The discovery of sulfonylated dipeptides as Potent VLA-4 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 20, 2001, Pages 2709-2713

  Hagmann, William K ^a   Durette, Philippe L ^a   Lanza, Thomas ^a   Kevin, Nancy Jo ^a   De Laszlo, Stephen E ^a   Kopka, Ihor E ^a   Young, David ^a   Magriotis, Plato A ^a   Li, Bing ^a   Lin, Linus S ^a   Yang, Ginger ^a   Kamenecka, Theodore ^a   Chang, Linda L ^a   Wilson, Jonathan ^a   MacCoss, Malcolm ^a   Mills, Sander G ^a   Van Riper, Gail ^a   McCauley, Ermengilda ^a   Egger, Linda A ^a   Kidambi, Usha ^a   Lyons, Kathryn ^a   Vincent, Stella ^a   Stearns, Ralph ^a   Colletti, Adria ^a   Teffera, Johannes ^a   Tong, Sharon ^a   Fenyk Melody, Judy ^a   Owens, Karen ^a   Levorse, Dorothy ^a   Kim, Philip ^b   Schmidt, John A ^a   Mumford, Richard A ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b Peptidogenic Research and Co   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; BIPHENYL DERIVATIVE; CARBOXYLIC ACID; DIPEPTIDE DERIVATIVE; INTEGRIN; LEAD; PROTEIN INHIBITOR;

AREA UNDER THE CURVE; ARTICLE; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; NONHUMAN; RAT; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOLOGICAL AVAILABILITY; DIPEPTIDES; DOGS; INTEGRIN ALPHA4BETA1; INTEGRINS; MACACA MULATTA; METABOLIC CLEARANCE RATE; RATS; RECEPTORS, LYMPHOCYTE HOMING; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS;

EID: 0035935194     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00544-3     Document Type: Article

References (15)