Quantitation of the change in GADD153 messenger RNA level as a molecular marker of tumor response in head and neck cancer

Clinical Cancer Research

Volumn 5, Issue 7, 1999, Pages 1610-1618

  Los, Gerrit ^a   Benbatoul, Khalid ^a   Gately, Dennis P ^a   Barton, Racine ^a   Christen, Randolph ^a   Robbins, K Thomas ^b   Vicario, Daniel ^a   Kirmani, Saeeda ^a   Orloff, Lisa A ^a   Weisman, Robert ^a   Howell, Stephen B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; MESSENGER RNA; SODIUM THIOSULFATE;

ARTICLE; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; DNA DAMAGE; DRUG DNA BINDING; DRUG EFFICACY; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; QUANTITATIVE ASSAY; TRANSCRIPTION REGULATION; TREATMENT OUTCOME;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL MARKERS; CCAAT-ENHANCER-BINDING PROTEINS; CISPLATIN; DISEASE PROGRESSION; DNA-BINDING PROTEINS; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; OUTCOME ASSESSMENT (HEALTH CARE); POLYMERASE CHAIN REACTION; QUALITY CONTROL; RNA, MESSENGER; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0032766918     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Büscher, M., Rahmsdorf, H. J., Litfin, M., Karin, M., and Herrlich, P. The activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element. Oncogene, 3: 301-311, 1988.
2. Futscher, B. W., and Erickson, L. C. Changes in c-myc and c-fos expression in a human tumor cell line following exposure to bifunctional alkylating agents. Cancer Res., 50: 62-66, 1990.
3. Rubin, E., Kharbanda, S., Gunji, H., Weichselbaum, R., and Kufe, D. cis-diamminedichloroplatinum(II) induces c-jun expression in human myeloid leukemia cells: potential involvement of a protein kinase C-dependent signaling pathway. Cancer Res., 52: 878-882, 1992.
4. Karin, M., and Herrlich, P. Cis-and trans-acting genetic elements responsible for induction of specific genes by tumor promoters, serum factors, and stress. In: N. H. Colburn (ed.), Genes and Signal Transduction in Multistage Carcinogenesis, pp.425-440. New York: Marcel Dekker, Inc., 1989.
5. Holbrook, N. J., and Fornace, A. J. Response to adversity: molecular control of gene activation following genotoxic stress. New Biol., 3: 825-833, 1991.
6. Fornace, A. J., Nebert, D. W., Hollander, M. C., Luethy, J. D., Papathanasiou, M., Fragoli, J., and Holbrook, N. J. Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents. Mol. Cell. Biol., 9: 4196-4203, 1989.
7. Luethy, J. D., Fragnoli, J., Park, J. S., Fornace, A. J., Jr., and Holbrook, N. J. Isolation and characterization of the hamster gadd153 gene. J. Biol. Chem., 265: 16521-16526, 1990.
8. Park, J. S., Luethy, J. D., Wang, M. G., Fargnoli, J., Fornace, A. J., Jr., McBride, O. W., and Holbrook, N. J. Isolation, characterization and chromosomal localization of the human gadd153 gene. Gene, 116: 259-267, 1992.
9. Fornace, A. J., Jr., Nebert, D. W., Hollander, C., Luethy, J. D., Papathanasiou, M., Fargnoli, J., and Holbrook, N. Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents. Mol. Cell. Biol., 10: 4196-4203, 1989.
10. Luethy, J. D., and Holbrook, N. J. Activation of the gadd153 promoter by genotoxic agents: a rapid and specific response to DNA damage. Cancer Res., 52: 5-10, 1992.
11. Price, B., and Calderwood, S. Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of glucoes regulated proteins. Cancer Res., 52: 33814-3817, 1992.
12. Wang, X-Z., and Ron, D. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science (Washington DC), 272: 1347-1349, 1996.
13. Wang, X-Z., Lawson, B., Brewer, J. W., Zinszner, H., Sanjay, A., Mi, L-J., Boorstein, R., Kreibich, G., Hendershot, L. M., and Ron, D. Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Mol. Cell. Biol., 16: 4273-4280, 1996.
14. Eymin, B., Dubrez, L., Allouche, M., and Solary, A. Increased gadd153 messenger RNA level is associated with apoptosis in human leukemic cells treated with etoposide. Cancer Res., 57: 686-695, 1997.
15. Wang, X-Z., Kuroda, M., Sok, J., Batchvarova, N., Kimmel, R., Chung, P., Zinszner, H., and Ron, D. Identification of novel stress-induced genes downstream of chop. EMBO J., 17: 3619-3630, 1998.
16. Gately, D. P., Sharma, A., Christen, R. D., and Howell, S. B. Cisplatin and taxol activate different signal pathways regulating cellular injury-induced expression of GADD153. Br. J. Cancer, 73: 18-23, 1996.
17. Gately, D. P., Jones, J. A., Christen, R., Barton, R., Los, G., and Howell, S. B. Induction of growth arrest and DNA damage inducible gene gadd153 by cisplatin in vitro and in vivo. Br. J. Cancer, 70: 1102-1106, 1994.
