Potent anti-tumor effects of an active site mutant of human manganese-superoxide dismutase: Evolutionary conservation of product inhibition

Journal of Biological Chemistry

Volumn 279, Issue 13, 2004, Pages 12769-12776

  Davis, Christopher A ^b,c   Hearn, Amy S ^a,c   Fletcher, Bradley ^a,b,c   Bickford, Justin ^a,c   Garcia, Jorge E ^a   Leveque, Vincent ^b   Melendez, J Andres ^d   Silverman, David N ^b   Zucali, James ^a,c   Agarwal, Anupam ^a   Nick, Harry S ^a,b,c  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

^d ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; ENZYME INHIBITION; ENZYMES; TUMORS;

MUTANTS; SUPEROXIDES;

BIOCHEMISTRY;

HYDROGEN PEROXIDE; MANGANESE SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

AEROBIC METABOLISM; ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPLEX FORMATION; CYTOKINE RELEASE; ENZYME ACTIVE SITE; ENZYME MECHANISM; GENE MUTATION; GENE OVEREXPRESSION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; NEGATIVE FEEDBACK; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RESPIRATORY CHAIN; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIOXIDANTS; BINDING SITES; BLOTTING, NORTHERN; CATALASE; CATALYSIS; CELL DIVISION; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DNA, COMPLEMENTARY; EVOLUTION, MOLECULAR; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HISTIDINE; HUMANS; HYDROGEN PEROXIDE; IMMUNOBLOTTING; LUMINESCENT PROTEINS; MICE; MICE, SCID; MITOCHONDRIA; MODELS, CHEMICAL; MODELS, GENETIC; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXYGEN; PHYLOGENY; PLASMIDS; RETROVIRIDAE; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; TIME FACTORS; TRANSFECTION;

EID: 11144354714     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M310623200     Document Type: Article

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