Multiple 5′-splice variants of the rat glutamate transporter-1

Molecular Brain Research

Volumn 133, Issue 1, 2005, Pages 157-161

  Rozyczka, Joanna ^a   Engele, Jürgen ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Alternative splicing; Astrocytes; Cerebellum; Cortex; Glutamate transporters; Mesencephalon; Spinal cord

Indexed keywords

GLUTAMATE TRANSPORTER; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; MESSENGER RNA;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN VARIANT; RAT; ALTERNATIVE RNA SPLICING; ANIMAL; CENTRAL NERVOUS SYSTEM; COMPARATIVE STUDY; EXON; GENE EXPRESSION; GENETIC VARIABILITY; GENETICS; HISTOLOGY; METABOLISM; METHODOLOGY; NORTHERN BLOTTING; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING;

ALTERNATIVE SPLICING; ANIMALS; BLOTTING, NORTHERN; CENTRAL NERVOUS SYSTEM; EXCITATORY AMINO ACID TRANSPORTER 2; EXONS; GENE EXPRESSION; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA SPLICE SITES; RNA, MESSENGER; VARIATION (GENETICS);

EID: 18244407070     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2004.09.021     Document Type: Article

References (31)

1. E. Aronica, J.A. Gorter, H. Ijlst-Keizers, A.J. Rozemuller, B. Yankaya, S. Leenstra, and D. Troost Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins Eur. J. Neurosci. 17 2003 2106 2118
2. W. Chen, V. Mahadomrongkul, U.V. Berger, M. Bassan, T. DeSilva, K. Tanaka, N. Irwin, C. Aoki, and P.A. Rosenberg The glutamate transporter GLT1a is expressed in excitatory axon terminals of mature hippocampal neurons J. Neurosci. 24 2004 1136 1148
3. M. Figiel, and J. Engele Pituitary adenylate cyclase-activating polypetide (PACAP), a neuron-derived peptide regulating glial glutamate transport and metabolism J. Neurosci. 15 2000 3596 3605
4. M. Figiel, T. Maucher, J. Rozyczka, N. Bayatti, and J. Engele Regulation of glial glutamate transporter expression by growth factors Exp. Neurol. 183 2003 124 135
5. J.M. Flowers, J.F. Powell, P.N. Leigh, P. Andersen, and C.E. Shaw Intron 7 retention and exon 9 skipping EAAT2 mRNA variants are not associated with amyotrophic lateral sclerosis Ann. Neurol. 49 2001 643 649
6. A. Furuta, J.D. Rothstein, and L.J. Martin Glutamate transporter protein subtypes are expressed differentially during rat CNS development J. Neurosci. 17 1997 8363 8375
7. G. Gegelashvili, M.B. Robinson, D. Trotti, and T. Rauen Regulation of glutamate transporters in health and disease Prog. Brain Res. 132 2001 267 286
8. L.S. Honig, D.D. Chambliss, E.H. Bigio, S.L. Carroll, and J.L. Elliott Glutamate transporter EAAT2 splice variants occur not only in ALS, but also in AD and controls Neurology 55 2000 1082 1088
9. A. Kalandadze, Y. Wu, and M.B. Robinson Protein kinase C activation decreases cell surface expression of the GLT-1 subtype of glutamate transporter. Requirement of a carboxyl-terminal domain and partial dependence on serine 486 J. Biol. Chem. 227 2002 45741 45750
10. K.P Lehre, L.M. Levy, O.P. Ottersen, J. Storm-Mathisen, and N.C. Danbolt Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations J. Neurosci. 15 1995 1835 1853
11. C.L. Lin, L.A. Bristol, L. Jin, M. Dykes-Hoberg, T. Crawford, L. Clawson, and J.D. Rothstein Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis Neuron 20 1998 589 602
12. H.A. Meijer, and A.A. Thomas Control of eukaryotic protein synthesis by upstream open reading frames in the 5′-untranslated region of an mRNA Biochem. J. 367 2002 1 11
13. T. Meyer, C. Münch, B. Knappenberger, S. Liebau, H. Völkel, and A.C. Ludolph Alternative splicing of the glutamate transporter EAAT2 (GLT-1) Neurosci. Lett. 241 1998 68 70
14. T. Meyer, A. Fromm, C. Münch, B. Schwalenstöcker, A.E. Fray, P.G. Ince, S. Stamm, G. Gron, A.C. Ludolph, and P.J. Shaw The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals J. Neurol. Sci. 170 1999 45 50
