Novel selection method for engineered antibodies using the mechanism of Fv fragment stabilization in the presence of antigen

Protein Engineering

Volumn 10, Issue 11, 1997, Pages 1311-1318

  Tsumoto, Kouhei ^a   Nishimiya, Yoshiyuki ^a   Kasai, Nobuhiro ^a   Ueda, Hiroshi ^b   Nagamune, Teruyuki ^b   Ogasahara, Kyoko ^c   Yutani, Katsuhide ^c   Tokuhisa, Kenji ^d   Matsushima, Masaaki ^d   Kumagai, Izumi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d Rational Drug Design Laboratories   (Japan)

Author keywords

Antibody engineering; Complementarity determining regions; Fv fragment; Isothermal titration calorimetry; Phage display

Indexed keywords

ANTIBODY; LYSOZYME; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY REACTION; ARTICLE; BACTERIOPHAGE; BINDING AFFINITY; CALORIMETRY; CONTROLLED STUDY; DNA SEQUENCE; ENTROPY; ENZYME ACTIVITY; ESCHERICHIA COLI; GENETIC ENGINEERING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STABILITY; THERMODYNAMICS;

ESCHERICHIA COLI; FILAMENTOUS BACTERIOPHAGE;

EID: 15644380223     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/10.11.1311     Document Type: Article

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