1H MRSI evidence of metabolic abnormalities in childhood-onset schizophrenia

NeuroImage

Volumn 21, Issue 4, 2004, Pages 1781-1789

  O'Neill, Joseph ^a   Levitt, Jennifer ^a   Caplan, Rochelle ^a   Asarnow, Robert ^a   McCracken, James T ^a   Toga, Arthur W ^a   Alger, Jeffry R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anterior cingulate; Childhood onset schizophrenia; Frontal cortex; Magnetic resonance spectroscopy; Striatum

Indexed keywords

ACETIC ACID DERIVATIVE; CHOLINE DERIVATIVE; CREATINE; CREATINE PHOSPHATE; ASPARTIC ACID; CHOLINE; DRUG DERIVATIVE; N ACETYLASPARTIC ACID; N-ACETYLASPARTATE;

ADOLESCENT; ARTICLE; BRAIN REGION; CAUDATE NUCLEUS; CELL ENERGY; CHILDHOOD; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ECHOGRAPHY; EVIDENCE BASED MEDICINE; FEMALE; FRONTAL CORTEX; HEMISPHERE; HUMAN; IMAGE ANALYSIS; IMAGING SYSTEM; INTERMETHOD COMPARISON; MALE; METABOLIC DISORDER; NEUROIMAGING; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SCHIZOPHRENIA; SCHOOL CHILD; SEX DIFFERENCE; STATISTICAL ANALYSIS; THALAMUS; AGE; BRAIN; BRAIN MAPPING; CHILD; COMPUTER ASSISTED DIAGNOSIS; ENERGY METABOLISM; FRONTAL LOBE; HEMISPHERIC DOMINANCE; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; REFERENCE VALUE;

ADOLESCENT; AGE FACTORS; ASPARTIC ACID; BRAIN; BRAIN MAPPING; CAUDATE NUCLEUS; CHILD; CHOLINE; CREATINE; DOMINANCE, CEREBRAL; ENERGY METABOLISM; FRONTAL LOBE; GYRUS CINGULI; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHOCREATINE; REFERENCE VALUES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SEX FACTORS; THALAMUS;

EID: 1842452095     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2003.11.005     Document Type: Article

References (78)

