Increased iron staining in the cerebral cortex of cholesterol fed rabbits

Mechanisms of Ageing and Development

Volumn 125, Issue 4, 2004, Pages 305-313

  Ong, Wei Yi ^a   Tan, Benny ^a   Pan, Ning ^a   Jenner, Andrew ^a   Whiteman, Matthew ^a   Ong, Choon Nam ^a   Watt, Frank ^a   Halliwell, Barry ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Atherosclerosis; Brain; Cholesterol; Hypercholesterolemia; Iron; Oligodendrocytes

Indexed keywords

BILIRUBIN; HEME OXYGENASE 1; IRON;

ANIMAL MODEL; ANIMAL TISSUE; BRAIN CELL; BRAIN CORTEX; CHOLESTEROL DIET; CONFERENCE PAPER; CONTROLLED STUDY; ENDOTHELIUM CELL; HYPERCHOLESTEROLEMIA; IMMUNOREACTIVITY; IRON TRANSPORT; LIPID BLOOD LEVEL; LIPID PEROXIDATION; NERVE CELL LESION; NERVE CELL NECROSIS; NONHUMAN; OLIGODENDROGLIA; PARENCHYMA; PRIORITY JOURNAL; RABBIT; STAINING;

ANIMALS; BILIRUBIN; CELL DEATH; CEREBRAL CORTEX; CHOLESTEROL, DIETARY; FILIPIN; FLUORESCENT DYES; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HISTOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAMUSCULAR; IRON; IRON-DEXTRAN COMPLEX; MICROSCOPY, ELECTRON; NEURONS; ORGANIC CHEMICALS; RABBITS; STAINING AND LABELING;

ORYCTOLAGUS CUNICULUS;

EID: 1842421166     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2004.01.008     Document Type: Conference Paper

References (43)

