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Volumn 19, Issue 2, 2004, Pages 575-583

Circulating nucleic acids in plasma and serum (CNAPS) and its relation to stem cells and cancer metastasis: State of the issue

Author keywords

Cancer; Circulating nucleic acids; Metastasis; Stem cells

Indexed keywords

DNA; NUCLEIC ACID; RNA; TELOMERASE; TUMOR MARKER;

EID: 1842611093     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (69)

References (85)
  • 1
    • 0016764251 scopus 로고
    • Spontaneous release of DNA by human blood lymphocytes as shown in an in vitro system
    • Anker P., Stroun M. and Maurice P.A. (1975). Spontaneous release of DNA by human blood lymphocytes as shown in an in vitro system. Cancer Res. 35, 2375-2382.
    • (1975) Cancer Res. , vol.35 , pp. 2375-2382
    • Anker, P.1    Stroun, M.2    Maurice, P.A.3
  • 3
    • 0002832039 scopus 로고    scopus 로고
    • Detection of circulating tumor DNA in the blood (plasma/serum) of cancer patients
    • Anker P., Mulcahy H., Chen X.Q. and Stroun M. (1999). Detection of circulating tumor DNA in the blood (plasma/serum) of cancer patients. Cancer Metastasis Rev. 18, 65-73.
    • (1999) Cancer Metastasis Rev. , vol.18 , pp. 65-73
    • Anker, P.1    Mulcahy, H.2    Chen, X.Q.3    Stroun, M.4
  • 6
    • 0037158692 scopus 로고    scopus 로고
    • Metastatic genes: A progression puzzle
    • Bernards R. and Weinberg R.A.(2002). Metastatic genes: A progression puzzle. Nature 418, 823.
    • (2002) Nature , vol.418 , pp. 823
    • Bernards, R.1    Weinberg, R.A.2
  • 7
    • 0024464266 scopus 로고
    • Biochemical and NMR studies on structure and release conditions of RNA-containing vesicles shed by human colon adenocarcinoma cells
    • Ceccarini M., Guidoni L., Luciani A.M., Mariutti G., Rosi A. and Viti V. (1989). Biochemical and NMR studies on structure and release conditions of RNA-containing vesicles shed by human colon adenocarcinoma cells. Int. J. Cancer 44, 714-721.
    • (1989) Int. J. Cancer , vol.44 , pp. 714-721
    • Ceccarini, M.1    Guidoni, L.2    Luciani, A.M.3    Mariutti, G.4    Rosi, A.5    Viti, V.6
  • 8
    • 0036062060 scopus 로고    scopus 로고
    • Circulating nucleic acids as a tumor marker
    • Chan K.C.A. and Lo Y.M.D. (2002). Circulating nucleic acids as a tumor marker. Histol. Histopathol. 17, 937-943.
    • (2002) Histol. Histopathol. , vol.17 , pp. 937-943
    • Chan, K.C.A.1    Lo, Y.M.D.2
  • 9
    • 0037351819 scopus 로고    scopus 로고
    • Cell-free nucleic acids in plasma, serum and urine: A new tool in molecular diagnosis
    • Chan A.K.C., Chiu R.W.K. and Lo Y.M.D. (2003). Cell-free nucleic acids in plasma, serum and urine: A new tool in molecular diagnosis. Ann. Clin. Biochem. 40, 122-130.
    • (2003) Ann. Clin. Biochem. , vol.40 , pp. 122-130
    • Chan, A.K.C.1    Chiu, R.W.K.2    Lo, Y.M.D.3
  • 12
    • 0037436176 scopus 로고    scopus 로고
    • Tracing the steps of Metastasis. Cancer's Menacing Ballet
    • Couzin J. (2003). Tracing the steps of Metastasis. Cancer's Menacing Ballet. Science 299, 1002-1006.
