Design and synthesis of ether analogues as potent and selective M2 muscarinic receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 7, 2001, Pages 891-894

  Wang, Yuguang ^a   Chackalamannil, Samuel ^a   Chang, Wei ^a   Greenlee, William ^a   Ruperto, Vilma ^a   Duffy, Ruth A ^a   McQuade, Robert ^a   Lachowicz, Jean E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYL ETHER; DIPHENYL ETHER; ETHER DERIVATIVE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M2 RECEPTOR ANTAGONIST; STYRENE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINE; ALKENES; DRUG DESIGN; ETHER, ETHYL; HUMANS; MUSCARINIC ANTAGONISTS; PROTEIN BINDING; RECEPTOR, MUSCARINIC M1; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; RECEPTOR, MUSCARINIC M5; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035832102     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00100-7     Document Type: Article

References (17)