1. Aydemir E.O., Duman C., Celik H.A., Turgan N., Uysal A., Mutaf I., Habif S., Ozmen D., Nisli N., Bayindir O. Effects of defibrotide on aorta and brain malondialdehyde and antioxidants in cholesterol-induced atherosclerotic rabbits. Int. J. Clin. Lab. Res. 30:2000;101-107.
2. Basu M.K., Flamm M., Schachter D., Bertles J.F., Maniatis A. Effects of modulating erythrocyte membrane cholesterol on Rho (D) antigen expression. Biochem. Biophys. Res. Commun. 95:1980;887-893.
3. Bodovitz S., Klein W.L. Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein. J. Biol. Chem. 271:1996;4436-4440.
4. Bush A.I. Metal complexing agents as therapies for Alzheimer's disease. Neurobiol. Aging. 23:2002;1031-1038.
5. Chirico S., Smith C., Marchant C., Mitchinson M.J., Halliwell B. Lipid peroxidation in hyperlipidaemic patients. A study of plasma using an HPLC-based thiobarbituric acid test. Free Rad. Res. Commun. 19:1993;51-57.
6. Connor J.R., Pavlick G., Karli D., Menzies S.L., Palmer C. A histochemical study of iron-positive cells in the developing rat brain. J. Comp. Neurol. 355:1995;111-123.
7. Connor J.R., Menzies S.L., St Martin S.M., Mufson E.J. Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains. J. Neurosci. Res. 27:1990;595-611.
8. De Caterina R., Cipollone F., Filardo F.P., Zimarino M., Bernini W., Lazzerini G., Bucciarelli T., Falco A., Marchesani P., Muraro R., Mezzetti A., Ciabattoni G. Low-density lipoprotein level reduction by the 3-hydroxy-3-methylglutaryl coenzyme-A inhibitor simvastatin is accompanied by a related reduction of F2-isoprostane formation in hypercholesterolemic subjects: no further effect of Vitamin E. Circulation. 106:2002;1543-2549.
9. De La Cruz J.P., Quintero L., Galvez J., Villalobos M.A., Sanchez de la Cuesta F. Antioxidant potential of evening primrose oil administration in hyperlipemic rabbits. Life Sci. 65:1999;543-555.
10. De La Cruz J.P., Quintero L., Villalobos M.A., Sanchez de la Cuesta F. Lipid peroxidation and glutathione system in hyperlipemic rabbits: influence of olive oil administration. Biochim. Biophys. Acta. 1485:2000;36-44.
11. Dietschy J.M., Turley S.D. Cholesterol metabolism in the brain. Curr. Opin. Lipidol. 12:2001;105-112.
12. Fan Q.W., Yu W., Senda T., Yanagisawa K., Michikawa M. Cholesterol-dependent modulation of tau phosphorylation in cultured neurons. J. Neurochem. 76:2001;391-400.
13. Fassbender K., Simons M., Bergmann C., Stroick M., Lutjohann D., Keller P., Runz H.M., Kuhl S., Bertsch T., von Bergmann K., Hennerici M., Beyreuther K., Hartmann T. Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta42 and Abeta40 in vitro and in vivo. Proc. Natl. Acad. Sci. U.S.A. 98:2001;5856-5861.
14. Heron D.S., Shinitzky M., Hershkowitz M., Samuel D. Lipid fluidity markedly modulates the binding of serotonin to mouse brain membranes. Proc. Natl. Acad. Sci. U.S.A. 77:1980;7463-7467.
15. Hill J.M., Switzer R.C. Jr. The regional distribution and cellular localization of iron in the rat brain. Neuroscience. 11:1984;595-603.
16. Howland D.S., Trusko S.P., Savage M.J., Reaume A.G., Lang D.M., Hirsch J.D., Maeda N., Siman R., Grenberg B.D., Scott R.W., Flood D.G. Modulation of secreted beta-amyloid precursor protein and amyloid β-peptide in brain by cholesterol. J. Biol. Chem. 273:1998;16576-16582.
17. Izumi Y., Yamazaki M., Shimizu S., Shimizu K., Yamaguchi T., Nakajima H. Anti-bilirubin monoclonal antibody. Part II. Enzyme-linked immunosorbent assay for bilirubin fractions by combination of two monoclonal antibodies. Biochim. Biophys. Acta. 967:1988;261-266.
18. Jick H., Zornberg G.L., Jick S.S., Seshadri S., Drachman D.A. Statins and the risk of dementia. Lancet. 356:2000;1627-1631.
19. Kalmijn S., Launer L.J., Ott A., Witteman J.C., Hofman A., Breteler M.M. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann. Neurol. 42:1997;776-782.
20. Lubrano V., Vassalle C., Blandizzi C., Del Tacca M., Palombo C., L'Abbate A., Baldi S., Natali A. The effect of lipoproteins on endothelial nitric oxide synthase is modulated by lipoperoxides. Eur. J. Clin. Invest. 33:2003;117-125.
21. Maines M.D. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J. 2:1988;2557-2568.