    • (2003) Science , vol.299 , pp. 1002-1006
    • Couzin, J.1
  • 13
    • 0035022174 scopus 로고    scopus 로고
    • Real-tine quantification in plasma of human telomerase reverse transcriptase (hTERT) mRNA: A simple blood test to monitor disease in cancer patients
    • Dasí F., Lledó S., García-Granero E., Ripoll R., Marugán M., Tormo M., García-Conde J. and Aliño S.F. (2001). Real-tine quantification in plasma of human telomerase reverse transcriptase (hTERT) mRNA: A simple blood test to monitor disease in cancer patients. Lab. Invest. 81, 767-769.
    • (2001) Lab. Invest. , vol.81 , pp. 767-769
    • Dasí, F.1    Lledó, S.2    García-Granero, E.3    Ripoll, R.4    Marugán, M.5    Tormo, M.6    García-Conde, J.7    Aliño, S.F.8
  • 14
    • 0038011863 scopus 로고    scopus 로고
    • Stem cells: Self-renewal writ in blood
    • Dick J.E. (2003). Stem cells: Self-renewal writ in blood. Nature 423, 231-233.
    • (2003) Nature , vol.423 , pp. 231-233
    • Dick, J.E.1
  • 15
    • 0034684662 scopus 로고    scopus 로고
    • Hematopoietic stem cells need two signals to prevent apoptosis; bcl-2 provide one of these, Kitl/c-kit signaling the other
    • Domen J. and Weissman I.L.(2000). Hematopoietic stem cells need two signals to prevent apoptosis; bcl-2 provide one of these, Kitl/c-kit signaling the other. J. Exp. Med. 192, 1707-1718.
    • (2000) J. Exp. Med. , vol.192 , pp. 1707-1718
    • Domen, J.1    Weissman, I.L.2
  • 16
    • 1842489906 scopus 로고    scopus 로고
    • Metastasis: The role of chance in malignancy
    • Edwards P.A. (2002). Metastasis: The role of chance in malignancy. Nature 418, 823.
    • (2002) Nature , vol.418 , pp. 823
    • Edwards, P.A.1
  • 17
    • 0018583976 scopus 로고
    • Clonal origin of human tumors
    • Fialkow P.J. (1979). Clonal origin of human tumors. Annu. Rev. Med. 30, 135-176.
    • (1979) Annu. Rev. Med. , vol.30 , pp. 135-176
    • Fialkow, P.J.1
  • 18
    • 0017704436 scopus 로고
    • Metastasis results from preexisting variant cells within a malignant tumor
    • Fidler I.J. and Kripke M.L. (1977). Metastasis results from preexisting variant cells within a malignant tumor. Science 197, 893-895.
    • (1977) Science , vol.197 , pp. 893-895
    • Fidler, I.J.1    Kripke, M.L.2
  • 19
    • 0035496104 scopus 로고    scopus 로고
    • APC, signal transduction and genetic instability in colorectal cancer
    • Fodde R., Smiths R. and Clevers H. (2001). APC, signal transduction and genetic instability in colorectal cancer. Nature Rev. Cancer 1, 55-67.
    • (2001) Nature Rev. Cancer , vol.1 , pp. 55-67
    • Fodde, R.1    Smiths, R.2    Clevers, H.3
  • 21
    • 0029074347 scopus 로고
    • Plasma DNA as a marker of cancerous cell death. Investigations in patients suffering from lung cancer and in nude mice bearing human tumors
    • Fournie G.J., Courtin J.P., Laval F., Chale J.J., Pourrat J.P., Pujazon M.C., Lauque D. and Carles P. (1995). Plasma DNA as a marker of cancerous cell death. Investigations in patients suffering from lung cancer and in nude mice bearing human tumors. Cancer Lett. 91, 221-227.
    • (1995) Cancer Lett. , vol.91 , pp. 221-227
    • Fournie, G.J.1    Courtin, J.P.2    Laval, F.3    Chale, J.J.4    Pourrat, J.P.5    Pujazon, M.C.6    Lauque, D.7    Carles, P.8
  • 22
    • 0032832654 scopus 로고    scopus 로고
    • Tumor DNA circulating in the plasma might play a role in metastasis. The hypothesis of the genometastasis
    • García-Olmo D., García-Olmo D.C., Ontañón J., Martinez E. and Vallejo M. (1999). Tumor DNA circulating in the plasma might play a role in metastasis. The hypothesis of the genometastasis. Histol. Histopathol. 14, 1159-1164.
