Growth and DNA Damage-Inducible Transcription Factor 153 Mediates Apoptosis in Response to Fenretinide but Not Synergy between Fenretinide and Chemotherapeutic Drugs in Neuroblastoma

Molecular Pharmacology

Volumn 64, Issue 6, 2003, Pages 1370-1378

  Corazzari, Marco ^a   Lovat, Penny E ^b,c   Oliverio, Serafina ^c   Pearson, Andy D J ^b   Piacentini, Mauro ^a   Redfern, Christopher P F ^b,d  

^a NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; ETOPOSIDE; FENRETINIDE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN BCL 2; TETRACYCLINE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENTIATION; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NEUROBLASTOMA; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN FAMILY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE, TUMOR; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FENRETINIDE; HUMANS; NEUROBLASTOMA; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS;

EID: 0345735767     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.6.1370     Document Type: Article

References (36)

1. Adler V, Yin Z, Fuchs SY, Benezra M, Rosario L, Tew KD, Pincus MR, Sardana M, Henderson CJ, Wolf CR, et al. (1999) Regulation of JNK signaling by GSTp. EMBO (Eur Mol Biol Organ) J 18:1321-1334.
2. Barone MV, Crozat A, Tabaee A, Philipson L, and Ron D (1994) CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest. Genes Dev 8:453-464.
3. Bernardini S, Bellincampi L, Ballerini S, Ranalli M, Pastore A, Cortese C, and Federici G (2002) Role of GST P1-1 in mediating the effect of etoposide on human neuroblastoma cell line SH-SY5Y. J Cell Biochem 86:340-347.
4. Biedler JL, Helsan L, and Spengler BA (1973) Morphology and growth, tumorigenicity and cytogenetics of human neuroblastoma cells in continuous culture. Cancer Res 33:2643-2652.
5. Bjorling-Poulsen M and Issinger OG (2003) cDNA array analysis of alterations in gene expression in the promyelocytic leukemia cell line, HL-60, after apoptosis induction with etoposide. Apoptosis 8:377-388.
6. Brenner B, Koppenhoefer U, Weinstock C, Linderkamp O, Lang F, and Gulbins E (1997) Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153. J Biol Chem 35:22173-22181.
7. Chou TC (1991) The median-effect principle and the combination index for quantification of synergism and antagonism, in Synergism and Antagonism in Chemotherapy (Chou TC and Rideout DC eds), pp 61-102, Academic Press, San Diego.
8. Chou TC and Talalay P (1984) Quantitative analysis of dose-effect relationships: the combined effect of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22:27-55.
9. de las Alas MM, Christen RD, Gately DP, Weiner DE, Benbatoul K, Kirmani S, Dagostino HR, Plaxe SC, Darrah D, McClay EF, et al. (2000) Increase in tumor GADD153 mRNA level following treatment correlates with response to paclitaxel. Cancer Chemother Pharmacol 45:381-388.
10. Dressler V, Muller G, and Suhnel J (1999) CombiTool-a new computer program for analysing combination experiments with biologically active agents. Comput Biomed Res 32:145-160.
11. Eymin B, Dubrez L, Allouche M, and Solary E (1997) Increased GADD153 messenger RNA level is associated with apoptosis in human leukemic cells treated with etoposide. Cancer Res 57:686-695.
12. Gabler WL and Creamer HR (1991) Suppression of human neutrophil functions by tetracyclines. J Periodontal Res 26:52-58.
13. Gotoh T, Oyadomari S, Mori K, and Mori M (2002) Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. J Biol Chem 277:12343-12350.
14. Guyton KZ, Xu Q, and Holbrook NJ (1996) Induction of the mammalian stress response gene GADD153 oxidative stress by oxidative stress: role of AP-1 element. Biochem J 314:546-554.
15. Kagan VE, Kuzmenko AI, Tyurina YY, Shvedova AA, Matsura T, and Yalowich JC (2001) Pro-oxidant and antioxidant mechanisms of etoposide in HL-60 cells: role of myeloperoxidase. Cancer Res 61:7777-7784.
16. Kim R, Inoue H, Aogi K, and Toge T (1999) Introduction of GADD153 into gastric cancer cells can modulate sensitivity to anticancer agents in association with apoptosis. Anticancer Res 19:1179-1184.
