Cell-growth control by monomeric antigen: The cell surface expression of lysozyme-specific Ig V-domains fused to truncated Epo receptor

Journal of Immunological Methods

Volumn 241, Issue 1-2, 2000, Pages 159-170

  Ueda, Hiroshi ^a,e   Kawahara, Masahiro ^a   Aburatani, Takahide ^a   Tsumoto, Kouhei ^b   Todokoro, Kazuo ^c   Suzuki, Eiji ^a   Nishimura, Hajime ^a   Schueler, Paula A ^d   Winter, Greg ^e   Mahoney, Walt C ^d   Kumagai, Izumi ^b   Nagamune, Teruyuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c RIKEN TSUKUBA INSTITUTE   (Japan)

^d Roche Diagnostics   (United States)

^e MRC CENTRE FOR PROTEIN ENGINEERING   (United Kingdom)

Author keywords

Antibody variable region; Fusion protein; Growth control; Protein engineering; Receptor dimerization

Indexed keywords

ANTIBODY; ERYTHROPOIETIN RECEPTOR; HYBRID PROTEIN; INTERLEUKIN 3; RECOMBINANT PROTEIN;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL CULTURE; CELL GROWTH; CELL LINE; CELL SURFACE; CONTROLLED STUDY; GENE TRANSFER; IN VITRO STUDY; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN DOMAIN;

CELL MEMBRANE; DNA-BINDING PROTEINS; GROWTH SUBSTANCES; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; LIGANDS; MILK PROTEINS; MURAMIDASE; PHOSPHORYLATION; PROTEIN ENGINEERING; RECEPTORS, ERYTHROPOIETIN; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

MURINAE;

EID: 18244428404     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(00)00202-7     Document Type: Article

References (47)

