Cell adhesion antagonists: Synthesis and evaluation of a novel series of phenylalanine based inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 14, 2000, Pages 1497-1499

  Harriman, Geraldine C B ^a   Schwender, Charles F ^a   Gallant, Debra ^a   Cochran, Nancy A ^a   Briskin, Michael J ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; INTEGRIN; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; PHENYLALANINE DERIVATIVE; PROTEIN INHIBITOR;

ANIMAL CELL; ARTICLE; CELL ADHESION; DRUG INHIBITION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; STRUCTURE ANALYSIS;

CELL ADHESION; HUMANS; IMMUNOGLOBULINS; INTEGRINS; LYMPHOMA, B-CELL; MOLECULAR STRUCTURE; MUCOPROTEINS; PHENYLALANINE; RECEPTORS, LYMPHOCYTE HOMING; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0034679648     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00300-0     Document Type: Article

References (16)

1. Butcher E.C. Cell. 67:1991;1033.
2. Springer T.A. Cell. 65:1994;301.
3. Brezinschek R.I., Brezinschek H.-P., Lazarovits A.I., Lipsky P.E., Oppenheimer-Marks N. Am. J. Pathol. 149:1996;1651.
4. Berlin, C.; Berg, E. L.; Briskin, M. J.; Andrew, D.; Kilshaw, P. J.; Holzmann, B.; Weissman, I. L.; Hainann, A.; Butcher, E. C. Cell 1993, 74.
5. Bargatze R.F., Jutila M.A., Butcher E.C. Immunity. 3:1995;99.
6. Briskin M., Winsor-Hines D., Shyan A., Cochran N., Bloom S., Wilson J., Butcher E.C., Kassam N., Mackay C.R., Newman W., Ringler D.J. Am. J. Pathol. 151:1997;97.
7. Picarella D., Hurlbut P., Rottman J., Shi X., Butcher E., Ringler D. J. Immunol. 158:1997;2099.
8. Hesterberg P.E., Winsor-Hines D., Briskin M.J., Soler-Ferran D., Merrill C., Mackay C.R., Newman W., Ringler D.J. Gastroenterology. 111:1996;1373.
9. Carson K.G., Schwender C.F., Shroff H.N., Cochran N.A., Gallant D.L., Briskin M. J Bioorg. Med. Chem. Lett. 7:1997;711.
10. Schroff H.N., Schwender C.F., Baxter A.D., Brookfield F., Payne L.J., Cochran N.A., Gallant D.L., Briskin M.J. Bioorg. Med. Chem. Lett. 8:1998;1601.
11. Shroff H.N., Schwender C.F., Dottavio D., Yang L., Briskin M.J. Bioorg. Med. Chem. Lett. 6:1996;2495.
12. Alig L., Edenhofer A., Hadvary P., Hurzeler M., Knopp D., Muller M., Steiner B., Trzeciak A., Weller T. J. Med. Chem. 35:1992;4393.
13. Borch R., Bernstein M., Durst H. J. Am. Chem. Soc. 93:1971;2897.
14. Dourtoglou, V.; Gross, B. Synthesis 1984, 572.
15. Hudson D. J. Org. Chem. 53:1988;617.
16. 13C NMR, and elemental analysis. All compounds assayed were >95% pure.