I., Morel S., et al. Mort foetal par myocardite et BAV congenital isolé Presse Med. 12:1985;1109.
68. Pexeider T. Cell death in the morphogenesis and teratogenesis of the heart. Adv. Anat. Embryol. Cell Bio. 51:1975;1-5.
69. Lee L.A. Neonatal lupus erythematosus. J. Invest Dermatol. 100:(1):1993 Jan;9S-13S.
70. Taylor P.V., Scott J.S., Gerlis L.M., et al. Maternal antibodies against fetal cardiac antigens in congenital complete heart block. N. Engl. J. Med. 315:1986;667-670.
71. Horsfall A.C., Venables J.W., Taylor P.V., Maini R.N. Ro and La antigens and maternal autoantibody idiotype on the surface of myocardial fibres in congenital heart block. J. Auto Immun. 4:1991;165.
72. Askanase A.D., Friedman D.M., Copel J., Dische M.R., Dubin A., Starc T.J., Katholi M.C., Buyon J.P. Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies. Lupus. 11:(3):2002;145-151.
73. Buyon J.P., Hiebert R., Copel J., Friedman D., Katholi M., Lee L.A., Provost T.T., Reichlin M., Rider L., Rupel A., Saleeb S., Weston W.L., Skovron M.L. Autoimmune -associated congenital heart block : demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry. J. Am Coll Cardiol. 31:(7):1998 Jun;1658-1666.
74. Fadok V.A., Bratton D.L., Konowal A., Freed P.W., Westcott J.Y., Henson P.M. Inhibition of the production of inflammatory cytokines such as tumor necrosis factor alpha. J. Clin. Inv. 101:1998;890-898.
75. Miranda-carus M.E., Askanase A.D., Clancy R.M., Di Donato F., Chou T.M., Libera M.R., Chan E.K., Buyon J.P. Anti-SSA/Ro and anti-SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of TNF-alpha by macrophages. J. Immunol. 165:(9):2000 Nov. 1;5345-5351.
76. Manfredi A.A., Rovere P., Galati G., Heltai S., Bozzolo E., Soldini L., Davoust J., Balestrieri G., Tincani A., Sabbadini M.G. Apoptotic cell clearance in systemic lupus erythematosus I opsonization by antiphospholipid antibodies arthritis. Rheum. 41:1998;205-214.
77. Clancy R.M., Askanase A.D., Kapur R.P., Chiopelas E., Azar N., Miranda-Carus M.E., Buyon J.P. Transdifferentiation of cardiac fibroblasts, a fetal factor in anti-SSA/Ro-SSB/La antibody-mediated congenital heart block. J Immunol. 169:(4):2002 Aug 15;2156-2163.
78. Kalush F., Rimon E., Keller A., Mozes E. Neonatal lupus erythematosus with cardiac involvement in offspring of mothers with experimental systemic lupus erythematosus. J. Clin. Immunol. 14:1994;314-322.
79. Mazel J.A., El-Sherif N., Byon J., Boutjdir M. Electrocardiographic abnormalities in a murine model injected with IgG from mothers of children with congenital heart block. Circulation. 99:(14):1999 Apr 13;1914-1918.
80. Miranda-Carus M.E., Boutjdir M., Tsenq C.E., Didonato F., Chan E.K., Buyon J.P. induction of antibodies reactive with SSA/Ro-SSB/La and development of congenital heart block in a murine model. J. Immunol. 161:(11):1998 Dec 1;5886-5892.
81. Cune M.C.C.M., Mantakas M.E., Tingelsad J.B., Ruddy S. Congenital heart block in new borns of mothers with connective tissue disease. Circulation. 56:1977;82-86.
82. Ramsey Goldman R., Hom D., Deng J.S., et al. Anti SSA antibodies and foetal out come in maternal systemic lupus erythematosus. Arthritis Rheum. 29:1986;1269.
83. Simmons.O-Brien E., Chen S., Watson R., Anton C., Petri M., Hochberg M., Stevens M.B., Provast T.T. One hundred anti-Ro (SSA) antibody positive patients : a 10 - year follow - up. Medecine. 74:1995;109-130.
84. Provost T.T., Watson R., Gammon W.R., et al. The neonatal lupus syndrome associated with U1-RNP (nRNP) antibodies. N. Engl. J. Med. 316:1987;1135-1140.
85. Shinohara K., Miyagawa S., Fujita T., Aono T., Kidoguchi K. Neonatal lupus erythematosus : results of maternal corticosteroid therapy. Obsted gynecol. 93:(6):1999 Jun;952-957.
86. Buyon J.P., Roubey R., Swersky S.H., Pompeo L., Parke A., Baxi L., Winchester R. Complete congenital heart block :risk of occurrence and therapeutic approach to prevention. JRheumatol. 15:(7):1988 jul;1104-1108.