1. Blau C.A., Peterson K.R., Drachman J.G., Spencer D.M. A proliferation switch for genetically modified cells. Proc. Natl. Acad. Sci. USA. 94:1997;3076.
2. Chiba T., Nagata Y., Machide M., Kishi A., Amanuma H., Sugiyama M., Todokoro K. Tyrosine kinase activation through the extracellular domains of cytokine receptors. Nature. 362:1993;646.
3. Cwirla S.E., Balasubramanian P., Duffin D.J., Wagstrom C.R., Gates C.M., Singer S.C., Davis A.M., Tansik R.L., Mattheakis L.C., Boytos C.M., Schatz P.J., Baccanari D.P., Wrighton N.C., Barrett R.W., Dower W.J. Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine. Science. 276:1997;1696.
4. D'Andrea A.D., Lodish H.F., Wong G.G. Expression cloning of the murine erythropoietin receptor. Cell. 57:1989;277.
5. Darcy P.K., Kershaw M.H., Trapani J.A., Smyth M.J. Expression in cytotoxic T lymphocytes of a single-chain anti-carcinoembryonic antigen antibody. Redirected Fas ligand-mediated lysis of colon carcinoma. Eur. J. Immunol. 28:1998;1663.
6. Deutsch H.H., Koettnitz K., Chung J., Kalthoff F.S. Distinct sequence motifs within the cytoplasmic domain of the human IL-4 receptor differentially regulate apoptosis inhibition and cell growth. J. Immunol. 154:1995;3696.
7. Fuh G., Cunningham B.C., Fukunaga R., Nagata S., Goeddel D.V., Wells J.A. Rational design of potent antagonists to the human growth hormone receptor. Science. 256:1992;1677.
8. Glockshuber R., Malia M., Pfitzinger I., Plückthun A. A comparison of strategies to stabilize immunoglobulin Fv-fragments. Biochemistry. 29:1990;1362.
9. Goverman J., Gomez S.M., Segesman K.D., Hunkapiller T., Laug W.E., Hood L. Chimeric immunoglobulin-T cell receptor proteins form functional receptors: implications for T cell receptor complex formation and activation. Cell. 60:1990;929.
10. Greenberger J.S., Sakakeeny M.A., Humphries R.K., Eaves C.J., Eckner R.J. Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. Proc. Natl. Acad. Sci. USA. 80:1983;2931.
11. Gross G., Waks T., Eshhar Z. Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc. Natl. Acad. Sci. USA. 86:1989;10024.
12. Hedrick S.M. Chimeric T cell receptor-immunoglobulin molecules: function and applications. Int. Rev. Immunol. 10:1993;279.
13. Hombach A., Heuser C., Sircar R., Tillmann T., Diehl V., Kruis W., Pohl C., Abken H. T cell targeting of TAG72+ tumor cells by a chimeric receptor with antibody-like specificity for a carbohydrate epitope. Gastroenterology. 113:1997;1163.
14. Hwu P., Yang J.C., Cowherd R., Treisman J., Shafer G.E., Eshhar Z., Rosenberg S.A. In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes. Cancer Res. 55:1995;3369.
15. Ihle J.N., Witthuhn B.A., Quelle F.W., Yamamoto K., Thierfelder W.E., Kreider B., Silvennoinen O. Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends Biochem. Sci. 19:1994;222.
16. Jones S.S., D'Andrea A.D., Haines L.L., Wong G.G. Human erythropoietin receptor: cloning, expression, and biologic characterization. Blood. 76:1990;31.
17. Kabat E.A., Wu T.T., Perry H.M., Gottesman K.S., Foeller C. Sequences of Proteins of Immunological Interest. 5th Edition :1991;National Institutes of Health Public Health Service, Bethesda, MD.
18. Kirby S.L., Cook D.N., Walton W., Smithies O. Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene. Proc. Natl. Acad. Sci. USA. 93:1996;9402.
19. Kuramochi S., Ikawa Y., Todokoro K. Characterization of murine erythropoietin receptor genes. J. Mol. Biol. 216:1990;567.
20. Kuwana Y., Asakura Y., Utsunomiya N., Nakanishi M., Arata Y., Itoh S., Nagase F., Kurosawa Y. Expression of chimeric receptor composed of immunoglobulin-derived V regions and T-cell receptor-derived C regions. Biochem. Biophys. Res. Commun. 149:1987;960.
21. Leaman D.W., Leung S., Li X., Stark G.R. Regulation of STAT-dependent pathways by growth factors and cytokines. Faseb J. 10:1996;1578.
22. Li J., D'Aandrea A.D., Lodish H.F., Baltimore D. Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor. Nature. 343:1990;762.
23. Livnah O., Johnson D.L., Stura E.A., Farrell F.X., Barbone F.P., You Y., Liu K.D., Goldsmith M.A., He W., Krause C.D., Jolliffe S.P.L.K., Wilson I.A. An antagonist peptide; EPO receptor complex suggests that receptor dimerization is not sufficient for activation. Nature Struct. Biol. 5:1998;993.
24. Livnah O., Stura E.A., Johnson D.L., Middleton S.A., Mulcahy L.S., Wrighton N.C., Dower W.J., Jolliffe L.K., Wilson I.A. Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8 Å Science. 273:1996;464.
