A T cell-independent antitumor response in mice with bone marrow cells retrovirally transduced with an antibody/Fc-γ chain chimetic receptor gene recognizing a human ovarian cancer antigen

Nature Medicine

Volumn 4, Issue 2, 1998, Pages 168-172

  Wang, Gang ^a   Chopra, Rajesh K ^a,b   Royal, Richard E ^a   Yang, James C ^a   Rosenberg, Steven A ^a   Hwu, Patrick ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b OSIRIS THERAPEUTICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; TUMOR ANTIGEN;

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW CELL; CELL SURFACE; CONTROLLED STUDY; GENETIC TRANSDUCTION; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR REJECTION;

ANIMALS; ANTIBODIES, MONOCLONAL; CYTOKINES; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOTHERAPY; MICE; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; OVARIAN NEOPLASMS; RADIATION DOSAGE; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS; RETROVIRIDAE; T-LYMPHOCYTES;

EID: 0031907055     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0298-168     Document Type: Article

References (30)

1. Rosenberg, S.A. Immunotherapy and gene therapy of cancer. Cancer Res. (Suppl.) 51, 50745-50795 (1991).
2. Rosenberg, S.A. Gene therapy for cancer. JAMA 268, 2416-2419 (1992).
3. Rosenberg, S.A. et al. Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2. J. Natl. Cancer Inst. 86, 1159-1161 (1994).
4. Eshhar, Z. & Gross, G. Chimeric T cell receptor which incorporates the anti-tumor specificity of a monoclonal antibody with the cytolytic activity of T cells: A model system for immunotherapeutical approach. Br. J. Cancer 62 (Suppl. 10), 27-29(1990).
5. Gross, G. & Eshhar, Z. Endowing T cells with antibody specificity using chimeric T cell receptors. FASEB J. 6, 3370-3378 (1992).
6. Hwu, P. et al. Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain. J. Exp. Med. 178, 361-366 (1993).
7. Eshhar, Z., Waks, T., Gross, G. & Schindler, D.G. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the γ or ζ subunits of the immunoglobulin and T-cell receptors. Proc. Natl. Acad. Sci. USA 90, 720-724 (1993).
8. Hwu, P. et al. In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes. Cancer Res. 55, 3369-3373 (1995).
9. Royal, R.E., Daly, T., Rosenberg, S.A. & Hwu, P. Specific immune recognition of gastrointestinal cancer by lymphocytes expressing a chimeric T-cell receptor. Proc. Am. Assoc. Cancer Res. 37, 481 (1996).
10. + T lymphocytes armed with universal T-cell receptors. Blood 84, 2878-2889 (1994).
11. Walker, R.E. et al. A phase I/II pilot study of the safety of the adoptive transfer of syngeneic gene-modified cytotoxic T lymphocytes in HIV-infected identical twins. Hum. Gene Ther. 7, 367-400 (1996).
12. Tran, A-C., Zhang, D., Byrn, R. & Roberts, M.R. Chimeric ζ-receptors direct human natural killer (NK) effector function to permit killing of NK-resistant tumor cells and HIV-infected T lymphocytes. J. Immunol. 155, 1000-1009 (1995).
13. Moritz, D., Wels, W., Mattern, J. & Broner, B. Cytotoxic T lymphocytes with a grafted recognition specificity for ErbB2-expressing tumor cells. Proc. Natl. Acad. Sci. USA 91, 4318-4322 (1994).
14. Wels, W. et al. Biotechnological and gene therapeutic strategies in cancer treatment. Cene 159, 73-80 (1995).
15. Orloff, D.G., Ra, C.S., Frank, S.J., Klausner, R.D. & Kinet, J.R. Family of disulphide-linked dimers containing the zeta and eta chains of the T-cell receptor and the gamma chain of Fc receptor. Nature 347, 189-191 (1990).
16. Miotti, S. et al. Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificity. Int. J. Cancer 39, 297-303 (1987).
17. Coney, L.R. et al. Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein. Cancer Res. 51, 6125-6132 (1991).
18. Shiloni, E. et al. Retroviral transduction of interferon-gamma cDNA into a nonimmunogenic murine fibrosarcoma: Generation of T cells in draining lymph nodes capable of treating established parental metastatic tumor. Cancer Immunol. Immunother. 37, 286-292 (1993).
19. Karp, S.E. et al. Cytokine secretion by genetically modified nonimmunogenic murine fibrosarcoma. Tumor inhibition by IL-2 but not tumor necrosis factor. J. Immunol. 150, 896-908 (1993).
20. Palmer, T.D., Rosman, G.J., Osborne, W.R.A. & Miller, A.D. Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes. Proc. Natl. Acad. Sci. USA 88, 1330-1334 (1991).
21. Brocker, T. & Karjalainen, K. Signals through T cell receptor γ chain alone are insufficient to prime resting T lymphocytes. J. Exp. Med. 181, 1653-1659 (1995).
22. Pardoll, D.M. et. al. Thymus-dependent and thymus-independent developmental pathways for peripheral T cell receptor-bearing lymphocytes. J. Immunol. 140, 4091-4096 (1988).
23. Miller, A.D. & Rosman, G.J. Improved retroviral vectors for gene transfer and expression. Biotechniques 7, 980-982, 984-986, 989-990 (1989).
24. Hoatlin, M.E., Kozak, S.L., Spiro, C. & Kabat, D. Amplified and tissue-directed expression of retroviral vectors using ping-pong techniques. J. Mol. Med. 73, 113-120 (1995).
25. Bodine, D.M., Karlsson, S. & Neinhuis, A.W. Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 86, 8897-8901 (1989).
26. Orlic, D. & Bodine, D.M. What defines a pluripotent hematopoietic stem cell (PHSC): Will the real PHSC please stand up! Blood 84, 3991-3994 (1994).
27. Jordan, C.T. & Lemischka, I.R. Clonal and systemic analysis of long-term hematopoiesis in the mouse. Genes Dev. 4, 220-232 (1990).
28. Sorrentino, B.P. et al. Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1. Science 257, 99-103 (1992).
29. Sykes, M. et al. Specific prolongation of skin graft survival following retroviral transduction of bone marrow with an allogeneic major histocompatibility complex gene. Transplantation 55, 197-202 (1993).
30. Kruisbeek, A.M. In vivo depletion of CD4- and CDS-specific T cells. in Current Protocols in Immunology, (eds. Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. & Strober, W.) 4.1.1-4.1.5 (Wiley and Sons, New York, 1991).