Metabolic stabilization of benzylidene ketal M2 muscarinic receptor antagonists via halonaphthoic acid substitution

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 17, 2001, Pages 2311-2314

  Boyle, Craig D ^a   Chackalamannil, Samuel ^a   Clader, John W ^a   Greenlee, William J ^a   Josien, Hubert B ^a   Kaminski, James J ^a   Kozlowski, Joseph A ^a   McCombie, Stuart W ^a   Nazareno, Dennis V ^a   Tagat, Jayaram R ^a   Wang, Yuguang ^a   Zhou, Guowei ^a   Billard, William ^a   Binch III, Herbert ^a   Crosby, Gordon ^a   Cohen Williams, Mary ^a   Coffin, Vicki L ^a   Cox, Kathleen A ^a   Grotz, Diane E ^a   Duffy, Ruth A ^a   Ruperto, Vilma ^a   Lachowicz, Jean E ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BENZODIOXOLE DERIVATIVE; 4 FLUORONAPHTHAMIDE; ACETAL DERIVATIVE; ACID; BENZYLIDENE DERIVATIVE; HALIDE; MEQUINOL; MUSCARINIC M2 RECEPTOR; MUSCARINIC M2 RECEPTOR ANTAGONIST; NAPHTHALENE DERIVATIVE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG STABILITY; DRUG STRUCTURE; METABOLIC INHIBITION; MICROSOME; NONHUMAN; PRIMATE; RAT; RECEPTOR AFFINITY; RECEPTOR SENSITIVITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TOXICOLOGICAL PARAMETERS;

ACETYLCHOLINE; ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BENZYLIDENE COMPOUNDS; CYTOCHROME P-450 ENZYME SYSTEM; DIOXOLES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; HUMANS; MACACA FASCICULARIS; MICRODIALYSIS; MICROSOMES, LIVER; MUSCARINIC ANTAGONISTS; RATS; RECEPTOR, MUSCARINIC M2; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 17944374338     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00435-8     Document Type: Article

References (32)