Serotonin Transporter Polymorphism and Depressive-Related Symptoms in Schizophrenia

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 126 B, Issue 1, 2004, Pages 1-7

  Golimbet, V E ^a,b   Alfimova, M V ^a,b   Shchebatykh, T V ^a,b   Abramova, L I ^a,b   Kaleda, V G ^a,b   Rogaev, E I ^a,b  

^a MENTAL HEALTH RESEARCH CENTER   (Russian Federation)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Clinical symptoms; PANSS; Personality traits; Serotonin transporter

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ANXIETY; ARTICLE; CLINICAL FEATURE; DEPRESSION; FEMALE; GENE DELETION; GENE INSERTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; GUILT; HEREDITY; HUMAN; INTERNATIONAL CLASSIFICATION OF DISEASES; MAJOR CLINICAL STUDY; MALE; MOLECULAR GENETICS; NEGATIVE SYNDROME; PERSONALITY; POSITIVE SYNDROME; PRIORITY JOURNAL; PSYCHOLOGIC TEST; SCHIZOPHRENIA; SCORING SYSTEM; SYMPTOMATOLOGY;

INSERTION SEQUENCES;

EID: 1842435120     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.20135     Document Type: Article

References (42)

1. Bellivier F, Henry C, Szoke A, Schurhoff F, Nosten-Bertrand M, Feingold J, Launay JM, Leboyer M, Laplanche JL. 1998. Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression. Neurosci Lett 255(3):143-146.
2. Benjamin J, Ebstein R, Belmaker RH. 2001. Genes for human personality traits: "Endophenotypes of psychiatric disorders?" World J Biol Psychiatry 2(2):54-58.
3. Beresin FB, Miroshnikov MP, Rojanez RV. 1976. The multiple personality inventory. Moscow: Medicine. 176 p.
4. Chong SA, Lee WL, Tan CH, Tay AH, Chan AO, Tan EC. 2000. Attempted suicide and polymorphism of the serotonin transporter gene in Chinese patients with schizophrenia. Psychiatry Res 97(2-3):101-106.
5. Dollfus S, Everitt B, Ribeyre JM, Assouly-Besse F, Sharp C, Petit M. 1996. Identifying subtypes of schizophrenia by cluster analysis. Schizophr Bull 22(3):545-555.
6. El Yazaji M, Battas O, Agoub M, Moussaoui D, Gutknecht C, Dalery J, d'Amato T, Saoud M. 2002. Validity of the depressive dimension extracted from principal component analysis of the PANSS in drug-free patients with schizophrenia. Schizophr Res 56(1-2):121-127.
7. Frisch A, Postilnick D, Rockah R, Michaelovsky E, Postilnick S, Birman E, Laor N, Rauchverger B, Kreinin A, Poyurovsky M, Schneidman M, Modai I, Weizman R. 1999. Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways. Mol Psychiatry 4(4):389-392.
8. Furlong RA, Ho L, Walsh C, Rubinsztein JS, Jain S, Paykel ES, Easton DF, Rubinsztein DC. 1998. Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am J Med Genet 81(1):58-63.
9. Greenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, Lesch KP, Hamer D, Murphy DL. 2000. Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet 96(2):202-216.
10. Gutierrez B, Pintor L, Gasto C, Rosa A, Bertranpetit J, Vieta E, Fananas L. 1998. Variability in the serotonin transporter gene and increased risk for major depression with melancholia. Hum Genet 103(3):319-322.
11. Hernandez I, Sokolov BP. 1997. Abnormal expression of serotonin transpotrter mRNA in the frontal and temporal cortex of schizophrenics. Mol Psychiatry 2:57-64.
12. Joyce JN, Shane A, Lexow N, Winokur A, Casanova MF, Kleiman JE. 1993. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology 8:315-336.
13. Kaiser R, Tremblay PB, Schmider J, Henneken M, Dettling M, Muller-Oerlinghausen B, Uebelhack R, Roots I, Brockmoller J. 2001. Serotonin transporter polymorphisms: No association with response to antipsychotic treatment, but associations with the schizoparanoid and residual subtypes of schizophrenia. Mol Psychiatry 6(2):179-185.
14. Kay SR, Sevy S. 1990. Pyramidical model of schizophrenia. Schizophr Bull 16(3):537-545.
15. Kay SR, Fizbein A, Opler LA. 1987. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13:261-276.
16. Kendler KS, Neale MS, Kessler RC, Heath AC, Eaves LJ. 1993a. A longitudinal twin study of one-year prevalence of major depression in women. Arch Gen Psychiatr 50:843-852.
17. Kendler KS, Neale MS, Kessler RC, Heath AC, Eaves LJ. 1993b. The lifetime history of major depression in women: Reliability of diagnosis and heritability. Arch Gen Psychiatr 50:863-870.
18. Khanin YuL. 1978. Study of anxiety in sports. Voprosi Psichologii (Psychological Questions (in Russian)) 6:94-106.
19. Lancon C, Auquier P, Nayt G, Reine G. 2000. Stability of the five-factor structure of the Positive and Negative Syndrome Scale (PANSS). Schizophr Res 42(3):231-239.