17. Lasorella A, Iavarone A, and Israel MA (1995) Differentiation of neuroblastoma enhances Bcl-2 expression and induces alterations of apoptosis and drug resistance. Cancer Res 55:4711-4716.
18. Los G, Benbatoul K, Gately DP, Barton R, Christen R, Robbins KT, Vicario D, Kirmani S, Orloff LA, Weisman R, et al. (1999) Quantitation of the change in GADD 153 messenger RNA level as a molecular marker of tumor response in head and neck cancer. Clin Cancer Res 7:1610-1618.
19. Lovat PE, Oliverio S, Ranalli M, Corazzari M, Rodolfo C, Bernassola F, Aughton K, Maccarrone M, Campbell Hewson QD, Pearson ADJ, et al. (2002) GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma. Cancer Res 62:5158-5167.
20. Lovat PE, Ranalli M, Annichiarrico-Petruzzelli M, Bernassola FMP, Malcolm AJ, Pearson ADJ, Melino G, and Redfern CPF (2000a) Effector mechanisms of fenretinide-induced apoptosis in neuroblastoma. Exp Cell Res 260:50-60.
21. Lovat PE, Ranalli M, Bernassola F, Tilby MJ, Malcolm AJ, Pearson ADJ, Piacentini M, Melino G, and Redfern CPF (2000b) Synergistic induction of apoptosis of neuroblastoma by fenretinide or CD437 in combination with chemotherapeutic drugs. Int J Cancer 88:977-985.
22. Mandic A, Hansson J, Linder S, and Shoshan MC (2003) Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J Biol Chem 278:9100-9106.
23. Maris JM and Matthay KK (1999) Molecular biology of neuroblastoma. J Clin Oncol 17:2264-2279.
24. Matsumoto M, Minami M, Takeda K, Sakao Y, and Akira S (1996) Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett 395:143-147.
25. Matthay KK, Villablanca JG, Seeger RC, Stram DO, Harris RE, Ramsy NK, Swift P, Shimada H, Black CT, Brodeur GM, et al. (1999) Treatment of high risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation and 13-cis retinoic acid. N Engl J Med 341:1165-1173.
26. Maurer BJ, Metelitsa LS, Seeger RC, Cabot MC, and Reynolds CP (1999) Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)-retinamide in neuroblastoma cell lines. J Natl Cancer Inst 91:1138-1146.
27. McCullough KD, Martindale JL, Klotz LO, Aw TY, and Holbrook NJ (2001) Gadd 153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21:1249-1259.
28. Meister B, Fink FM, Hittmair A, Marth C, and Widschwendter M (1998) Antiproliferative activity and apoptosis induced by retinoic acid receptor-γ selectively binding retinoids in neuroblastoma. Anticancer Res 18:1777-1786.
29. Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E, and Mori M (2002) Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Investig 109:525-532.
30. Reynolds CP and Lemons RS (2001) Retinoid therapy of childhood cancer. Hematol Oncol Clin North Am 15:867-910.
31. Ron D and Habener JF (1992) CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 6:439-453.
32. Tikka T, Usenius T, Tenhunen M, Keinanen R, and Koistinaho J (2001) Tetracycline derivatives and ceftriaxone, a cephalosporin antibiotic, protect neurons against apoptosis induced by ionizing radiation. J Neurochem 78:1409-1414.
33. Tombal B, Weeraratna AT, Denmeade SR, and Isaacs JT (2000) Thapsigargin induces a calmodulin/calcineurin-dependent apoptotic cascade responsible for the death of prostatic cancer cells. Prostate 43:303-317.
34. Tyurina YY, Tyurin VA, Yalowich JC, Quinn PJ, Claycamp HG, Schor NF, Pitt BR, and Kagan VE (1995) Phenoxyl radicals of etoposide (VP-16) can directly oxidize intracellular thiols: protective versus damaging effects of phenolic antioxidants. Toxicol Appl Pharmacol 131:277-288.
35. Vivo C, Liu W, and Broaddus VC (2003) c-Jun N-terminal kinase contributes to apoptotic synergy induced by TRAIL plus DNA damage in chemoresistant, p53 inactive mesothelioma cells. J Biol Chem 278:25461-25467.
36. Wang X, Lawson B, Brewer JW, Zinszner H, Sanjay A, Mi LJ, Boorstein R, Kreibich G, Hendershot LM, and Ron D (1996) Signals from the stressed endoplasmic reticulum induce C/ERP-homologous protein (CHOP/GADD153). Mol Cell Biol 16:4273-4280.