Increased expression of heme oxygenase-1 and bilirubin accumulation in foam cells of rabbit atherosclerotic lesions

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 21, Issue 8, 2001, Pages 1373-1377

  Nakayama, Masaharu ^a   Takahashi, Kazuhiro ^a   Komaru, Tatsuya ^a   Fukuchi, Mitsumasa ^a   Shioiri, Hiroki ^a   Sato, Ko Ichi ^a   Kitamuro, Tomomi ^a   Shirato, Kunio ^a   Yamaguchi, Tokio ^b   Suematsu, Makoto ^c   Shibahara, Shigeki ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c KEIO UNIVERSITY   (Japan)

Author keywords

Atherosclerosis; Bilirubin IX ; Cholesterol; Foam cells; Heme oxygenase 1

Indexed keywords

BILIRUBIN; BILIVERDIN; CARBON MONOXIDE; HEME; HEME OXYGENASE 1; IRON; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 24G7; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL DIET; CONTROLLED STUDY; ENDOTHELIUM CELL; FOAM CELL; HYPERCHOLESTEROLEMIA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MACROPHAGE ACTIVATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RABBIT;

EID: 0035574676     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/hq0801.093592     Document Type: Article

References (41)

1. The pathogenesis of atherosclerosis: A perspective for 1990s
2. Low density lipoprotein oxidation and its pathological significance
3. Oxidized LDL induces transcription factor activator protein-1 but inhibits activation of nuclear factor-B in human vascular smooth muscle cells
4. LDL induces transcription factor activator protein-1 in human endothelial cells
5. Probucol and multivitamins in the prevention of restenosis after coronary angioplasty: Multivitamins and Probucol Study Group
6. Vitamin C improves endothelium-dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia
7. Increased levels of soluble P-selectin in hypercholesterolemic patients
8. Features of the reaction of heme degradation catalyzed by the reconstituted microsomal heme oxygenase system
9. Bilirubin is an antioxidant of possible physiological importance
10. Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation
11. Bilirubin is oxidized in rats treated with endotoxin and acts as a physiological antioxidant synergistically with ascorbic acid in vivo
12. Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL
13. Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: Role of bilirubin generated by the enzyme
14. Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase
15. Carbon monoxide: A putative neuronal messenger
16. Carbon monoxide: An endogenous modulator of sinusoidal tone in the perfused rat liver
17. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP
18. Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity
19. Cloning and expression of cDNA for rat heme oxygenase
20. Expression of heme oxygenase isozyme mRNA in the human brain and induction of heme oxgenase-1 by nitric oxide donors
21. Regulation of heme oxygenase-1 expression in vivo and in vitro in hyperoxic lung injury
22. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblast by UVA radiation, hydrogen peroxide, and sodium arsenite
23. Human heme oxygenase eDNA and induction of its mRNA by hemin
24. Heme oxygenase 1 is required for mammalian iron reutilization
25. Reduced stress defense in heme oxygenase 1-deficient cells
26. Heme oxygenase 1 is required for mammalian iron reutilization
27. Expression of heme oxygenase-1 in atherosclerotic lesions
28. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury
29. Heterogeneous expression and activity of endothelial and inducible nitric oxide synthases in end-stage human heart failure: Their relation to lesion site and β-adrenergic receptor therapy
30. Distribution of heme oxygenase isoforms in rat liver: Topographic basis for carbon monoxide-mediated microvascular relaxation
31. Anti-bilirubin monoclonal antibody, II: Enzyme-linked immunosorbent assay for bilirubin fractions by combination of two monoclonal antibodies
32. Epitope of 24G7 anti-bilirubin monoclonal antibody
33. Induction of stress proteins in mouse peritoneal macrophages by oxidized low-density lipoprotein
34. Induction of the antioxidant stress proteins heme oxygenase-1 and MSP23 by stress agents and oxidised LDL in cultured vascular smooth muscle cells
35. Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice
36. Linoleyl hydroperoxide transcriptionally upregulates heme oxygenase-1 gene expression in human renal epithelial and aortic endothelial cells
37. Expression of heme oxygenase-1 (HSP32) in human prostate: Normal, hyperplastic, and tumor tissue distribution
38. Mechanism of increase of heme oxygenase activity induced by hemin in cultured pig alveolar macrophages
39. Evidence suggesting that the two forms of heme oxygenase are products of different genes
40. Influence of glutathione S-transferase B (ligandin) on the intermembrane transfer of bilirubin: Implications for the intracellular transport of nonsubstrate ligands in hepatocytes
41. Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease