Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning

Circulation

Volumn 104, Issue 20, 2001, Pages 2453-2458

  Camitta, Michael G W ^a,b   Gabel, Scott A ^a   Chulada, Patricia ^a   Bradbury, J Alyce ^a   Langenbach, Robert ^a   Zeldin, Darryl C ^a,c   Murphy, Elizabeth ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Cyclooxygenase; Ischemia; Preconditioning; Prostaglandin; Reperfusion

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ADENOSINE TRIPHOSPHATE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INDOMETACIN; PHOSPHATE; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENZYME DEFICIENCY; ENZYME INHIBITION; HEART CONTRACTION; HEART FUNCTION; HEART INFARCTION PREVENTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; NONHUMAN; PATHOGENESIS; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0035856556     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc4401.098429     Document Type: Article

References (20)

1. Cyclooxygenases 1 and 2
2. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues
3. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
4. New look at myocardial infarction: Toward a better aspirin
5. Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases and mediated induction of cyclooxygenase-2
6. The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of bcl-2
7. Reperfusion injury induces apoptosis in rabbit cardiomyocytes
8. Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits
9. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid induced inflammation and indomethacin-induced gastric ulceration
10. Allergic lung responses are increased in PGH synthase deficient mice
11. Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1-beta
12. 2+ exchanger increases susceptibility to ischemia/reperfusion injury in male, but not female transgenic mice
13. 2 synthase are markedly affected by glutathione and glutathione peroxidase(s)
14. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
15. Correlation between cytosolic free calcium, contracture, ATP and irreversible ischemic injury in perfused rat heart
16. Protective effects of preconditioning of the ischaemic myocardium involve cyclo-oxygenase products
17. Cardioprotective effects of ischemic preconditioning are not mediated by prostanoids
18. Role of lipoxygenase metabolites in ischemic preconditioning
19. Lipid peroxidation, arachidonic acid and products of the lipoxygenase pathway in ischaemic preconditioning of the rat heart
20. Inhibition of protein synthesis does not block myocardial protection afforded by preconditioning