Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies

Lupus

Volumn 11, Issue 3, 2002, Pages 145-151

  Askanase, A D ^a   Friedman, D M ^b   Copel, J ^c   Dische, M R ^d   Dubin, A ^e   Starc, T J ^d   Katholi, M C ^a   Buyon, J P ^a  

^a NYU HOSPITAL FOR JOINT DISEASES   (United States)

^b ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d University College of Physicians and Surgeons ^*  (United States)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Conduction abnormalities; Congenital heart block; Neonatal lupus syndromes; SSA Ro; SSB La

Indexed keywords

DEXAMETHASONE; LA ANTIBODY; MATERNAL ANTIBODY; RO ANTIBODY; RO SSB ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; CHILD; CLINICAL FEATURE; CONGENITAL HEART BLOCK; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE COURSE; ELECTROCARDIOGRAM; HEART ATRIOVENTRICULAR NODE; HEART CONDUCTION; HUMAN; LUPUS ERYTHEMATOSUS; MAJOR CLINICAL STUDY; PR INTERVAL; PRIORITY JOURNAL; SINUS BRADYCARDIA; SINUS NODE; SINUS RHYTHM; TREATMENT INDICATION;

ANTIBODIES, ANTINUCLEAR; AUTOANTIGENS; AUTOIMMUNE DISEASES; CHILD, PRESCHOOL; ELECTROCARDIOGRAPHY; FEMALE; FIBROSIS; HEART BLOCK; HEART DEFECTS, CONGENITAL; HUMANS; INFANT; INFANT, NEWBORN; MALE; MYOCARDIUM; PREGNANCY; RIBONUCLEOPROTEINS; RNA, SMALL CYTOPLASMIC;

EID: 0036219737     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1191/0961203302lu173oa     Document Type: Article

References (24)

1. Maternal autoantibodies and pregnancy-II: The neonatal lupus syndrome
2. Anti-SS-A antibodies and fetal outcome in maternal systemic lupus erythematosus
3. Neonatal risk to newborns of mothers with systemic lupus erythematosus
4. Congenital heart block risk to newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis. A prospective study of 100 women
5. Neonatal lupus syndrome
6. Isolation and characterization of a cDNA clone encoding the 60-kDa component of the human SS-A/Ro ribonucleoprotein autoantigen
7. Molecular analysis of the 60 kDa human Ro ribonucleoprotein
8. Molecular definition and sequence motifs of the 52-kDa component of human SS-A/Ro autoantigen
9. Protein heterogeneity in the human Ro/SSA ribonucleoproteins
10. Genomic structure and amino acid sequence domains of the human La autoantigen
11. Accessibility of SSA/Ro and SSB/La antigens to maternal autoantibodies in apoptotic human fetal cardiac myocytes
12. Anti-SSA/Ro and anti-SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of tumor necrosis factor α by macrophages
13. Cellular mechanism of the conduction abnormalities induced by serum from anti-Ro/SSA-positive patients in rabbit hearts
14. Arrhythmogenicity of IgG and anti-52 kDa SSA/Ro affinity purified antibodies from mothers of children with congenital heart block
15. Direct inhibition of expressed cardiac L- and T-type calcium channels by IgG from mothers whose children have congenital heart block
16. Autoantibodies from mothers of children with congenital heart block downregulate cardiac L-type calcium channels
17. Induction of antibodies reactive with SSA/Ro-SSB/La and development of congenital heart block in a murine model
18. Autoimmune-associated congenital heart block: Mortality, morbidity, and recurrence rates obtained from a national neonatal lupus registry
19. Comparison of treatment with fluorinated glucocorticoids to natural history of autoantibody-associated congenital heart block: Retrospective review of the research registry for neonatal lupus
20. The fetal PR interval: Pulsed Doppler echocardiographic assessment
21. Postnatal progression from second- to third-degree heart block in neonatal lupus syndrome
22. The role of anfi-SSA/Ro-SSB/La autoantibodies in neonatal lupus
23. Anatomy of congenital complete heart block and relation to maternal anti-Ro antibodies
24. Electrocardiographic abnormalities in a murine model injected with IgG from mothers of children with congenital heart block