20. Lesch KP, Mossner R. 1998. Genetically driven variation in serotonin uptake: Is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? Biol Psychiat 44:179-192.
21. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, Riederer P. 1994. Organization of human serotonin transporter gene. J Neural Transm Gen Sect 95:157-160.
22. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
23. Lesch KP, Heils A, Moessner R. 1997. Evolutionary perspective of allelic variation in 5-HT transporter expression. Am J Med Genet 74(6):620-621.
24. Lindenmayer JP, Bernstein-Hyman R, Grochowski S. 1994. A new five factor model of schizophrenia. Psychiatr Q 65(4):299-322.
25. Lykouras L, Oulis P, Psarros K, Daskalopoulou E, Botsis A, Christodoulou GN, Stefanis CF. 2000. Five-factor model of schizophrenic psychopathology: How valid is it? Eur Arch Psychiatry Clin Neurosci 250(2):93-100.
26. Malhotra AK, Goldman D, Mazzanti C, Clifton A, Breier A, Pickar D. 1998. A functional serotonin transporter (5-HTT) polymorphism is associated with psychosis in neuroleptic-free schizophrenics. Mol Psychiatry 3(4):328-332.
27. Mass R, Schoemig T, Hitschfeld K, Wall E, Haasen C. 2000. Psychopathological syndromes of schizophrenia: Evaluation of the dimensional structure of the positive and negative syndrome scale. Schizophr Bull 26(1):167-177.
28. Mendes de Oliveira JR, Otto PA, Vallada H, Lauriano V, Elkis H, Lafer B, Vasquez L, Gentil V, Passos-Bueno MR, Zatz M. 1998. Analysis of a novel functional polymorphism within the promoter region of the serotonin transporter gene (5-HTT) in Brazilian patients affected by bipolar disorder and schizophrenia. Am J Med Genet 81(3):225-227.
29. Menza MA, Palermo B, DiPaola R, Sage JI, Ricketts MHJ. 1999. Depression and anxiety in Parkinson's disease: Possible effect of genetic variation in the serotonin transporter. Geriatr Psychiatry Neurol 12(2):49-52.
30. Moreno FA, Rowe DC, Kaiser B, Chase D, Michaels T, Gelernter J, Delgado PL. 2002. Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion. Mol Psychiatry 7(2):213-216.
31. Mossner R, Henneberg A, Schmitt A, Syagailo YV, Grassle M, Hennig T, Simantov R, Gerlach M, Riederer P, Lesch KP. 2001. Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease. Mol Psychiatry 6(3):350-352.
32. Naylor L, Dean B, Opeskin K, Pavey G, Hill C, Keks N, Copolov D. 1996. Changes in serotonin transporter in the hippocampus of subjects with schizophrenia identified using (3H) paroxetine. J Neural Transm Gen Sect 103:749-757.
33. Neumeister A, Konstantinidis A, Stastny J, Schwarz MJ, Vitouch O, Willeit M, Praschak-Rieder N, Zach J, de Zwaan M, Bondy B, Ackenheil M, Kasper S. 2002. Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression. Arch Gen Psychiatry 59(7):613-620.
34. Nolan KA, Volavka J, Lachman HM, Saito T. 2000. An association between a polymorphism of the tryptophan hydroxylase gene and aggression in schizophrenia and schizoaffective disorder. Psychiatr Genet 10(3):109-115.
35. Rao D, Jonsson EG, Paus S, Ganguli R, Nothen M, Nimgaonkar VL. 1999. Schizophrenia and the serotonin transporter gene. Psychiatr Genet 9(1):51.
36. Rusalov VM. 1987. New adopted version of Eysenck Personality Inventory. J Psychol (in Russian) 8(1):113-126.
37. Serretti A, Cusin C, Lattuada E, Lilli R, Lorenzi C, Di Bella D, Catalano M, Smeraldi E. 1999. No interaction between serotonin transporter gene and dopamine receptor D4 gene in symptomatology of major psychoses. Am J Med Genet 88(5):481-485.
38. Serretti A, Lilli R, Lorenzi C, Lattuada E, Cusin C, Smeraldi E. 2002. Serotonin transporter gene (5-HTTLPR) and major psychoses. Mol Psychiatry 7(1):95-99.
39. Steffens DC, Svenson I, Marchuk DA, Levy RM, Hays JC, Flint EP, Krishnan KR, Siegler IC. 2002. Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depression. Am J Geriatr Psychiatry 10(2):185-191.
40. Stoeber G, Jatzke S, Heils A, Jungkunz G, Funchs E, Knapp M, Riederer P, Lesch KP. 1998. Susceptibility for schizophrenia is not influenced by a functional insertion/deletion variant in the promoter of the serotonin transporter gene. Eur Arch Psychiatry Clin Neurosci 248:82-86.
41. Tsai SJ, Hong CJ, Yu YW, Lin CH, Song HL, Lai HC, Yang KH. 2000. Association study of a functional serotonin transporter gene polymorphism with schizophrenia, psychopathology and clozapine response. Schizophr Res 44(3):177-181.
42. Wolthaus JE, Dingemans PM, Schene AH, Linszen DH, Knegtering H, Holthausen EA, Cahn W, Hijman R. 2000. Component structure of the positive and negative syndrome scale (PANSS) in patients with recent-onset schizophrenia and spectrum disorders. Psychopharmacology 150(4):399-403.