    • (1999) Histol. Histopathol. , vol.14 , pp. 1159-1164
    • García-Olmo, D.1    García-Olmo, D.C.2    Ontañón, J.3    Martinez, E.4    Vallejo, M.5
  • 23
    • 0034650956 scopus 로고    scopus 로고
    • Horizontal transfer of DNA and the "genometastasis hypothesis"
    • García-Olmo D., García-Olmo D.C., Ontañón J. and Martinez E. (2000). Horizontal transfer of DNA and the " gEnometastasis hypothesis". Blood 95, 724-725.
    • (2000) Blood , vol.95 , pp. 724-725
    • García-Olmo, D.1    García-Olmo, D.C.2    Ontañón, J.3    Martinez, E.4
  • 24
    • 0034748198 scopus 로고    scopus 로고
    • Functionality of circulating DNA: The hypothesis of genometastasis
    • García-Olmo D. and García-Olmo D.C. (2001). Functionality of circulating DNA: The hypothesis of genometastasis. Ann. N. Y. Acad. Sci. 945,265-75.
    • (2001) Ann. N. Y. Acad. Sci. , vol.945 , pp. 265-275
    • García-Olmo, D.1    García-Olmo, D.C.2
  • 26
    • 18744402722 scopus 로고    scopus 로고
    • Modelling a new angle on understanding cancer
    • Gatenby R.A. and Maini P. (2002). Modelling a new angle on understanding cancer. Nature 420, 462.
    • (2002) Nature , vol.420 , pp. 462
    • Gatenby, R.A.1    Maini, P.2
  • 28
    • 0022973268 scopus 로고
    • Differentiation-linked leukemogenesis in lymphocytes
    • Greaves M.F. (1986). Differentiation-linked leukemogenesis in lymphocytes. Science 234, 697-704.
    • (1986) Science , vol.234 , pp. 697-704
    • Greaves, M.F.1
  • 29
    • 0034926031 scopus 로고    scopus 로고
    • Extracellular tyrosinase mRNA within apoptotic bodies is protected from degradation in human serum
    • Hasselmann D.O., Rappl G., Tilgen W. and Reinhold U. (2001). Extracellular tyrosinase mRNA within apoptotic bodies is protected from degradation in human serum. Clin. Chem. 47, 1488-1489.
    • (2001) Clin. Chem. , vol.47 , pp. 1488-1489
    • Hasselmann, D.O.1    Rappl, G.2    Tilgen, W.3    Reinhold, U.4
  • 30
    • 0031016323 scopus 로고    scopus 로고
    • Experimental coexpression of vimentin and keratin intermediate filaments in human breast cancer cells results in phenotypic interconversion and increased invasion behaviour
    • Hendrix M.J.C., Seftor E.A., Seftor R.E.B. and Trevor K.T. (1997). Experimental coexpression of vimentin and keratin intermediate filaments in human breast cancer cells results in phenotypic interconversion and increased invasion behaviour. Am. J. Pathol. 150, 483-495.
    • (1997) Am. J. Pathol. , vol.150 , pp. 483-495
    • Hendrix, M.J.C.1    Seftor, E.A.2    Seftor, R.E.B.3    Trevor, K.T.4
  • 31
    • 0034468330 scopus 로고    scopus 로고
    • Molecular biology of breast cancer metastasis. Molecular expression of vascular markers by aggressive breast cancer cells
    • Hendrix M.J.C., Seftor E.A., Kirschmann D. and Seftor R.E.B. (2000). Molecular biology of breast cancer metastasis. Molecular expression of vascular markers by aggressive breast cancer cells. Breast Cancer Res. 2, 417-422.
    • (2000) Breast Cancer Res. , vol.2 , pp. 417-422
    • Hendrix, M.J.C.1    Seftor, E.A.2    Kirschmann, D.3    Seftor, R.E.B.4
  • 33
    • 0035866393 scopus 로고    scopus 로고
    • DNA fragments in the blood plasma of cancer patients: Quantitations and evidence for their origin from apoptotic and necrotic cells
    • Jahr S., Hentze H., Englisch S., Hardt D., Fackelmayer F.O., Hesch R.D. and Knippers R. (2001). DNA fragments in the blood plasma of cancer patients: Quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res. 61, 1659-1665.
