Pentameric procyanidin from Theobroma cacao selectively inhibits growth of human breast cancer cells

Molecular Cancer Therapeutics

Volumn 4, Issue 4, 2005, Pages 537-546

  Ramljak, Danica ^a   Romanczyk, Leo J ^b   Metheny Barlow, Linda J ^a   Thompson, Nicole ^a   Knezevic, Vladimir ^c   Galperin, Mikhail ^c   Ramesh, Arun ^c   Dickson, Robert B ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b Masterfoods USA   (United States)

^c 20/20 GeneSystems Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE 1; ESTROGEN RECEPTOR; PROCYANIDIN; PROTEIN KINASE B; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR FKHR;

APOPTOSIS; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CACAO; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL CULTURE; CELL CYCLE; CELL MEMBRANE DEPOLARIZATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DOT HYBRIDIZATION; DOWN REGULATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEOMICS; STUDENT T TEST;

ANTIOXIDANTS; BENZO(A)PYRENE; BIFLAVONOIDS; BREAST; BREAST NEOPLASMS; CATECHIN; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOBLOTTING; MALVACEAE; MEMBRANE POTENTIALS; MITOCHONDRIA; PHOSPHORYLATION; PLANT EXTRACTS; PROANTHOCYANIDINS; RECEPTORS, ESTROGEN; RETINOBLASTOMA PROTEIN; SERINE; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 18044366443     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-04-0286     Document Type: Article

References (39)