15. C. Münch, B. Schwalenstöcker, B. Knappenberger, S. Liebau, H. Völkel, A.C. Ludolph, and T. Meyer 5′-heterogeneity of the human excitatory amino acid transporter cDNA EAAT2 (GLT-1) NeuroReport 9 1998 1295 1297
16. C. Münch, B. Schwalenstöcker, C. Hermann, S. Cirovic, S. Stamm, A.C. Ludolph, and T. Meyer Differential RNA cleavage and polyadenylation of the glutamate transporter EAAT2 in the human brain Brain Res. Mol. Brain Res. 80 2000 244 251
17. C. Münch, A. Penndorf, B. Schwalenstöcker, D. Troost, A.C. Ludolph, P. Ince, and T. Meyer Impaired RNA splicing of 5′-regulatory sequences of the astroglial glutamate transporter EAAT2 in human astrocytoma J. Neurol. Neurosurg. Psychiatry 71 2001 675 678
18. C. Münch, M. Ebstein, U. Seefried, B. Zhu, S. Stamm, G.B. Landwehrmeyer, A.C. Ludolph, B. Schwalenstöcker, and T. Meyer Alternative splicing of the 5′-sequences of the mouse EAAT2 glutamate transporter and expression in a transgenic model for amyotrophic lateral sclerosis J. Neurochem. 82 2002 594 603
19. C. Münch, B.G. Zhu, A. Leven, S. Stamm, H. Einkorn, B. Schwalenstöcker, A.C. Ludolph, M.W. Riepe, and T. Meyer Differential regulation of 5′ splice variants of the glutamate transporter EAAT2 in an in vivo model of chemical hypoxia induced by 3-nitropropionic acid J. Neurosci. Res. 71 2003 819 825
20. G. Pines, N.C. Danbolt, M. Bjoras, Y. Zhang, A. Bendahan, L. Eide, H. Koepsell, J. Storm-Mathisen, E. Seeberg, and B.I. Kanner Cloning and expression of a rat brain L-glutamate transporter Nature 360 1992 464 467
21. P. Reye, R. Sullivan, H. Scott, and D.V. Pow Distribution of two splice variants of the glutamate transporter GLT-1 in rat brain and pituitary Glia 38 2002 246 255
22. J.D. Rothstein, L. Martin, A.I. Levey, M. Dykes-Hoberg, L. Jin, D. Wu, N. Nash, and R.W. Kuncl Localization of neuronal and glial glutamate transporters Neuron 13 1994 713 725
23. J. Rozyczka, M. Figiel, J. Engele, Endothelins negatively regulate glial glutamate transporter expression, Brain Pathol. In press.
24. K. Schlüter, M. Figiel, J. Rozyczka, and J. Engele CNS region-specific regulation of glial glutamate transporter expression Eur. J. Neurosci. 16 2002 836 842
25. A. Schmitt, E. Asan, K.P. Lesch, and P. Kugler A splice variant of glutamate transporter GLT1/EAAT2 expressed in neurons: cloning and localization in rat nervous system Neuroscience 109 2002 45 61
26. P. Shashidharan, I. Wittenberg, and A. Plaitakis Molecular cloning of human brain glutamate/aspartate transporter II Biochim. Biophys. Acta 1191 1994 393 396
27. K.D. Sims, and M.B. Robinson Expression patterns and regulation of glutamate transporters in the developing and adult nervous system Crit. Rev. Neurobiol. 13 1999 169 197
28. R. Sullivan, T. Rauen, F. Fischer, M. Wiessner, C. Grewer, A. Bicho, and D.V. Pow Cloning, transport properties, and differential localization of two splice variants of GLT-1 in the rat CNS: implications for CNS glutamate homeostasis Glia 45 2004 155 169
29. R. Torp, F. Hoover, N.C. Danbolt, J. Storm-Mathisen, and O.P. Otterson Differential distribution of the glutamate transporters GLT1 and rEAAC1 in rat cerebral cortex and thalamus: an in situ hybridization analysis Anat. Embryol. 195 1997 317 326
30. N. Utsunomiya-Tate, H. Endou, and Y. Kanai Tissue specific variants of glutamate transporter GLT-1 FEBS Lett. 416 1997 312 316
31. O. Zelenaia, B.D. Schlag, G.E. Gochenauer, R. Ganel, W. Song, J.S. Beesley, J.B. Grinspan, J.D. Rothstein, and M.B. Robinson Epidermal growth factor receptor agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on phosphatidylinositol 3-kinase and transcription factor NF-kappaB Mol. Pharmacol. 57 2000 667 678