1. Aiken N.R., Gillies R.J. Phosphomonoester metabolism as a function of cell proliferative status and exogenous precursors. Anticancer Res. 16:1996;1393-1397.
2. Ananth H., Popescu I., Critchley H.D., Good C.D., Frackowiak R.S.J., Dolan R.J. Cortical and subcortical gray matter abnormalities in schizophrenia determined through structural magnetic resonance imaging with optimized voxel-based morphometry. Am. J. Psychiatry. 159:2002;1497-1505.
3. Asarnow A.R., Asarnow J.R. Childhood onset schizophrenia: editor's introduction. Schizophr. Bull. 20:1994;591-597.
4. Asarnow R.F., Nuechterlein K.H., Fogelson D., Subotnik K.J., Payne D.A., Russell A.T., Asamen J., Kuppinger H., Kendler K.S. Schizophrenia and schizophrenia-spectrum personality disorders in the first-degree relatives of children with schizophrenia: the UCLA family study. Arch. Gen. Psychiatry. 58:2001;581-588.
5. 1H-MRS and tissue segmentation. Schizophr. Res. 52:2001;87-99.
6. Aylward E., Walker E., Bettes B. Intelligence in schizophrenia: meta-analysis of the research. Schizophr. Bull. 10(3):1984;430-459.
7. Bertolino A., Weinberger D.R. Proton magnetic resonance spectroscopy in schizophrenia. Eur. J. Radiol. 30:1999;132-141.
8. Bertolino A., Kumra S., Callicott J.H., Mattay V.S., Lestz R.M., Jacobsen L., Barnett I.S., Duyn J.H., Frank J.A., Rapoport J.L., Weinberger D.R. Common pattern of cortical pathology in childhood-onset and adult-onset schizophrenia as identified by proton magnetic resonance spectroscopic imaging. Am. J. Psychiatry. 155:1998;1376-1383.
9. 1H-NMR spectroscopic studies of brain. Neurosci. Biobehav. Rev. 13(1):1989;23-31.
10. Blanton R.E., Levitt J.G., Thompson P.M., Narr K.L., Capetillo-Cunliffe L., Nobel A., Singerman J.D., McCracken J.T., Toga A.W. Mapping cortical asymmetry and complexity patterns in normal children. Psychiatry Res.: Neuroimaging. 107:2001;29-43.
11. Block W., Bayer T.A., Tepest R., Träber F., Rietschel M., Müller D.J., Schulze T.G., Honer W.G., Maier W., Schild H.H., Falkai P. Decreased frontal lobe ratio of N-acetyl aspartate to choline in familial schizophrenia: a proton magnetic resonance spectroscopy study. Neurosci. Lett. 289:2000;147-151.
12. 31P MRS of the schizophrenic brain in vivo. J. Comput. Assist. Tomogr. 23:1999;272-275.
13. Brand A., Richter-Landsberg C., Leibfritz D. Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev. Neurosci. 15:1993;289-298.
14. Brooks W.M., Hodde-Vargas J., Vargas L.A., Yeo R.A., Ford C.C., Hendren R.L. Frontal lobe of children with schizophrenia spectrum disorders: a proton magnetic resonance spectroscopic study. Biol. Psychiatry. 43:1998;263-269.
15. 1H magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: clinical, neurodevelopmental, and cognitive correlates. Biol. Psychiatry. 36:1994;792-800.
16. Bustillo J.R., Lauriello J., Rowland L.M., Jung R.E., Petropoulos H., Hart B.L., Blanchard J., Keith S.J., Brooks W.M. Effects of chronic haloperidol and clozapine treatments on frontal and caudate neurochemistry in schizophrenia. Psychiatry Res.: Neuroimaging. 107:2001;135-149.
17. Cecil K.M., Lenkinski R.E., Gur R.E., Gur R.C. Proton magnetic resonance spectroscopy in the frontal and temporal lobes of neuroleptic naïve patients with schizophrenia. Neuropsychopharmacology. 20(2):1999;131-140.
18. Corson P.W., Nopoulos P., Miller D.D., Arndt S., Andreasen N.C. Change in basal ganglia volume over 2 years in patients with schizophrenia: typical versus atypical neuroleptics. Am. J. Psychiatry. 156:1999;1200-1204.
19. Davidson M., Weiser M. Early diagnosis of schizophrenia - The first step towards secondary prevention. Acta Psychiatr. Scand. Suppl. 400:2000;7-10.