    • (2001) Cancer Res. , vol.61 , pp. 1659-1665
    • Jahr, S.1    Hentze, H.2    Englisch, S.3    Hardt, D.4    Fackelmayer, F.O.5    Hesch, R.D.6    Knippers, R.7
  • 36
    • 0036320933 scopus 로고    scopus 로고
    • Plasma nucleic acids in the diagnosis and management of malignant disease
    • Johnson P.J. and Lo Y.M.D. (2002). Plasma nucleic acids in the diagnosis and management of malignant disease. Clin. Chem. 48, 1186-1193.
    • (2002) Clin. Chem. , vol.48 , pp. 1186-1193
    • Johnson, P.J.1    Lo, Y.M.D.2
  • 37
    • 0020962307 scopus 로고
    • Carcinogenesis in relation to the stem-cell-mutation hypothesis
    • Kondo S. (1983). Carcinogenesis in relation to the stem-cell-mutation hypothesis. Differentiation 24, 1-8.
    • (1983) Differentiation , vol.24 , pp. 1-8
    • Kondo, S.1
  • 39
    • 0032802166 scopus 로고    scopus 로고
    • Detection of tumor messenger RNA in the serum of patients with malignant melanoma
    • Kopreski M.S., Benko F.A., Kwak L.W. and Gocke C.D. (1999). Detection of tumor messenger RNA in the serum of patients with malignant melanoma. Clin. Cancer Res. 5, 1961-1965.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1961-1965
    • Kopreski, M.S.1    Benko, F.A.2    Kwak, L.W.3    Gocke, C.D.4
  • 40
    • 0034616665 scopus 로고    scopus 로고
    • Somatic mutation screening: Identification of individuals harbouring k-ras mutations with the use of plasma DNA
    • Kopreski M.S., Benko F., Borys D.J., Khan A., McGarrity T.J. and Gocke C.D. (2000). Somatic mutation screening: Identification of individuals harbouring k-ras mutations with the use of plasma DNA. J. Nat. Cancer Inst. 92, 918-923.
    • (2000) J. Nat. Cancer Inst. , vol.92 , pp. 918-923
    • Kopreski, M.S.1    Benko, F.2    Borys, D.J.3    Khan, A.4    McGarrity, T.J.5    Gocke, C.D.6
  • 41
    • 0017360626 scopus 로고
    • Free DNA in the serum of cancer patients an the effect of the therapy
    • Leon S.A., Shapiro B., Sklaroff D.M. and Yaros M.J. (1977). Free DNA in the serum of cancer patients an the effect of the therapy. Cancer Res. 37, 646-650.
    • (1977) Cancer Res. , vol.37 , pp. 646-650
    • Leon, S.A.1    Shapiro, B.2    Sklaroff, D.M.3    Yaros, M.J.4
  • 42
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • Lessard J. and Sauvageau G. (2003). Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423, 255-60.
    • (2003) Nature , vol.423 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 44
    • 0037229767 scopus 로고    scopus 로고
    • Cancer's deadly signature
    • Liotta A.L. and Kohn E.C. (2003). Cancer's deadly signature. Nat. Genet. 33, 10-11.
    • (2003) Nat. Genet. , vol.33 , pp. 10-11
    • Liotta, A.L.1    Kohn, E.C.2
  • 45
    • 1842437594 scopus 로고    scopus 로고
    • Epstein-Barr virus (EBV) DNA in plasma and serum as a tumor marker for EBV-associated malignancies
    • Lo Y.M.D. Epstein-Barr virus (EBV) DNA in plasma and serum as a tumor marker for EBV-associated malignancies. (2000). JHKMTA 8, 1-5.
    • (2000) JHKMTA , vol.8 , pp. 1-5
    • Lo, Y.M.D.1
  • 46
    • 0037224378 scopus 로고    scopus 로고
    • Border-cell Migration: The race is on
    • Montell D.J. (2003). Border-cell Migration: The race is on. Nat. Rev. Mol. Cell. Biol. 14, 13-24.