1. Funkhouser WK, Kaiser-Rogers K. Review: significance of, and optimal screening for, HER2 gene amplification and protein overexpression in breast carcinoma. Ann Clin Lab Sci 2001;31:349-58.
2. 1 checkpoint is required for E2F-induced S-phase entry. Nat Genet 2002;31:190-4.
3. Modica-Napolitano JS, Aprille JR. Basis for selective cytotoxicity of rhodamine 123. Cancer Res 1987;47:4361-5.
4. Pedersen PS, Frederiksen O, Holstein-Rathlou NH, Larsen PL, Qvortrup K. Ion transport in epithelial spheroids derived from human airway cells. Am J Physiol 1999;276:L75-80.
5. Dang CV, Lewis BC, Dolde C, Dang G, Shim H. Oncogenes in tumor metabolism, tumorigenesis, and apoptosis. J Bioenerg Biomembr 1997;29:345-54.
6. Lundholm K, Edstrom S, Karlberg I, Ekman L, Schersten T. Glucose turnover, gluconeogenesis from glycerol, and estimation of net glucose cycling in cancer patients. Cancer 1982;50:1142-50.
7. Souba WW. Glutamine and cancer. Ann Surg 1993;218:715-28.
8. Carafoli E. Mitochondria and disease. Mol Aspects Med 1980;3: 295-429.
9. Harborne JB. The flavenoids. Advances in research since 1986. Chapman & Hall; 1994.
10. Hemingway RW. Structural variations in proanthocyanidins and their derivatives. In: Hemingway RW, Karchesy JJ, editors. Chemistry and significance of condensed tannins. Plenum Publishing; 1989. p. 83-107.
11. Huan MT, Ho CT, Lee CY. Pheonolic compounds in foods and their effects on health. II. Antioxidants and cancer prevention. ACS Symposium Series 507. Washington, DC: American Chemical Society; 1992.
12. Kozikowski AP, Tuckmantel W, Bottcher G, Romanczyk LJ Jr. Studies in polyphenol chemistry and bioactivity. 4.(1) Synthesis of trimeric, tetrameric, pentameric, and higher oligomeric epicatechin-derived procyanidins having all-4,8-interflavan connectivity and their inhibition of cancer cell growth through cell cycle arrest. J Org Chem 2003;68:1641-58.
13. Ciardiello F, Gottardis M, Basolo F, et al. Additive effects of c-erbB-2, c-Ha-ras, and transforming growth factor-genes on in vitro transformation of human mammary epithelial cells. Mol Carcinog 1992;6:43-52.
14. Sheen JH, Dickson RB. Overexpression of c-Myc alters G(1)/S arrest following ionizing radiation. Mol Cell Biol 2002;22:1819-33.
15. Stampfer MR, Bartley JC. Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene. Proc Natl Acad Sci U S A 1985;82: 2394-8
16. Shaik MS, Chatterjee A, Singh M. Effects of monensin liposomes on the cytotoxicity, apoptosis and expression of multidrug resistance genes in doxorubicin-resistant human breast tumour (MCF-7/dox) cell-line. J Pharm Pharmacol 2004;56:899-907.
17. Englert CR, Baibakov GV, Emmert-Buck MR. Layered expression scanning: rapid molecular profiling of tumor samples. Cancer Res 2000;60:1526-30.
18. Galperin MM, Traicoff JL, Ramesh A, et al. Multimembrane dot-blotting: a cost-effective tool for proteome analysis. BioTechniques 2004;36:1046-51.
19. Traicoff JL, Galperin MM, Ramesh A, et al. Profiling the expression of mitogen-induced T-cell proteins by using multi-membrane dot-blotting. Biochem Biophys Res Commun 2004;323:355-60.
20. DiCioccio RA, Werness BA, Peng R, Allen HJ, Piver MS. Correlation of TP53 mutations and p53 expression in ovarian tumors. Cancer Genet Cytogenet 1998;105:93-102.
21. Galati G, Teng S, Moridani MY, Chan TS, O'Brien PJ. Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolics. Drug Metabol Drug Interact 2000;17:311-49.
22. Fantin VR, Berardi MJ, Scorrano L, Korsmeyer SJ, Leder P. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell 2002;2:29-42.
23. Fantin VR, Leder P. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res 2004;64:329-36.
24. Katdare M, Osborne MP, Telang NT. Inhibition of aberrant proliferation and induction of apoptosis in pre-neoplastic human mammary epithelial cells by natural phytochemicals. Oncol Rep 1998; 5:311-5.
25. Konishi Y, Lehtinen M, Donovan N, Bonni A. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol Cell 2002;9:1005-16.
26. Tan M, Jing T, Lan KH, et al. Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis. Mol Cell 2002; 9:993-1004.
27. Martinez-Gac L, Alvarez B, Garcia Z, et al. Phosphoinositide 3-kinase and Forkhead, a switch for cell division. Biochem Soc Trans 2004;32:360-1.
28. Jackson JG, Kreisberg JI, Koterba AP, Yee D, Brattain MG. Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment inhuman breast cancer cells. Oncogene 2000;19:4574-81.
29. Nakamura N, Ramaswamy S, Vazquez F, et al. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol 2000;20:8969-82.
30. Dijkers PF, Medema RH, Pals C, et al. Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1). Mol Cell Biol 2000;20:9138-48.
31. Keller DM, Zeng X, Wang Y, et al. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Mol Cell 2001;7:283-92.
32. Fiscella M, Zambrano N, Ullrich SJ, et al. The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities. Oncogene 1994;9:3249-57.
33. Minamoto T, Buschmann T, Habelhah H, et al. Distinct pattern of p53 phosphorylation in human tumors. Oncogene 2001;20:3341-7.
34. Furihata M, Kurabayashl A, Matsumoto M, et al. Frequent phosphorylation at serine 392 in overexpressed p53 protein due to missense mutation in carcinoma of the urinary tract. J Pathol 2002; 197:82-8.
35. Kitagawa M, Higashi H, Jung HK, et al. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J 1996;15:7060-9.
36. Panigone S, Debernardi S, Taya Y, et al. pRb and Cdk regulation by N-(4-hydroxyphenyl)retinamide. Oncogene 2000;19:4035-41.
37. Hu X, Cress WD, Zhong Q, Zuckerman KS. Transforming growth factor inhibits the phosphorylation of pRB at multiple serine/threonine sites and differentially regulates the formation of pRB family-E2F complexes in human myeloid leukemia cells. Biochem Biophys Res Commun 2000;276:930-9.
38. Dimberg A, Bahram F, Karlberg I, et al. Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p27(Kip1). Blood 2002;99:2199-206.
39. Dumont P, Leu JI, Della Pietra AC 3rd, George DL, Murphy M. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet 2003;33:357-65.