Similarities and differences between the responses of rat sensory neurons to noxious heat and capsaicin

Journal of Neuroscience

Volumn 19, Issue 24, 1999, Pages 10647-10655

  Nagy, Istvan ^a,b   Rang, Humphrey P ^a  

^a Novatis Inst for Medical Sciences   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

Author keywords

Capsaicin; Heat; Sensory neurons; Single channel; VR1; Wholecell

Indexed keywords

CAPSAICIN; ION CHANNEL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HEAT; MEMBRANE CHANNEL; NERVE CELL CULTURE; NOCICEPTION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SPINAL GANGLION;

EID: 0033573378     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-24-10647.1999     Document Type: Article

References (28)

1. Bevan SJ, Docherty RJ (1993) Cellular mechanisms of the action of capsaicin. In: Capsaicin in the study of pain (Wood JN, ed), pp 27-44. London: Academic.
2. Bevan SJ, Szolcsanyi J (1990) Sensory neuron-specific actions of capsaicin: mechanisms and applications. Trends Pharmacol Sci 11:330-333.
3. Bevan S, Hothi S, Hughes G, James IF, Rang HP, Shah K, Walpole CSJ, Yeats JC (1992) Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin. Br J Pharmacol 107:544-552.
4. Campbell JN, Meyer RA (1996) Cutaneous nociceptors. In: Neurobiologyof nociceptors (Belmonte CF, Cervero F, eds), pp 117-145. Oxford: Oxford UP.
5. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816-824.
6. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (1999) A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398:436-441.
7. Cesare P, McNaughton P (1996) A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin. Proc Natl Acad Sci USA 93:15435-15439.
8. Chung S-H, Kuyucak S (1995) Changes in the conductance and kinetics of N-methyl-D-aspartate (NMDA)-receptor activated single channels with temperature. Neurosci Lett 187:181-184.
9. Colquhoun D, Sigworth FJ (1995) Fitting and statistical analysis of single channel records. In: Single channel recording (Sakmann B, Neher E, eds), pp 397-482. New York: Plenum.
10. Dray A, Forbes CA, Burgess GM (1990) Ruthenium red blocks the capsaicin-induced increase in intracellular calcium and activation of membrane currents in sensory neurones as well as the activation of peripheral nociceptors in vitro. Neurosci Lett 110:52-59.
11. Hammill OP, Marly A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391:85-100.
12. Hille B (1992) Ionic channels of excitable membranes. Sunderland, MA: Sinauer.
13. Kirschstein T, Busselberg D, Treede RD (1997) Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons. Neurosci Lett 231:33-36.
14. Leaney JL, Marsh SJ, Brown DA (1977) A swelling-activated chloride current in rat sympathetic neurones. J Physiol (Lond) 501:555-564.
15. Lewis CA (1979) Ion concentration dependence of the reversal potential and the single channel conductance of ion channels at the frog neuromuscular junction. J Physiol (Lond) 86:417-445.
16. Lindsay RM (1988) Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons. J Neurosci 8:2394-2405.
17. Maggi CA, Bevan S, Walpole CS, Rang HP, Giuliani S (1993) A comparison of capsazepine and ruthenium red as capsaicin antagonists in the rat isolated urinary bladder and vas deferens. Br J Pharmacol 108:801-805.
18. Michael GJ, Priestley JV (1999) Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy. J Neurosci 19:1844-1854.
19. Nagy I, Rang HP (1997) Noxious heat-activated currents in rat dorsal root ganglion neurons. J Physiol (Lond) 506:153P.
20. Nagy I, Rang HP (1998) Noxious heat-activated microscopic currents in rat dorsal root ganglion neurones. J Physiol (Lond) 607:29P.
21. Nagy I, Rang HP (1999) Noxious heat activates all capsaicin-sensitive and also a sub-population of capsaicin-insensitive dorsal root ganglion neurons. Neuroscience 88:995-997.
22. Oh U, Hwang SW, Kim D (1996) Capsaicin activates a non-selective cation channel in cultured rat dorsal root ganglion neurons. J Neurosci 16:659-1667.
23. Reichling DB, Levine JD (1997) Heat transduction in rat sensory neurons by calcium-dependent activation of a cation channel. Proc Natl Acad Sci USA 94:7006-7011.
24. Szallasi A, Blumberg PM (1990) Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes. Brain Res 524:106-121.
25. Szolcsanyi J, Anton F, Reeh PW, Handwerker HO (1988) Selective excitation by capsaicin of mechano-heat sensitive nociceptors in rat skin. Brain Res 446:262-268.
26. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Bashaum AI, Julius D (1998) The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21:531-543.
27. Vycklicky L, Vlachova V, Vitaskova Z, Dittert I, Kabat M, Orkand RK (1999) Tempreature coefficient of membrane currents evoked by noxious heat in sensory neurones of the rat. J Physiol (Lond) 517:181-192.
28. Wood JN, Winter J, James IF, Rang HP, Yeats J, Bevan S (1988) Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture. J Neurosci 8:3208-3220.