Changes in levels of phosphorus metabolites in temporal lobes of drug- naive schizophrenic patients

American Journal of Psychiatry

Volumn 156, Issue 8, 1999, Pages 1205-1208

  Fukuzako, Hiroshi ^a,b   Fukuzako, Tsuyoshi ^a   Hashiguchi, Tomo ^a   Kodama, Satoshi ^a   Takigawa, Morikuni ^a   Fujimoto, Toshiro ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE PHOSPHATE; MEMBRANE PHOSPHOLIPID; PHOSPHORUS;

ADULT; ARTICLE; BRAIN LEVEL; BRAIN METABOLISM; CLINICAL ARTICLE; ENERGY METABOLISM; FEMALE; HUMAN; MALE; METABOLITE; PHOSPHATE METABOLISM; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SCHIZOPHRENIA; TEMPORAL LOBE;

ADULT; ANALYSIS OF VARIANCE; BRIEF PSYCHIATRIC RATING SCALE; ESTERS; ETHANOLAMINES; FEMALE; FUNCTIONAL LATERALITY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PHOSPHOCREATINE; PHOSPHOLIPIDS; PHOSPHORUS; PHOSPHORUS ISOTOPES; PHOSPHORYLCHOLINE; SCHIZOPHRENIA; TEMPORAL LOBE;

EID: 0032854768     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. McClure RJ, Keshavan MS, Pettegrew JW: Chemical and physiologic brain imaging in schizophrenia. Psychiatr Clin North Am 1998; 21:93-122
2. Pettegrew JW, Keshavan MS, Panchalingam K, Strychor S, Kaplan DB, Tretta MG, Allen M: Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics: a pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy. Arch Gen Psychiatry 1991; 48:563-568
3. Stanley JA, Williamson PC, Drost DJ, Carr TJ, Rylett RJ, Malla A, Thompson RT: An in vivo study of the prefrontal cortex of schizophrenic patients at different stages of illness via phosphorus magnetic resonance spectroscopy. Arch Gen Psychiatry 1995; 52:399-406
4. 31Phosphorus magnetic resonance spectroscopy of the frontal and parietal lobes in chronic schizophrenia. Biol Psychiatry 1994; 36:503-510
5. Kegeles LS, Humaran TJ, Mann JJ: In vivo neurochemistry of the brain in schizophrenia as revealed by magnetic resonance spectroscopy. Biol Psychiatry 1998; 44:382-398
6. 1H decoupling (abstract), in Proceedings of the 4th Scientific Meeting of the International Society for Magnetic Resonance in Medicine. New York, ISMRM, 1996, p 998
7. 31Phosphorus magnetic resonance spectroscopy of the dorsolateral prefrontal region in schizophrenics - a study including 50 patients and 36 controls. Biol Psychiatry 1998; 44:399-404
8. 31phosphorus magnetic resonance spectroscopic imaging study. Biol Psychiatry 1995; 38:279-286
9. Fukuzako H, Fukuzako T, Takeuchi K, Ohbo Y, Ueyama K, Takigawa M, Fujimoto T: Phosphorus magnetic resonance spectroscopy in schizophrenia: correlation between membrane phospholipid metabolism in the temporal lobe and positive symptoms. Prog Neuropsychopharmacol Biol Psychiatry 1996;20:629-640
10. Horrobin DF: The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia. Schizophr Res 1998; 30:193-208
11. 31P-MRS. Japanese J Magnetic Resonance in Medicine 1992; 12:232-237
12. 31P NMR spectra of the human brain in vivo. NMR Biomed 1994; 7:237-242
13. 31P NMR spectrum of human brain: the determination of the concentrations of phosphodiester components. FEBS Lett 1990; 272:163-165
14. Stanley JA, Panchalingam K, Miller G, McClure RJ, Pettegrew JW: A new method to quantify the broad component under the phosphodiester resonance and its application to study first-episode never medicated schizophrenics (abstract), in Proceedings of the 5th Scientific Meeting of the International Society for Magnetic Resonance in Medicine. Vancouver, ISMRM, 1997, p 1408
15. Blüml S, Tan J, Adatia N, Karme A, Sproull T, Harris K, Ross BD: Cerebral glycerophosphorylcholine and ethanolamine concentrations are elevated in young schizophrenics (abstract), in Proceedings of the 6th Scientific Meeting of the International Society for Magnetic Resonance in Medicine. Sydney, ISMRM, 1998, p 736
16. Lawrie SM, Abukmeil SS: Brain abnormality in schizophrenia: a systematic and quantitative review of volumetric magnetic resonance imaging studies. Br J Psychiatry 1998; 172:110-120
17. 31P magnetic resonance spectroscopy. J Cereb Blood Flow Metab 1992; 12: 584-592
18. Russell JM, Early TS, Patterson JC, Martin JL, Villanneva-Meyer J, McGee MD: Temporal lobe perfusion asymmetries in schizophrenia. J Nucl Med 1997; 38:607-612
19. Deicken RF, Calabrese G, Merrin EL, Fein G, Weiner MW: Basal ganglia phosphorous metabolism in chronic schizophrenia. Am J Psychiatry 1995; 152:126-129