Expression, function, and regulation of E-type prostaglandin receptors (EP3) in the nonischemic and ischemic pig heart

Circulation Research

Volumn 81, Issue 5, 1997, Pages 765-773

  Hohlfeld, Thomas ^a   Zucker, Tom Philipp ^a   Meyer, Jutta ^a   Schrör, Karsten ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Adenylyl cyclase; E type prostaglandin receptor; Myocardial ischemia; Prostaglandin E1; Sarcolemma

Indexed keywords

ADENYLATE CYCLASE; GUANINE NUCLEOTIDE BINDING PROTEIN; PROSTACYCLIN; PROSTAGLANDIN E1; PROSTAGLANDIN E3; PROSTAGLANDIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RECEPTOR DENSITY; RECEPTOR UPREGULATION; SARCOLEMMA; SWINE;

EID: 0030722613     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.81.5.765     Document Type: Article

References (39)

1. Schrör K, Hohlfeld T. Inotropic actions of eicosanoids. Basic Res Cardiol. 1993;87:2-11.
2. Schrör K. Eicosanoids and myocardial ischemia. Basic Res Cardiol. 1986;82(suppl 1):235-243.
3. Schrör K, Hohlfeld T. Eicosanoids and the ischemic myocardium. In: Piper HM, ed. Pathophysiology of Severe Ischemic Myocardial Injury. Dordrecht, Netherlands: Kluwer Academic Publishers; 1990: 195-217.
4. van der Giessen WJ, Schoutsen B, Tijssen JGP, Verdouw PD. Iloprost (ZK 36374) enhances recovery of regional myocardial function during reperfusion after coronary occlusion and reperfusion in the pig. Br J Pharmacol. 1986;87:23-27.
5. Stürzebecher S, McDonald FM, Grundmann G, Hartmann S, Lammert C. Myocardial ischaemia and reperfusion in the anaesthetized pig: reduction of infarct size and myocardial enzyme release by the stable prostacyclin analogue iloprost. In: Schrör K, Sinzinger H, eds. Prostaglandins in Clinical Research. 301st ed. New York, NY: Alan R Liss Inc; 1988:155-160.
6. Hohlfeld T, Strobach H, Schrör K. Stimulation of endogenous prostacyclin protects the reperfused ischemic pig myocardium from ischemic injury. J Pharmacol Exp Ther. 1993;264:397-405.
7. 1 and cardiac arrhythmia. Eur J Pharmacol. 1972;18:392-395.
8. 2 preliminary results. In: Bergström S, Bernhard S, eds. Advances in the Biosciences: International Conference on Prostaglandins, Vienna, 1972. Oxford, UK: Pergamon; 1973:385-393.
9. Coker SJ, Parratt JR. Prostacyclin-antiarrhythmic or arrhythmogenic?: comparison of the effects of intravenous and intracoronary prostacyclin and ZK 36374 during coronary artery occlusion and reperfusion in anaesthetized greyhounds. J Cardiovasc Pharmacol. 1983;5:557-567.
10. Coleman RA, Smith WL, Narumiya S. VIII International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev. 1994;46:205-229.
11. Lopaschuk GD, Michalak M, Wandler EL, Lerner RW, Piscione TD, Coceani F, Olley PM. Prostaglandin E receptors in cardiac sarcolemma: identification and coupling to adenylate cyclase. Circ Res. 1989;65:538-545.
12. Maisel AS, Motulsky HJ, Insel PA. Externalization of β-adrenergic receptors promoted by myocardial ischemia. Science. 1985;230:183-186.
13. Strasser RH, Krimmer J, Marquetant R. Regulation of beta-adrenergic receptors: impaired desensitization in myocardial ischemia. J Cardiovasc Pharmacol. 1988;12(suppl 1):S15-S24.
14. Vatner DE, Knight DR, Shen YT, Thomas JX, Homcy CJ, Vatner SF. One hour of myocardial ischemia in conscious dogs increases β-adrenergic receptors, but decreases adenylate cyclase activity. J Mol Cell Cardiol. 1988;20:75-82.
15. Jones LR. Rapid preparation of canine cardiac sarcolemmal vesicles by sucrose flotation. Methods Enzymol. 1988;157:85-91.
16. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of dye-protein binding. Anal Biochem. 1976;72:248-254.
17. Jaschonek K, Karsch KR, Weisenberger H, Tidow S, Faul C, Renn W. Platelet prostacyclin binding in coronary artery disease. J Am Coll Cardiol. 1986;8:259-266.
18. +-ATPase-G protein coupling in myocardial sarcolemma: separation and reconstitution. Am J Physiol. 1991;261:H87-H91.
19. Fleming JW, Watanabe AM. Muscarinic cholinergic-receptor stimulation of specific GTP hydrolysis related to adenylate cyclase activity in canine sarcolemma. Circ Res. 1988;64:340-250.
20. Tso JY, Sun XH, Kao TH, Reece KS, Wu R. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Nucleic Acids Res. 1985;13:2485-2502.
21. 3 determines G-protein specificity. Nature. 1993;365:166-170.
22. Kang JX, Yunyuan LI, Leaf A. Differential effects of various eicosanoids on the contraction of cultured neonatal rat cardiac myocytes. Prostaglandins Leukot Essent Fatty Acids. 1996;55:128. Abstract.
23. 2 receptor transduce both intracellular calcium and cAMP signals. Biochemistry. 1994;33:14496-14502.
24. 3 receptor with different carboxyl-terminal domains. J Biol Chem. 1993;268:2712-2718.
25. 0 of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels. Br J Pharmacol. 1995;116:2435-2440.
26. Mukherjee AL, Bush LR, McCoy KE, Duke RJ, Hagler H, Buja LM, Willerson JT. Relationship between β-adrenergic receptor numbers and physiological responses during experimental canine myocardial ischemia. Circ Res. 1982;50:735-741.
27. Muntz KH, Olson EG, Lariviere GR, D'Souza S, Mukherjee A, Willerson JT, Buja LM. Autoradiographic characterization of beta adrenergic receptors in coronary blood vessels and myocytes in normal and ischemic heart. J Clin Invest. 1984;73:349-357.
28. Limas CJ, Limas C. Effects of xamoterol on the reversible cycling of cardiac adrenoceptors. J Cardiovasc Pharmacol. 1990;16:945-951.
29. Yonemochi H, Saikawa T, Takakura T, Ito S, Takaki R. Effects of calcium antagonists on β-receptors of cultured cardiac myocytes isolated from neonatal rat ventricle. Circulation. 1990;81:1401-1408.
30. 2 receptor antagonist binding site in human platelets. Biochem Pharmacol. 1987;37:647-654.
31. 2 receptors in patients with acute myocardial infarction. Circulation. 1990;65:538-545.
32. Schrör K, Funke K. Prostaglandins and myocardial noradrenaline overflow after sympathetic nerve stimulation during ischemia and reperfusion. J Cardiovasc Pharmacol. 1985;7(suppl 5):S50-S54.
33. Kurachi Y, Nakajima T, Ito H. Intracellular fluoride activation of muscarinic K channel in atrial cell membrane. Circulation. 1987;76(suppl IV):IV-105. Abstract.
34. Matesic DF, Manning DR, Luthin GR. Tissue-dependent association of muscarinic acetylcholine receptors with guanine nucleotide-binding regulatory proteins. Mol Pharmacol. 1991;40:347-353.
35. 1 receptors by G proteins in rat ventricular myocytes. Am J Physiol. 1990;259:H820-H826.
36. Gross GJ. Auchampach JA. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res. 1992;70:223-233.
37. 2+ exchange by adenosine in ewe heart sarcolemma is mediated by a pertussis toxin-sensitive G protein. J Biol Chem. 1990;265:16851-16855.
38. Rabinovitz B, Arad M, Elazar E, Klein R, Har-Zahav Y. Epicardial versus endocardial 'in mirror' changes in prostaglandin synthesis after short periods of ischemia and reperfusion. Eicosanoids. 1992;5:163-167.
39. Jugdutt BI, Grover CB, Hutchins GM, Bulkley BH, Pitt B, Becker LC. Effect of indomethacin on collateral flow and infarct size in the conscious dog. Circulation. 1997;59:734-743.