20. Davies N., Russell A., Jones P., Murray R.M. Which characteristics of schizophrenia predate psychosis? J. Psychiatr. Res. 32(3-4):1998;121-131.
21. Deicken R.F., Johnson C., Elias Y., Schuff N. Reduced concentrations of thalamic N-acetylaspartate in male patients with schizophrenia. Am. J. Psychiatry. 157:2000;644-647.
22. Deicken R.F., Johnson C., Pegues M. Proton magnetic resonance spectroscopy of the human brain in schizophrenia. Rev. Neurosci. 11:2000;147-158.
23. Delamillieure P., Constans J.-M., Fernandez J., Dollfus S. Apport de la spectroscopie par résonance magnétique dans la schizophrénie. L'Encéphale. XXVI:2000;21-31.
24. Delamillieure P., Constans J.-M., Fernandez J., Brazo P., Benali K., Courtheoux P., Thibaut F., Petit M., Dollfus S. Proton magnetic resonance spectroscopy (1H MRS) in schizophrenia: investigation of the right and left hippocampus, thalamus, and prefrontal cortex. Schizophr. Bull. 28(2):2002;329-339.
25. Duyn J.H., Gillen J., Sobering G., van Zijl P.C., Moonen C.T.W. Multisection proton MR spectroscopic imaging of the brain. Radiology. 188:1993;277-282.
26. Ende G., Braus D.F., Walter S., Henn F.A. Lower concentration of thalamic N-acetylaspartate in patients with schizophrenia: a replication study. Am. J. Psychiatry. 158:2001;1314-1316.
27. Fenton W.S., Hibbeln J., Knable M. Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia. Biol. Psychiatry. 47:2000;8-21.
28. Frith C.D. The cognitive abnormalities underlying the symptomatology and the disability of patients with schizophrenia. Int. Clin. Psychopharmacol. 10(Suppl. 3):1995;87-98.
29. Fujimoto T., Nakano T., Takano T., Takeuchi K., Yamada K., Fukuzako T., Akimoto H. Proton magnetic resonance spectroscopy of basal ganglia in chronic schizophrenia. Biol. Psychiatry. 40:1996;14-18.
30. Fukuzako H., Takeuchi K., Hokazono Y., Fukuzako T., Yamada K., Hashiguchi T., Obo Y., Ueyama K., Takigawa M., Fujimoto T. Proton magnetic resonance spectroscopy of the left medial temporal and frontal lobes in chronic schizophrenia: preliminary report. Psychiatry Res. 61:1995;193-200.
31. Fukuzako H., Fukuzako T., Hashiguchi T., Kodama S., Takigawa M., Fujimoto T. Changes in levels of phosphorus metabolites in temporal lobes of drug-naïve schizophrenic patients. Am. J. Psychiatry. 156:1999;1205-1208.
32. Gilbert A.R., Rosenberg D.R., Harenski K., Spencer S., Sweeney J.A., Keshavan M.S. Thalamic volumes in patients with first-episode schizophrenia. Am. J. Psychiatry. 158:2001;618-624.
33. Gill S.S., Thomas D.G., Van Bruggen N., Gadian D.G., Peden C.J., Bell J.D., Cox I.J., Menon D.K., Iles R.A., Bryant D.J. Proton MR spectroscopy of intracranial tumours: in vivo and in vitro studies. J. Comput. Assist. Tomogr. 14:1990;497-504.
34. Gupta R.K., Cloughesy T.F., Sinha U., Garakian J., Rubino G., Rubino L., Becker D.P., Vinters H.V., Alger J.R. Relationships between choline magnetic resonance spectroscopy, apparent diffusion coefficient and quantitative histopathology in human glioma. J. Neuro-Oncol. 50:2000;215-226.
35. Haase A., Frahm J., Hänicke W., Matthaei D. 1H NMR chemical shift selective (CHESS) imaging. Phys. Med. Biol. 30(4):1985;341-344.
36. Hakak Y., Walker J.R., Li C., Wong W.H., Davis K.L., Buxbaum J.D., Haroutunian V., Fienberg A.A. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc. Natl. Acad. Sci. 98(8):2001;4746-4751.
37. Hendren R.L., De Backer I., Pandina G.J. Review of neuroimaging studies of child and adolescent psychiatric disorders from the past 10 years. J. Am. Acad. Child Adolesc. Psych. 39:2000;815-828.
38. Hof P.R., Haroutunian V., Copland C., Davis K.L., Buxbaum J.D. Molecular and cellular evidence for an oligodendrocyte abnormality in schizophrenia. Neurochem. Res. 27(10):2002;1193-1200.