22. Matsuo M., Ito F., Konto A., Aketa M., Tomoi M., Shimomura K. Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits. Evidence for a direct effect on the arterial wall. Biochim. Biophys. Acta. 1259:1995;254-260.
23. McManus, J.F.A., Mowry, R.W., 1960. Staining methods for iron. In: McManus, J.F.A., Mowry, R.W. (Eds.), Staining Methods - Histologic and Histochemical. Paul B. Hoeber, New York, pp. 195-197.
24. Nakayama M., Takahashi K., Komaru T., Fukuchi M., Shioiri H., Sato Ki., Kitamuro T., Shirato K., Yamaguchi T., Suematsu M., Shibahara S. Increased expression of heme oxygenase-1 and bilirubin accumulation in foam cells of rabbit atherosclerotic lesions. Arterioscler. Thromb. Vasc. Biol. 21:2001;1373-1377.
25. Nguyen-Legros J., Bizot J., Bolesse M., Pulicani J.P. Diaminobenzidine black as a new histochemical demonstration of exogenous iron. Histochemistry. 66:1980;239-244.
26. Ong W.Y., Ren M.Q., Makjanic J., Lim T.M., Watt F. A nuclear microscopic study of elemental changes in the rat hippocampus after kainate-induced neuronal injury. J. Neurochem. 72:1999;1574-1579.
27. Ong W.Y., Goh E.W.S., Lu X.R., Farooqui A.A., Patel S.C., Halliwell B. Increase in cholesterol and cholesterol oxidation products, and role of cholesterol oxidation products in kainate-induced neuronal injury. Brain Pathol. 13:2003;250-262.
28. Peters, A., Palay, S.L., Webster, H., de F., 1991. The Fine Structure of the Nervous System. Neurons and Their Supporting Cells, third ed. Oxford University Press, New York, Oxford.
29. Papahadjopoulos D., Cowden M., Kimelberg H. Role of cholesterol in membranes. Effects on phospholipid-protein interactions, membrane permeability and enzymatic activity. Biochim. Biophys. Acta. 330:1973;8-26.
30. Patterson, M.C., Vanier, M.T., Suzuki, K., Morris, J.A., Carstea, E.D., Neufeld, E.B., Blancette-Mackie, E.J., Pentchev, P.G., 2001. Niemann-Pick disease type C: a lipid tracking disorder. In: Scriver, C., Beaudet, A., Sly, W., Vale, D., (Eds.), The Metabolic and Molecular Bases of Inherited Disease. McGraw Hill, New York, pp. 3611-3634.
31. Refolo L.M., Malester B., LaFrancois J., Bryant-Thomas T., Wang R., Tint G.S., Sambamurti K., Duff K., Pappolla M.A. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol. Dis. 7:2000;321-331.
32. Roher A.E., Kuo Y.M., Kokjohn K.M., Emmerling M.R., Gracon S. Amyloid and lipids in the pathology of Alzheimer disease. Amyloid. 6:1999;136-145.
33. Schmued L.C., Albertson C., Slikker W. Jr. Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res. 751:1997;37-46.
34. Simons M., Keller P., De Strooper B., Beyreuther K., Dotti C., Simons K. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc. Natl. Acad. Sci. U.S.A. 95:1998;6460-6464.
35. Sparks D.L., Scheff S.W., Hunsaker J.C. Jr., Liu H., Landers T., Gross D.R. Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol. Exp. Neurol. 126:1994;88-94.
36. Turley S.D., Burns D.K., Rosenfeld C.R., Dietschy J.M. Brain does not utilize low density lipoprotein-cholesterol during fetal and neonatal development in the sheep. J. Lipid Res. 37:1996;1953-1961.
37. Vaughan C.J., Delanty N. Neuroprotective properties of statins in cerebral ischemia and stroke. Stroke. 30:1999;1969-1973.
38. Vega, G.L., Weiner, M.F., Lipton, A.M., Von Bergmann, K., Lutjohann, D., Moore, C., Svetlik, D., 2003. Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer's disease. Arch. Neurol. 60, 510-515.
39. Walker L.N., Reidy M.A., Bowyer D.E. Morphology and cell kinetics of fatty streak lesion formation in the hypercholesterolemic rabbit. Am. J. Pathol. 125:1986;450-459.
40. Wang X.S., Ong W.Y., Connor J.R. Increase in ferric and ferrous iron in the rat hippocampus with time after kainate-induced excitotoxic injury. Exp. Brain. Res. 143:2002;137-148.
41. Wolozin B., Kellman W., Ruosseau P., Celesia G.G., Siegel G. Decreased prevalence of Alzheimer's disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch. Neurol. 57:2000;1439-1443.
42. Youssef S., Stuve O., Patarroyo J.C., Ruiz P.J., Radosevich J.L., Hur E.M., Bravo M., Mitchell D.J., Sobel R.A., Steinman L., Zamvil S.S. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature. 420:2002;78-84.
43. Zhang H.F., Ong W.Y., Leong S.K., Garey L.J. Ultrastructural characteristics of blood vessels in the infant and adult human cerebral cortex. Histol. Histopathol. 12:1997;85-97.