Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 20, 2000, Pages 2247-2250

  Wang, Yuguang ^a   Chackalamannil, Samuel ^a   Hu, Zhiyong ^a   Clader, John W ^a   Greenlee, William ^a   Billard, William ^a   Binch III, Herbert ^a   Crosby, Gordon ^a   Ruperto, Vilma ^a   Duffy, Ruth A ^a   McQuade, Robert ^a   Lachowicz, Jean E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUSCARINIC M2 RECEPTOR ANTAGONIST; PIPERIDINE DERIVATIVE;

ACETYLCHOLINE RELEASE; ALZHEIMER DISEASE; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; RAT;

ACETYLCHOLINE; ADMINISTRATION, ORAL; ANIMAL; BRAIN; DRUG DESIGN; MICRODIALYSIS; MUSCARINIC ANTAGONISTS; PIPERIDINES; RATS; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034675702     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00457-1     Document Type: Article

References (19)