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 13-24
    • Montell, D.J.1
  • 48
    • 0141907405 scopus 로고    scopus 로고
    • Telomerase as a target for cancer immunotherapy
    • Nguyen B., Elmore L.W. and Holt S.E. (2003). Telomerase as a target for cancer immunotherapy. Cancer Biol. Ther. 2, 131-136.
    • (2003) Cancer Biol. Ther. , vol.2 , pp. 131-136
    • Nguyen, B.1    Elmore, L.W.2    Holt, S.E.3
  • 49
    • 0026177265 scopus 로고
    • Tumor and host molecules important in the organ preference of metastasis
    • Nicolson G.L. (1991). Tumor and host molecules important in the organ preference of metastasis. Semin. Cancer Biol. 2, 143-154.
    • (1991) Semin. Cancer Biol. , vol.2 , pp. 143-154
    • Nicolson, G.L.1
  • 51
    • 0036328019 scopus 로고    scopus 로고
    • Organ- and tissue-specific stem cells and carcinogenesis
    • Pathak S. (2002). Organ- and tissue-specific stem cells and carcinogenesis. Anticancer Res. 22, 1353-1356.
    • (2002) Anticancer Res. , vol.22 , pp. 1353-1356
    • Pathak, S.1
  • 52
    • 0018864610 scopus 로고
    • The pathogenesis of cancer metastasis
    • Poste G. and Fidler I.J. (1980). The pathogenesis of cancer metastasis. Nature 283, 139-146.
    • (1980) Nature , vol.283 , pp. 139-146
    • Poste, G.1    Fidler, I.J.2
  • 54
    • 0141672711 scopus 로고
    • Elevated serum ribonuclease in patients with pancreatic cancer
    • Reddi K.K. and Holland J.F. (1976). Elevated serum ribonuclease in patients with pancreatic cancer. Proc. Natl. Acad. Sci. USA 73, 2308-2310.
    • (1976) Proc. Natl. Acad. Sci. USA , vol.73 , pp. 2308-2310
    • Reddi, K.K.1    Holland, J.F.2
  • 56
    • 0023927585 scopus 로고
    • RNA-lipid complexes released from the plasma membrane of human colon carcinoma cells
    • Rosi A., Guidoni L., Luciani A.M., Mariutti G. and Viti V. (1988). RNA-lipid complexes released from the plasma membrane of human colon carcinoma cells. Cancer Lett. 39, 153-160.
    • (1988) Cancer Lett. , vol.39 , pp. 153-160
    • Rosi, A.1    Guidoni, L.2    Luciani, A.M.3    Mariutti, G.4    Viti, V.5
  • 57
    • 0034017699 scopus 로고    scopus 로고
    • Serum mutant k-ras in the colorectal adenoma-to-carcinoma sequence. Implications for diagnosis, postoperative follow-up, and early detection of recurrent disease
    • Ryan B.M., McManus R.O., Daly J.S., Keeling P.W.N., Weir D.G., Lefort F. and Kelleher D. (2000). Serum mutant k-ras in the colorectal adenoma-to-carcinoma sequence. Implications for diagnosis, postoperative follow-up, and early detection of recurrent disease. Ann. N. Y. Acad. Sci. 906, 29-30.
    • (2000) Ann. N. Y. Acad. Sci. , vol.906 , pp. 29-30
    • Ryan, B.M.1    McManus, R.O.2    Daly, J.S.3    Keeling, P.W.N.4    Weir, D.G.5    Lefort, F.6    Kelleher, D.7
  • 58
    • 0026017392 scopus 로고
    • Leukemia and the disruption of normal hematopoiesis
    • Sawyers C.L., Denny C.T. and Witte O.N. (1991). Leukemia and the disruption of normal hematopoiesis. Cell 64, 337-350.
    • (1991) Cell , vol.64 , pp. 337-350
    • Sawyers, C.L.1    Denny, C.T.2    Witte, O.N.3
  • 61
    • 0028294877 scopus 로고
    • Maturation of stem cell differentiation is a common pathway the cellular origin of tetrocarcinomas and epithelial cancers
    • Sell S. and Pierce G.B. (1994). Maturation of stem cell differentiation is a common pathway the cellular origin of tetrocarcinomas and epithelial cancers. Lab. Invest. 70, 6-22.
