Activating and silencing histone modifications form independent allelic switch regions in the imprinted Gnas gene

Human Molecular Genetics

Volumn 13, Issue 7, 2004, Pages 741-750

  Li, Tao ^a   Vu, Thanh H ^a   Ulaner, Gary A ^a   Yang, Youwen ^a   Hu, Ji Fan ^a   Hoffman, Andrew R ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; HISTONE H3; LYSINE; PROTEIN GNAS1; TRANSCRIPTION ELONGATION FACTOR; UNCLASSIFIED DRUG;

ACETYLATION; ALLELE; ANIMAL CELL; ARTICLE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; EXON; FEMALE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE SEGREGATION; GENE SILENCING; GENE SWITCHING; GENETIC CODE; GENETIC POLYMORPHISM; GENOME IMPRINTING; IMMUNOPRECIPITATION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOSOME; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN METHYLATION; PROTEIN MODIFICATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ALLELES; ANIMALS; CHROMATIN; DNA METHYLATION; EXONS; FEMALE; FIBROBLASTS; GENE SILENCING; GENOMIC IMPRINTING; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HISTONES; IMMUNOPRECIPITATION; MALE; MICE; MICE, INBRED C57BL; MODELS, GENETIC; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; TRANSCRIPTION, GENETIC;

MUS; MUS SPRETUS;

EID: 1842533526     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddh081     Document Type: Article

References (35)

