Allosteric Inhibition of Zinc-Finger Binding in the Major Groove of DNA by Minor-Groove Binding Ligands

Biochemistry

Volumn 43, Issue 13, 2004, Pages 3880-3890

  Nguyen Hackley, Doan H ^c   Ramm, Elizabeth ^a   Taylor, Christina M ^b   Joung, J Keith ^b   Dervan, Peter B ^c   Pabo, Carl O ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c California Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; ENZYME INHIBITION; GENES; POLYAMIDES; PROTEINS; VAN DER WAALS FORCES; ZINC;

ALLOSTERIC INHIBITION; MINOR-GROOVE BINDING LIGANDS; ZINC-FINGER BINDING;

DNA;

CYSTEINE; HISTIDINE; IMIDAZOLE DERIVATIVE; POLYAMIDE; PYRROLE DERIVATIVE; ZINC FINGER PROTEIN;

ALLOSTERISM; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DNA CONFORMATION; GENE EXPRESSION REGULATION; LIGAND BINDING; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN ENGINEERING;

ALLOSTERIC REGULATION; BASE SEQUENCE; BINDING, COMPETITIVE; COMPUTER SIMULATION; DEOXYRIBONUCLEASE I; DNA; DNA FOOTPRINTING; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FUNGAL PROTEINS; HUMANS; IMMEDIATE-EARLY PROTEINS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; NYLONS; PROTEIN BINDING; TATA-BOX BINDING PROTEIN; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; ZINC FINGERS;

EID: 1842434977     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi030223c     Document Type: Article

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