39. Hof P.R., Haroutunian V., Friedrich V.L. Jr., Byne W., Buitron C., Perl D.P., Davis K.L. Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia. Biol. Psychiatry. 53:2003;1075-1085.
40. Hokama H., Shenton M.E., Nestor P.G., Kikinis R., Levitt J.J., Metcalf D., Wible C.G., O'Donnell B.F., Jolesz F.A., McCarley R.W. Caudate, putamen, and globus pallidus volume in schizophrenia: a quantitative MRI study. Psychiatry Res. 61:1995;209-229.
41. Horrobin D.F., Glen M., Vaddadi K. The membrane hypothesis of schizophrenia. Schizophr. Res. 13:1994;195-207.
42. Kaufman J., Birmaher B., Brent D., Rao U., Flynn C., Moreci P., Williamson D., Ryan N. Schedule for affective disorders and schizophrenia for school age children present and lifetime version (K-SADS-PL): initial reliability and validity data. J. Am. Acad. Child Adolesc. Psych. 36(7):1997;980-988.
43. Kegeles L.S., Humaran T.J., Mann J.J. In vivo neurochemistry of the brain in schizophrenia as revealed by magnetic resonance spectroscopy. Biol. Psychiatry. 44:1998;382-398.
44. Kelly J., Murray R.M. What risk factors tell us about the causes of schizophrenia and related psychoses. Curr. Psychiatry Rep. 2(5):2000;378-385.
45. Keshavan M.S., Rosenberg D., Sweeney J.A., Pettegrew J.W. Decreased caudate volume in neuroleptic-naïve schizophrenics. Am. J. Psychiatry. 155:1998;774-778.
46. Keshavan M.S., Stanley J.A., Pettegrew J.W. Magnetic resonance spectroscopy in schizophrenia: methodological issues and findings - Part II. Biol. Psychiatry. 48:2000;369-380.
47. Kumra S., Giedd J.N., Vaituzis A.C., Jacobsen L.K., McKenna K., Bedwell J., Hamburger S., Nelson J.E., Lenane M., Rapoport J.L. Childhood-onset psychotic disorders: magnetic resonance imaging of volumetric differences in brain structure. Am. J. Psychiatry. 157:2000;1467-1474.
48. Lang D.J., Kopala L.C., Vandorpe R.A., Rui Q., Smith G.N., Goghari V.M., Honer W.G. An MRI study of basal ganglia volumes in first-episode schizophrenia patients treated with risperidone. Am. J. Psychiatry. 158:2001;625-631.
49. Lawrie S.M., Abukmeil S.S. Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies. Br. J. Psychiatry. 172:1998;110-120.
50. Levitt J.G., Blanton R.E., Caplan R., Asarnow R., Guthrie D., Toga A.W., Capetillo-Cunliffe L., McCracken J.T. Medial temporal lobe in childhood-onset schizophrenia. Psychiatry Res: Neuroimaging. 108:2001;17-27.
51. Matsumoto H., Simmons A., Williams S., Hadjulis M., Pipe R., Murray R., Frangou S. Superior temporal gyrus abnormalities in early onset schizophrenia: similarities and differences with adult-onset schizophrenia. Am. J. Psychiatry. 158:2001;1299-1304.
52. Matsumoto H., Simmons A., Williams S., Pipe R., Murray R., Frangou S. Structural magnetic imaging of the hippocampus in early onset schizophrenia. Biol. Psychiatry. 49:2001;824-831.
53. McCarley R.W., Wible C.G., Frumin M., Hirayasu Y., Levitt J.J., Fischer I.A., Shenton M.E. MRI anatomy of schizophrenia. Biol. Psychiatry. 45:1999;1099-1119.
54. Mehler C., Warnke A. Structural brain abnormalities specific to childhood-onset schizophrenia identified by neuroimaging techniques. J. Neural Transm. 109(2):2002;219-234.
55. Miller B.L., Chang L., Booth R., Ernst T., Cornford M., Nikas D., McBride D., Jenden D.J. In vivo 1H MRS choline: correlation with in vitro chemistry/histology. Life Sci. 58:1996;1929-1935.
56. 1H-magnetic resonance spectroscopy of postmortem brains with schizophrenia. Biol. Psychiatry. 42:1997;359-366.
57. Omori M., Murata T., Kimura H., Koshimoto Y., Kado H., Ishimori Y., Ito H., Wada Y. Thalamic abnormalities in patients with schizophrenia revealed by proton magnetic resonance spectroscopy. Biol. Psychiatry Res. Neuroimaging. 98:2000;155-162.
58. Petroff O.A.C., Errante L.D., Kim J.H., Spencer D.D. N-acetyl-aspartate, total creatine, and myo-inositol in the epileptogenic human hippocampus. Neurology. 60:2003;1646-1651.