1. Liu, J., Yu, S., Litman, D., Chen, W. and Weinstein, L.S. (2000) Identification of a methylation imprint mark within the mouse Gnas locus. Mol. Cell. Biol., 20, 5808-5817.
2. Wroe, S.F., Kelsey, G., Skinner, J.A., Bodle, D., Ball, S.T., Beechey, C.V., Peters, J. and Williamson, C.M. (2000) An imprinted transcript, antisense to Nesp, adds complexity to the cluster of unprinted genes at the mouse Gnas locus. Proc. Natl Acad. Sci., USA, 97, 3342-3346.
3. Li, T., Vu, T.H., Zeng, Z.L., Nguyen, B.T., Hayward, B.E., Bonthron, D.T., Hu, J.F. and Hoffman, A.R. (2000) Tissue-specific expression of antisense and sense transcripts at the imprinted Gnas locus. Genomics, 69, 295-304.
4. Hayward, B.E., Moran, V., Strain, L. and Bonthron, D.T. (1998) Bidirectional imprinting of a single gene: GNAS1 encodes maternally, paternally, and biallelically derived proteins. Proc. Natl Acad. Sci. USA, 95, 15 475-15 480.
5. Peters, J., Wroe, S.F., Wells, C.A., Miller, H.J., Bodle, D., Beechey, C.V., Williamson, C.M. and Kelsey, G. (1999) A cluster of oppositely imprinted transcripts at the Gnas locus in the distal imprinting region of mouse chromosome 2. Proc. Natl Acad. Sci. USA, 96, 3830-3835.
6. Belotserkovskaya, R., Oh, S., Bondarenko, V.A., Orphanides, G., Studitsky, V.M. and Reinberg, D. (2003) FACT facilitates transcription-dependent nucleosome alteration. Science, 301, 1090-1093.
7. Saunders, A., Werner, J., Andrulis, E.D., Nakayama, T., Hirose, S., Reinberg, D. and Lis, J.T. (2003) Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo. Science, 301, 1094-1096.
8. Kaplan, C.D., Laprade, L. and Winston, F. (2003) Transcription elongation factors repress transcription initiation from cryptic sites. Science, 301, 1096-1099.
9. Svejstrup, J.Q. (2003) Transcription. Histones face the FACT. Science, 301, 1053-1055.
10. Jenuwein, T. and Allis, C.D. (2001) Translating the histone code. Science, 293, 1074-1080.
11. Spotswood, H.T. and Turner, B.M. (2002) An increasingly complex code. J. Clin. Invest., 110, 577-582.
12. Grewal, S.I. and Moazed, D. (2003) Heterochromatin and epigenetic control of gene expression. Science, 301, 798-802.
13. Litt, M.D., Simpson, M., Gaszner, M., Allis, C.D. and Felssenfeld, G. (2001) Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus. Science, 293, 2453-2455.
14. Hu, J.F., Pham, J., Dey, I., Li, T., Vu, T.H. and Hoffman, A.R. (2000) Allele-specific histone acetylation accompanies genomic imprinting of the insulin-like growth factor II receptor gene. Endocrinology, 141, 4428-4435.
15. Gregory, R.I., Randall, T.E., Johnson, C.A., Khosla, S., Hatada, I., O'Neill, L.P., Turner, B.M. and Feil, R. (2001) DNA methylation is linked to deacetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2af1-rs1. Mol. Cell. Biol., 21, 5426-5436.
16. Bernstein, B.E., Humphrey, E.L., Erlich, R.L., Schneider, R., Bouman, P., Liu, J.S., Kouzarides, T. and Schreiber, S.L. (2002) Methylation of histone H3 Lys 4 in coding regions of active genes. Proc. Natl Acad. Sci. USA, 99, 8695-8700.
17. Santos-Rosa, H., Schneider, R., Bannister, A.J., Sherriff, J., Bernstein, B.E., Emre, N.C., Schreiber, S.L., Mellor, J. and Kouzarides, T. (2002) Active genes are tri-methylated at K4 of histone H3. Nature, 419, 407-411.
18. Li, T., Vu, T.H., Lee, K.O., Yang, Y., Nguyen, C.V., Bui, H.Q., Zeng, Z.L., Nguyen, B.T., Hu, J.F., Murphy, S.K. et al. (2002) An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. J. Biol. Chem., 277, 13 518-13 527.
19. Coombes, C., Arnaud, P., Gordon, E., Dean, W., Coar, E.A., Williamson, C.M., Feil, R., Peters, J. and Kelsey, G. (2003) Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus. Mol. Cell. Biol., 23, 5475-5488.
20. Pedone, P.V., Pikaart, M.J., Cerrato, F., Vernucci, M., Ungaro, P., Bruni, C.B. and Riccio, A. (1999) Role of histone acetylation and DNA methylation in the maintenance of the imprinted expression of the H19 and Igf2 genes. FEBS Lett., 458, 45-50.
21. Grandjean, V., O'Neill, L., Sado, T., Turner, B. and Ferguson-Smith, A. (2001) Relationship between DNA methylation, histone H4 acetylation and gene expression in the mouse imprinted Igf2-H19 domain, FEBS Lett., 488, 165-169.
22. Perk, J., Makedonski, K., Lande, L., Cedar, H., Razin, A. and Shemer, R. (2002) The imprinting mechanism of the Prader-Willi/Angelman regional control center. EMBO J., 21, 5807-5814.
23. Fournier, C., Goto, Y., Ballestar, E., Delaval, K., Hever, A.M., Esteller, M. and Feil, R. (2002) Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes. EMBO J., 21, 6560-6570.
24. Xin, Z., Allis, C.D. and Wagstaff, J. (2001) Parent-specific complementary patterns of histone H3 lysine 9 and H3 lysine 4 methylation at the Prader-Willi syndrome imprinting center. Am. J. Hum. Genet., 69, 1389-1394.
25. Yang, Y., Li, T., Vu, T.H., Ulaner, G.A., Hu, J.F. and Hoffman, A.R. (2003) The histone code regulating expression of the imprinted mouse Igf2r gene. Endocrinology, 144, 5658-5670.
26. Maison, C., Bailly, D., Peters, A.H., Quivy, J.P., Roche, D., Taddei, A., Lachner, M., Jenuwein, T. and Almouzni, G. (2002) Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component. Nat. Genet., 30, 329-334.
27. West, A.G., Gaszner, M. and Felsenfeld, G. (2002) Insulators: many functions, many mechanisms. Genes Dev., 16, 271-288.
28. Kimura, A., Umehara, T. and Horikoshi, M. (2002) Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing. Nat. Genet., 32, 370-377.
29. Suka, N., Luo, K. and Grunstein, M. (2002) Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin. Nat. Genet., 32, 378-383.
30. Wang, A., Kurdistani, S.K. and Grunstein, M. (2002) Requirement of Hos2 histone deacetylase for gene activity in yeast. Science, 298, 1412-1414.
31. Wutz, A., Smrzka, O.W., Schweifer, N., Schellander, K., Wagner, E.F. and Barlow, D.P. (1997) Imprinted expression of the Igf2r gene depends on an intronic CpG island. Nature, 389, 745-749.
32. Nakabayashi, K., Bentley, L., Hitchins, M.P., Mitsuya, K., Meguro, M., Minagawa, S., Bamforth, J.S., Stanier, P., Preece, M., Weksberg, R. et al. (2002) Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32. Hum. Mol. Genet., 11, 1743-1756.
33. Hu, J.F., Vu, T.H. and Hoffman, A.R. (1996) Promoter-specific modulation of insulin-like growth factor II genomic imprinting by inhibitors of DNA methylation. J. Biol. Chem., 271, 18 253-18 262.
34. Hall, I.M., Shankaranarayana, G.D., Noma, K., Ayoub, N., Cohen, A. and Grewal, S.I. (2002) Establishment and maintenance of a heterochromatin domain. Science, 297, 2232-2237.
35. Xiong, Z. and Laird, P.W. (1997) COBRA: A sensitive and quantitative DNA methylation assay. Nucl. Acids Res., 25, 2532-2534.