18. Los, G., Barton, R. M., Nakata, B., Lee, L. K., van Veelen, L. R., and Howell, S. B. DNA damage and early-response genes as a tool to monitor tumor injury following chemotherapy. Proc. Am. Assoc. Cancer Res., 34: 433, 1993.
19. Friedman, A. D. GADD153/CHOP, a DNA damage-inducible protein, reduced CAAT/enhancer binding protein activities and increased apoptosis in 32D c13 myeloid cells. Cancer Res., 56: 3250-3256, 1996.
20. Los, G., Barton, R., van Veelen, L., Woods, A., Vicario, D., Robbins, K. T., and Howell, S. B. Association between DNA damage-inducible gene expression and tumor response. Proc. Am. Assoc. Cancer Res., 35: 550, 1994.
21. Ou, Y. C., Thompson, S. A., Kirchner, S. C., Kavanagh, T. J., and Faustman, E. M. Induction of growth arrest and DNA damage-inducible genes Gadd45 and Gadd153 in primary rodent embryonic cells following exposure to methylmercury. Toxicol. Appl. Pharmacol., 147: 31-38, 1997.
22. Grenman, R., Burk, D., Virolainen, E., Buick, R. N., Church, J., Schwartz, D. R., and Carey, T. E. Clonogenic cell assay for anchorage-dependent squamous carcinoma cell lines using limiting dilution. Int. J. Cancer, 44: 131-136, 1989.
23. Nakata, B., Barton, R. M., Robbins, T. K., Howell, S. B., and Los, G. Association between hsp60 mRNA levels and cisplatin resistance in human head and neck cancer cell lines. Int. J. Oncol., 6: 1425-1432, 1994.
24. Nakata, B., Albright, K. D., Barton, R. M., Howell, S. B., and Los, G. Synergistic interaction between cisplatin and tamoxifen and the delay of cisplatin resistance in head and neck carcinoma cell lines. Cancer Chemother. Pharmacol., 35: 511-518, 1995.
25. Robbins, R. T., Vicario, D., Seagren, S., Weisman, R., Pelliterri, P., Kerber, C., Orloff, L., Los, G., and Howell, S. B. A targeted supradose cisplatin chemoradiation protocol for advanced head and neck cancer. Am. J. Surg., 168: 419-422, 1994.
26. Robbins, K. T., Storniolo, A. M., Kerber, C., Vicario, D., Seagren, S., Shea, M., Hanchett, C., Los, G., and Howell, S. B. Phase I study of highly selective supradose cisplatin infusion for advanced head and neck cancer. J. Clin. Oncol., 12: 2113-2120, 1994.
27. Weisman, R. A., Christen, R., Los, G., Jones, V., Kerber, C., Seagren, S., Glassmeyer, S., Orloff, L. A., Wong, W., Kirmani, S., and Howell, S. Phase I trial of retinoic acid and cis-platinum for advanced squamous cell cancer of the head and neck based on experimental evidence of drug synergism. Otolaryngol. Head Neck Surg., 118: 597-602, 1998.
28. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
29. Horikoshi, T., Danenberg, K. D., Stadlbauuer, T. H. W., Volkenandt, M., Shea, L. C. C. Aigner, K., Gustavsson, B., Leichman, L., Frösing, R., Ray, M., Gibson, N. W., Spears, P. C., and Danenberg, P. V. Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Res., 52: 108-116, 1992.
30. Sambrook, J., Fritch, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989.
31. Davis, L. G., Bidner, M. D., and Battey, J. F. Basic Methods in Molecular Biology. New York: Elsevier, 1986.
32. Jones, J. A., Gately, D. P., Barton, R. C., Albright, K. D., Christen, R. D., McClay, E. F., Los, G., and Howell, S. B. Induction of gadd153 in human melanoma xenografts as an indicator of genotoxic injury. Cell. Pharmacol., 1: 233-237, 1994.
33. Howell, S. B., Gately, D. P., Christen, R. D., and Los, G. The cisplatin induced cellular injury response. In: H. M. Pinedo and J. H. Schornagel (eds.), Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2, pp. 269-282. New York and London: Plenum Press, 1996.
34. Fornace, A. J., Jackman, J., Hollander, M. C., Hoffman-Lieberman, B., and Lieberman, D. H. Genotoxic-stress-response genes and growth-arrest-genes. Anal. NY Acad. Sci., 663: 139-153, 1992.
35. Luethy, J. D., and Holbrook, N. J. The pathway regulating gadd153 induction in response to DNA damage is independent of protein kinase C of tyrosine kinases. Cancer Res., 54: 1902-1906, 1994.
36. Devary, Y., Gottlieb, R. A., Lau, L. F., and Karin, M. Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol. Cell. Biol., 11: 2804-2811, 1991.
37. Wang, X-Z., and Ron, D. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science (Washington DC), 1347-1349, 1996.
38. Gasparini, G., Bevilacque, P., Bonoldi, E., Testolin, A., Galassi, A., Verderio, P., Boracchi, P., Guglielmi, R. B., and Pezzella, F. Predictive and prognostic markers in a series of patients with head and neck squamous cell invasive carcinoma treated with concurrent chemoradiation therapy. Clin. Cancer Res., 1: 1375-1383, 1995.
39. Johnsson, A., Strand, C., and Los, G. Expression of GADD153 in tumor cells and stromal cells from xenografted tumors in nude mice treated with cisplatin: correlation with cisplatin-DNA adducts. Cancer Chemother. Pharmacol., 43: 348-352, 1999.