    • (1994) Lab. Invest. , vol.70 , pp. 6-22
    • Sell, S.1    Pierce, G.B.2
  • 62
    • 0037057603 scopus 로고    scopus 로고
    • Metastasis: Objections to the same-gene model
    • Sherley J.L. (2002). Metastasis: Objections to the same-gene model. Nature 419, 560.
    • (2002) Nature , vol.419 , pp. 560
    • Sherley, J.L.1
  • 64
    • 0036282415 scopus 로고    scopus 로고
    • Detection of epithelial tumor RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumor cells
    • Silva J.M., Rodríguez R., García J.M., Muñoz C., Silva J., Domínguez G., Provencio, M., España P. and Bonilla F. (2002a). Detection of epithelial tumor RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumor cells. Gut 50, 530-534.
    • (2002) Gut , vol.50 , pp. 530-534
    • Silva, J.M.1    Rodríguez, R.2    García, J.M.3    Muñoz, C.4    Silva, J.5    Domínguez, G.6    Provencio, M.7    España, P.8    Bonilla, F.9
  • 66
    • 0034082024 scopus 로고    scopus 로고
    • Detection of mutated KRAS2 sequences as tumor markers in plasma/serum of patients with gastrointestinal cancer
    • Sorenson G.D. (2000). Detection of mutated KRAS2 sequences as tumor markers in plasma/serum of patients with gastrointestinal cancer. Clin. Cancer Res. 6, 2129-2137.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2129-2137
    • Sorenson, G.D.1
  • 68
  • 69
    • 0018081012 scopus 로고
    • Presence of RNA in the nucleoprotein complex spontaneously released by human lymphocytes and frog auricles in culture
    • Stroun M., Anker P., Beljanski M., Henri J., Lederrey C., Ojha M. and Maurice P.A. (1978). Presence of RNA in the nucleoprotein complex spontaneously released by human lymphocytes and frog auricles in culture. Cancer Res. 38, 3546-3554.
    • (1978) Cancer Res. , vol.38 , pp. 3546-3554
    • Stroun, M.1    Anker, P.2    Beljanski, M.3    Henri, J.4    Lederrey, C.5    Ojha, M.6    Maurice, P.A.7
  • 71
    • 0024420298 scopus 로고
    • Neoplastic characteristics of the DNA found in the plasma of cancer patients
    • Stroun M., Anker P., Maurice P., Lyautey J., Lederrey C. and Beljanski M. (1989). Neoplastic characteristics of the DNA found in the plasma of cancer patients. Oncology 46, 318-322.
    • (1989) Oncology , vol.46 , pp. 318-322
    • Stroun, M.1    Anker, P.2    Maurice, P.3    Lyautey, J.4    Lederrey, C.5    Beljanski, M.6
  • 73
    • 0034750966 scopus 로고    scopus 로고
    • Alu repeat sequences are present in increased proportions compared to a unique gene in plasma/serum DNA: Evidence for a preferential release from viable cells?
    • Stroun M., Lyautey J., Lederrey C., Mulcahy H.E. and Anker P. (2001). Alu repeat sequences are present in increased proportions compared to a unique gene in plasma/serum DNA: Evidence for a preferential release from viable cells? Ann. N. Y. Acad. Sci. 945, 258-264
    • (2001) Ann. N. Y. Acad. Sci. , vol.945 , pp. 258-264
    • Stroun, M.1    Lyautey, J.2    Lederrey, C.3    Mulcahy, H.E.4    Anker, P.5
  • 74
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog Wnt pathways in cancer
    • Taipale J. and Beachy P.A. (2001). The Hedgehog Wnt pathways in cancer. Nature 411, 349-54.
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 75
    • 0035499887 scopus 로고    scopus 로고
    • The development of neural stem cells
    • Temple S. (2001). The development of neural stem cells. Nature 414, 112-117.
