Imide and lactam derivatives of N-benzylpyroglutamyl-L-phenylalanine as VCAM/VLA-4 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 1, 2001, Pages 1-4

  Tilley, Jefferson W ^a   Kaplan, Gerry ^a   Rowan, Karen ^a   Schwinge, Virginia ^a   Wolitzky, Barry ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO N BENZYLPYROGLUTAMYLPHENYLALANINE; AMINO ACID DERIVATIVE; BETA1 INTEGRIN; IMIDE; LACTAM DERIVATIVE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANTIGEN EXPRESSION; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IC 50; INFLAMMATION;

CELL ADHESION; DIPEPTIDES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMIDES; INHIBITORY CONCENTRATION 50; INTEGRIN ALPHA4BETA1; INTEGRINS; LACTAMS; MOLECULAR STRUCTURE; PHENYLALANINE; PYRROLIDONECARBOXYLIC ACID; RECEPTORS, LYMPHOCYTE HOMING; TUMOR CELLS, CULTURED;

EID: 0035825366     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00582-5     Document Type: Article

References (7)