59. Portas C.M., Goldstein J.M., Shenton M.E., Hokama H.H., Wible C.G., Fischer I., Kikinis R., Donnino R., Jolesz F.A., McCarley R.W. Volumetric evaluation of the thalamus in schizophrenic male patients using magnetic resonance imaging. Biol. Psychiatry. 43:1998;649-659.
60. Rajkowska G., Miguel-Hidalgo J.J., Makkos Z., Meltzer H., Overholser J., Stockmeier C. Layer-specific reductions in GFAP-reactive astroglia in the dorsolateral prefrontal cortex in schizophrenia. Schizophr. Res. 57:2002;127-138.
61. Rapoport J.L., Castellanos F.X., Gogate N., Janson K., Kohler S., Nelson P. Imaging normal and abnormal brain development: new perspectives for childhood-onset schizophrenia: progressive ventricular change during adolescence. Arch. Gen. Psychiatry. 54:2001;897-903.
62. Shapleske J., Rossell S.I., Chitnis X.A., Suckling J., Simmons A., Bullmore E.T., Woodruff P.W.R., David A.S. A computational morphometric MRI study of schizophrenia: effects of hallucinations. Cereb. Cortex. 12:2002;1331-1341.
63. Shihabuddin L., Buchsbaum M.S., Hazlett E.A., Silverman J., New A., Brickman A.M., Mitropoulou V., Nunn M., Fleischman M.B., Tang C., Siever L.J. Striatal size and glucose metabolic rate in schizotypal personality disorder and schizophrenia. Arch. Gen. Psychiatry. 58:2001;877-884.
64. Shioiri T., Hamakawa H., Kato T., Murashita J., Fuji K., Inubushi T., Takahasji S. Proton magnetic resonance spectroscopy of the basal ganglia in patients with schizophrenia: a preliminary report. Schizophr. Res. 22:1996;19-26.
65. Siesjö B.K. Brain Energy Metabolism. 1978;Wiley, Chichester.
66. Sowell E.R., Thompson P.M., Holmes C.J., Batth R., Jernigan T.L., Toga A.W. Localizing age-related changes in brain structure between childhood and adolescence using statistical parametric mapping. NeuroImage. 9:1999;587-597.
67. Sowell E.R., Toga A.W., Asarnow R. Brain abnormalities observed in childhood-onset schizophrenia: a review of the structural magnetic resonance imaging literature. Ment. Retard. Dev. Disabil. 6:2000;180-185.
68. Speck O., Thiel T., Hennig J. Grading and therapy monitoring of astrocytomas with 1H-spectroscopy: preliminary study. Anticancer Res. 16:1996;1581-1585.
69. Tekin S., Cummings J.L. Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update. J. Psychosom. Res. 53:2002;647-654.
70. 1H MR spectroscopy in childhood-onset schizophrenia. J. Med. Res. Inst. 8:1998;841-846.
71. Urenjak J., Williams S.R., Gadian D.G., Noble M. Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. J. Neurochem. 59:1992;55-61.
72. Urenjak J., Williams S.R., Gadian D.G., Noble M. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J. Neurosci. 13(3):1993;981-989.
73. Volz H.-P., Gaser C., Sauer H. Supporting evidence for the model of cognitive dysmetria in schizophrenia - A structural magnetic resonance imaging study using deformation-based morphometry. Schizophr. Res. 46:2000;45-56.
74. 31Phosphorus magnetic resonance spectroscopy of the dorsolateral prefrontal region in schizophrenics - a study including 50 pateints and 36 controls. Biol. Psychiatry. 44(6):1998;399-404.
75. Wechsler D. Wechsler Intelligence Scale for Children-Revised (WISC-R). 1974;Psychological Corporation, New York.
76. Woods R.P., Mazziotta J.C., Cherry S.R. MRI-PET registration with automated algorithm. J. Comput. Assist. Tomogr. 17:1993;536-546.
77. Wright I.C., Rabe-Hesketh S., Woodruff P.W.R., David A.S., Murray R.M., Bullmore E.T. Meta-analysis of regional brain volumes in schizophrenia. Am. J. Psychiatry. 157:2000;16-25.
78. 1H-MR spectroscopy and gray matter volume of the anterior cingulate cortex in schizophrenia. NeuroReport. 13(16):2002;2133-2137.