    • (2001) Nature , vol.414 , pp. 112-117
    • Temple, S.1
  • 76
    • 0032724043 scopus 로고    scopus 로고
    • Association between keratin and vimentin expression, malignant phenotype, and survival in postmenopausal breast cancer patients
    • Thomas P.A., Kirschmann D.A., Cerhan J.R., Folberg R., Seftor E.A., Sellers T.A. and Hendrix M.J.C. (1999). Association between keratin and vimentin expression, malignant phenotype, and survival in postmenopausal breast cancer patients. Clin. Cancer Res. 5, 2698-2703.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2698-2703
    • Thomas, P.A.1    Kirschmann, D.A.2    Cerhan, J.R.3    Folberg, R.4    Seftor, E.A.5    Sellers, T.A.6    Hendrix, M.J.C.7
  • 77
    • 84987566227 scopus 로고
    • Stem cells in differentiation and neoplasia
    • Till J.T. (1982). Stem cells in differentiation and neoplasia. Cell Physiol. 1, 3-11.
    • (1982) Cell Physiol. , vol.1 , pp. 3-11
    • Till, J.T.1
  • 78
    • 0024399062 scopus 로고
    • Stem cell theory of carcinogenesis
    • Trosko J.E. and Chang C.C. (1989). Stem cell theory of carcinogenesis. Toxicol. Letters 49, 283-295.
    • (1989) Toxicol. Letters , vol.49 , pp. 283-295
    • Trosko, J.E.1    Chang, C.C.2
  • 79
    • 0036894648 scopus 로고    scopus 로고
    • A nucleolar mechanism controlling ell proliferation in stem cells and cancer cells
    • Tsai R.Y.L and McKay R.D.G. (2002). A nucleolar mechanism controlling ell proliferation in stem cells and cancer cells. Genes Dev. 16, 2991-3003.
    • (2002) Genes Dev. , vol.16 , pp. 2991-3003
    • Tsai, R.Y.L.1    McKay, R.D.G.2
  • 80
    • 0036336893 scopus 로고    scopus 로고
    • Stem-cell origin of metastasis and heterogeneity in solid tumors
    • Tu S.M., Lin S.H. and Logothetis C.J. (2002). Stem-cell origin of metastasis and heterogeneity in solid tumors. Lancet Oncol. 3, 508-513.
    • (2002) Lancet Oncol. , vol.3 , pp. 508-513
    • Tu, S.M.1    Lin, S.H.2    Logothetis, C.J.3
  • 81
    • 0028241030 scopus 로고
    • Point mutations of the N-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia
    • Vasioukhin V., Anker P., Maurice P., Lyautey J., Lederrey C. and Stroun M. (1994). Point mutations of the N-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia. Br. J. Haematol. 86, 774-779.
    • (1994) Br. J. Haematol. , vol.86 , pp. 774-779
    • Vasioukhin, V.1    Anker, P.2    Maurice, P.3    Lyautey, J.4    Lederrey, C.5    Stroun, M.6
  • 83
    • 0021844828 scopus 로고
    • Isolation and characterization of an RNA-proteolipid complex associated with the malignant state in humans
    • Wieczorek A.J., Rhyner C. and Block L.H. (1985). Isolation and characterization of an RNA-proteolipid complex associated with the malignant state in humans. Proc. Natl. Acad. Sci. USA 82, 3455-3459.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 3455-3459
    • Wieczorek, A.J.1    Rhyner, C.2    Block, L.H.3
  • 84
    • 0023475511 scopus 로고
    • Diagnostic and prognostic value of RNA-proteolipid in sera of patients with malignant disorders following therapy: First clinical evaluation of a novel tumor marker
    • Wieczorek A.J., Sitaramam V., Machleidt W., Rhyner K., Perruchoud A.P. and Block L.H. (1987). Diagnostic and prognostic value of RNA-proteolipid in sera of patients with malignant disorders following therapy: First clinical evaluation of a novel tumor marker. Cancer Res. 47, 6407-6412.
    • (1987) Cancer Res. , vol.47 , pp. 6407-6412
    • Wieczorek, A.J.1    Sitaramam, V.2    Machleidt, W.3    Rhyner, K.4    Perruchoud, A.P.5    Block, L.H.6


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