Fischer indole synthesis on a solid support

Tetrahedron Letters

Volumn 37, Issue 28, 1996, Pages 4869-4872

  Hutchins, Steven M ^a   Chapman, Kevin T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; BUTYRIC ACID DERIVATIVE; INDOLE DERIVATIVE; PHENYLHYDRAZINE; RESIN; ZINC CHLORIDE;

ARTICLE; CYCLIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION TIME; SYNTHESIS; TEMPERATURE;

EID: 0030575421     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00997-5     Document Type: Article

References (4)

1. 1. Robinson, B. The Fischer Indole Synthesis; John Wiley & Sons: New York, 1982
2. 2. The resin used was purchased from Rapp Polymere (Polyethyleneglycol spacer on a polystyrene bead (130 micron, 0.23 mmol/g) - TentaGel S HMB - cat. # S30014).
3. 3. The resin used was purchased from Advanced ChemTech (Aminomethylated Polystyrene Resin, 200-400 mesh, catalog #SA5002). The HMB handle was loaded using PyBOP.
4. 4. Purity determined by HPLC. HPLC Conditions: 10 - 100% acetonitrile in water + 0.1% trifluoroacetic acid, linear gradient over 10 minutes, flow rate: 1.5 mL/min, Zorbax SB C8 column (4.6 mm x 7.5 cm), 254 nm.