In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line

Journal of Investigative Dermatology

Volumn 124, Issue 5, 2005, Pages 984-989

  Shimizu, Atsushi ^a   Ishiko, Akira ^a   Ota, Takayuki ^a   Saito, Hitoshi ^a   Oka, Hiroshi ^a   Tsunoda, Kazuyuki ^a   Amagai, Masayuki ^a   Nishikawa, Takeji ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Adhesion molecule; Cadherin; Immunoelectron microscopy; Pemphigus vulgaris

Indexed keywords

DESMOGLEIN 3; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL MEMBRANE; CONTROLLED STUDY; DESMOSOME; IMMUNOELECTRON MICROSCOPY; IN VIVO STUDY; MOUSE; NONHUMAN; PEMPHIGUS VULGARIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN LOCALIZATION;

EID: 18244380061     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2005.23706.x     Document Type: Article

References (29)

1. Amagai M, Klaus-Kovtun V, Stanley JR: Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell 67: 869-877, 1991
2. Amagai M, Tsunoda K, Suzuki H, Nishifugi K, Koyasu S, Nishikawa T: Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus. J Clin Invest 105:625-631, 2000
3. Blaschuk OW, Sullivan R, David S, Pouliot Y: Identification of a cadherin cell adhesion recognition sequence. Dev Biol 139:227-229, 1990
4. Chappuis-Flament S, Wong E, Hicks LD, Kay CM, Gumbiner BM: Multiple cadherin extracellular repeats mediate homophilic binding and adhesion. J Cell Biol 154:231-243, 2001
5. Garrod DR, Merritt AJ, Nie Z: Desmosomal adhesion: Structural basis, molecular mechanism and regulation (review). Mol Membrane Biol 19:81-94, 2002
6. Getsios S, Huen AC, Green KJ: Working out the strength and flexibility of desmosomes. Nat Rev Mol Cell Biol 5:271-281, 2004
7. He W, Cowin P, Stokes DL: Untangling desmosomal knots with electron tomography. Science 302:109-113, 2003
8. Kelly DE, Shienvold FL: The desmosome: Fine structural studies with freeze-fracture replication and tannic acid staining of sectioned epidermis. Cell Tissue Res 172:309-323, 1976
9. Kurzen H, Moll I, Moll R, et al: Compositionally different desmosomes in the various compartments of the human hair follicle. Differentiation 63: 295-304, 1998
10. Noe V, Willems J, Vandekerckhove J, Roy FV, Bruyneel E, Mareel M: Inhibition of adhesion and induction of epithelial cell invasion by HAV-containing E-cadherin-specific peptides. J Cell Sci 112:127-135, 1999
11. Nollet F, Kools P, van Roy F: Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. J Mol Biol 299:551-572, 2000
12. North AJ, Bardsley WG, Hyam J, et al: Molecular map of the desmosomal plaque. J Cell Sci 112:4325-4336, 1999
13. Nose A, Tsuji K, Takeichi M: Localization of specificity determining sites in cadherin cell adhesion molecules. Cell 61:147-155, 1990
14. Ohyama M, Amagai M, Tsunoda K, et al: Immunologic and histophathologic characterization of active disease mouse model for pemphigus vulgaris. J Invest Dermatol 118:199-204, 2002
15. Overduin M, Harvey TS, Bagby S, Tong KI, Yau P, Takeichi M, Ikura M: Solution structure of the epithelial cadherin domain responsible for selective cell adhesion. Science 267:386-389, 1995
16. 2+ binding site of uvomorulin abolish the adhesive function. Cell 63:1033-1038, 1990
17. 2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation. EMBO J 18:1738-1747, 1999
18. Rayns DG, Simpson FO, Ledingham JM: Ultrastructure of desmosomes in mammalian intercalated disc; appearances after lanthanum treatment. J Cell Biol 42:322-326, 1969
19. Runswick SK, O'Hare MJ, Jones L, Streuli CH, Garrod DR: Desmosomal adhesion regulates epithelial morphogenesis and cell positioning. Nat Cell Biol 3:823-830, 2001
20. Schmidt A, Heid HW, Schafer S, Nuber UA, Zimbelmann R, Franke WW: Desmosomes and cytoskeletal architecture in epithelial differentiation: Cell type-specific plaque components and intermediate filament anchorage. Eur J Cell Biol 65:229-245, 1994
21. Shapiro L, Fannon AM, Kwong PD, et al: Structural basis of cell-cell adhesion by cadherins. Nature 374:327-337, 1995
22. Shimizu A, Ishiko A, Ota T, Tsunoda K, Amagai M, Nishikawa T: IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model. J Invest Dermatol 122:1145-1153, 2004
23. Shimizu A, Ishiko A, Ota T, Tsunoda K, Koyasu S, Amagai M, Nishikawa T: Ultrastructural changes in mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris. Arch Dermatol Res 294:318-323, 2002
24. Shimizu H, McDonald JN, Kennedy AR, Eady RA: Demonstration of intra- and extracellular localization of bullous pemphigoid antigen using cryofixation and freeze substitution for postembedding immunoelectron microscopy. Arch Dermatol Res 281:443-448, 1989
25. Sivasankar S, Brieher W, Lavrik N, Gumbiner B, Leckband D: Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains. Proc Natl Acad Sci USA 96:11820-11824, 1999
26. Sivasankar S, Gumbiner B, Leckband D: Direct measurements of multiple adhesive alignments and unbinding trajectories between cadherin extracellular domains. Biophys J 80:1758-1768, 2001
27. Stanley JR: Cell adhesion molecules as targets of autoantibodies in pemphigus and pemphigoid, bullous diseases due to defective epidermal cell adhesion. Adv Immunol 53:291-325, 1993
28. Tselepis C, Chidgey M, North A, Garrod D: Desmosomal adhesion inhibits invasive behavior. Proc Natl Acad Sci USA 95:8064-8069, 1998
29. Tsunoda K, Ota T, Aoki M, et al: Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3. J Immunol 170:2170-2178, 2003