The discovery of small molecule carbamates as potent dual α4β1/α4β7 integrin antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 2, 2002, Pages 159-163

  Chang, Linda L ^a   Truong, Quang ^a   Mumford, Richard A ^a   Egger, Linda A ^a   Kidambi, Usha ^a   Lyons, Kathryn ^a   McCauley, Ermengilda ^a   Van Riper, Gail ^a   Vincent, Stella ^a   Schmidt, John A ^a   MacCoss, Malcolm ^a   Hagmann, William K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4BETA1 INTEGRIN ANTAGONIST; ALPHA4BETA7 INTEGRIN; ALPHA4BETA7 INTEGRIN ANTAGONIST; CARBAMIC ACID DERIVATIVE; INTEGRIN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4;

ALKYLATION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; IC 50; INFLAMMATION; MOLECULE; NONHUMAN; PLASMA CLEARANCE; RAT; STRUCTURE ACTIVITY RELATION;

CARBAMATES; HUMANS; INTEGRIN ALPHA4BETA1; INTEGRINS; JURKAT CELLS; RECEPTORS, LYMPHOCYTE HOMING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18244388008     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00710-7     Document Type: Article

References (32)