MDM2 mediated nuclear exclusion of p53 attenuates etoposide-induced apoptosis in neuroblastoma cells

Molecular Pharmacology

Volumn 59, Issue 1, 2001, Pages 135-143

  Rodriguez Lopez, Ana M ^a   Xenaki, Dia ^b   Eden, Tim O B ^c   Hickman, John A ^d   Chresta, Christine M ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c CHRISTIE HOSPITAL   (United Kingdom)

^d INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; ETOPOSIDE; PROTEIN MDM2; PROTEIN P21; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE TRANSLOCATION; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0035162434     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.59.1.135     Document Type: Article

References (38)

1. Differential regulation of p21(waf-1/cip-1) and Mdm2 by etoposide: Etoposide inhibits the p53-Mdm2 auto-regulatory feedback loop
2. Recruitment of p300/CBP in p53-dependent signal pathways
3. Mdm2 expression is induced by wild type p53 activity
4. Differential induction of secondary DNA fragmentation by topoisemerase II inhibitors in human tumor cell lines with amplified c-myc expression
5. p53-dependent apoptosis in the absence of transcriptional activation of p53- target genes
6. No TP53 mutations in neuroblastomas detected by PCR-SSCP analysis
7. Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage
8. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
9. Hypersensitivity of human testicuiar tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio
10. Phenotypic diversification in human neuroblastoma cells: Expression of distinct neuronal crest lineages
11. Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines
12. The complexity of p53 modulation: Emerging patterns from divergent signals
13. The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization
14. Regulation of Bcl-2 oncoprotein levels with differentiation of human neuroblastoma cells
15. Determinants of the response of neuroblastoma cells to DNA damage: The roles of pre-treatment cell morphology and chemical nature of the damage
16. Induction of apoptosis in HeLa cells by trans-activation-deficient p53
17. Low frequency of the p53 gene mutations in neuroblastoma
18. Differential subcellular p53 localization and function in N- and S-Type neurblastoma cell lines
19. Neuroblastoma: Review of the literature and an examination of its enigmatic character
20. Fractionation of DNA from mammalian cells by alkaline elution
21. Mdm-2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis
22. Nuclear exclusion of p53 in a subset of tumors requires MDM2 function
23. Histiogenesis and histopathology of neuroblastoma
24. Twenty years of p53 research: Structural and functional aspects of the p53 protein
25. Attenuated G1 arrest in neuroblastoma is mediated by defects downstream of the p21waf-1/ cip-1 pathway
26. Wild type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors
27. Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage
28. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
29. Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide
30. WAF1 is required for survival of differentiating neuroblastoma cells
31. Restoration of p53 nuclear localisation and apoptosis in neoroblastoma cells by antisense MDM-2
32. Induction of HL-60 cells to undergo apoptosis is determined by high levels of wild-type p53 protein whereas differentiation of the cells is mediated by lower p53 levels
33. Co-ordinate morphological and biological interconversion of human neuroblastoma cells
34. In vivo CPT-11 treatment leads to differentiation of neuroblastoma xenografts and topoisomerase I alterations
35. Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B
36. A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by p53 masking
37. Absence of p53 gene mutations in primary neuroblastomas