25. Maeda H., Steffen E., Engel J. Kinetics of dimerization of the Bence-Jones protein AU. Biophys. Chem. 9:1978;57.
26. Makishima F., Terada S., Mikami T., Suzuki E. Interleukin-6 is antiproliferative to a mouse hybridoma cell line and promotive for its antibody productivity. Cytotechnology. 10:1992;15.
27. Palacios R., Steinmetz M. Il-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo. Cell. 41:1985;727.
28. Rui H., Lebrun J.J., Kirken R.A., Kelly P.A., Farrar W.L. JAK2 activation and cell proliferation induced by antibody-mediated prolactin receptor dimerization. Endocrinology. 135:1994;1299.
29. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning, A Laboratory Manual. second edition :1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
30. Schlessinger J. Signal transduction by allosteric receptor oligomerization. Trends Biochem. Sci. 13:1988;443.
31. Schneider H., Chaovapong W., Matthews D.J., Karkaria C., Cass R.T., Zhan H., Boyle M., Lorenzini T., Elliott S.G., Giebel L.B. Homodimerization of erythropoietin receptor by a bivalent monoclonal antibody triggers cell proliferation and differentiation of erythroid precursors. Blood. 89:1997;473.
32. Spencer D.M., Wandless T.J., Schreiber S.L., Crabtree G.R. Controlling signal transduction with synthetic ligands. Science. 262:1993;1019.
33. Stevens F.J., Westholm F.A., Solomon A., Schiffer M. Self-association of human immunoglobulin κI light chains: Role of the third hypervariable region. Proc. Natl. Acad. Sci. USA. 77:1980;1144.
34. L- alkaline phosphatase fusion proteins. J. Immunol. Methods. 224:1999;171.
35. Suzuki E., Ollis D.F. Enhanced antibody production at slowed growth rates: experimental demonstration and a simple structured model. Biotechnol. Prog. 6:1990;231.
36. Syed R.S., Reid S.W., Li C., Cheetham J.C., Aoki K.H., Liu B., Zhan H., Osslund T.D., Chirino A.J., Zhang J., Finer-Moore J., Elliott S., Sitney K., Katz B.A., Matthews D.J., Wendoloski J.J., Egrie J., Stroud R.M. Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature. 395:1998;511.
37. Terada S., Suzuki E., Ueda H., Makishima F. Cytokines involving gp130 in signal transduction suppressed growth of a mouse hybridoma cell line and enhanced its antibody production. Cytokine. 8:1996;889.
38. Tsumoto K., Nishimiya Y., Kasai N., Ueda H., Nagamune T., Ogasahara K., Yutani K., Tokuhisa K., Matsushima M., Kumagai I. Novel selection method for engineered antibodies using the mechanism of Fv fragment stabilization in the presence of antigen. Protein Eng. 10:1997;1311.
39. Tsumoto K., Ueda Y., Maenaka K., Watanabe K., Ogasawara K., Yutani K., Kumagai I. Contribution to antibody-antigen interaction of structurally perturbed antigenic residues upon antibody binding. J. Biol. Chem. 269:1994;28777.
40. Ueda H., Kikuchi M., Yagi S., Nishimura H. Antigen responsive antibody-receptor kinase chimera. Bio/Technology. 10:1992;430.
41. Ueda H., Tsumoto K., Kubota K., Suzuki E., Nagamune T., Nishimura H., Schueler P.A., Winter G., Kumagai I., Mahoney W.C. Open sandwich ELISA: A novel immunoassay based on the interchain interaction of antibody variable region. Nature Biotechnol. 14:1996;1714.
42. Ueda Y., Tsumoto K., Watanabe K., Kumagai I. Synthesis and expression of a DNA encoding the Fv domain of an anti-lysozyme monoclonal antibody, HyHEL10, in Streptomyces lividans. Gene. 129:1993;129.
43. Wang G., Chopra R.K., Royal R.E., Yang J.C., Rosenberg S.A., Hwu P. A T cell-independent antitumor response in mice with bone marrow cells retrovirally transduced with an antibody/Fc-gamma chain chimeric receptor gene recognizing a human ovarian cancer antigen. Nature Med. 4:1998;168.
44. Watanabe S., Arai K. Roles of the JAK-STAT system in signal transduction via cytokine receptors. Curr. Opin. Genet. Dev. 6:1996;587.
45. Watowich S.S., Hilton D.J., Lodish H.F. Activation and inhibition of erythropoietin receptor function: Role of receptor dimerization. Mol. Cell. Biol. 14:1994;3535.
46. Weijtens M.E., Willemsen R.A., van Krimpen B.A., Bolhuis R.L. Chimeric scFv/gamma receptor-mediated T-cell lysis of tumor cells is coregulated by adhesion and accessory molecules. Int. J. Cancer. 77:1998;181.
47. Wrighton N.C., Farrell F.X., Chang R., Kashyap A.K., Barbone F.P., Mulcahy L.S., Johnson D.L., Barrett R.W., Jolliffe L.K., Dower W.J. Small peptides as potent mimetics of the protein hormone erythropoietin. Science. 273:1996;458.