Single and interacting QTLs for cholesterol gallstones revealed in an intercross between mouse strains NZB and SM

Mammalian Genome

Volumn 16, Issue 3, 2005, Pages 152-163

  Lyons, Malcolm A ^a,b   Korstanje, Ron ^a   Li, Renhua ^b   Sheehan, Susan M ^a   Walsh, Kenneth A ^a   Rollins, Jarod A ^a   Carey, Martin C ^c   Paigen, Beverly ^a   Churchill, Gary A ^a  

^a JACKSON LABORATORY   (United States)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; MESSENGER RNA;

AMINO ACID ANALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL STONE; CHROMOSOME ANALYSIS; CONTROLLED STUDY; FEMALE; GENETIC CORRELATION; GENETIC EPISTASIS; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; HAPLOTYPE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PHENOTYPIC VARIATION; PROTEIN EXPRESSION; QUANTITATIVE TRAIT LOCUS; QUANTITATIVE TRAIT LOCUS MAPPING; RNA ANALYSIS; STRAIN DIFFERENCE; WEIGHT;

ANIMALS; CHOLELITHIASIS; CHOLESTEROL; CROSSES, GENETIC; FEMALE; MALE; MICE; MICE, INBRED NZB; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; PHENOTYPE; QUANTITATIVE TRAIT LOCI; SYMPORTERS;

EID: 17644375869     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00335-004-2446-5     Document Type: Article

References (31)

1. G Bouchard D Johnson T Carver MC Carey B Paigen 2001 Multiple new murine models of cholesterol gallstones (ChGS): The Jackson Laboratory-Brigham and Women's Hospital strain survey Gastroenterology 120 A72 (abstract)
2. KW Broman 2003 Mapping quantitative trait loci in the case of a spike in the phenotype distribution Genetics 163 1169 1175
3. GA Churchill RW Doerge 1994 Empirical threshold values for quantitative trait mapping Genetics 138 963 971
4. L Flaherty Complex Trait Consortium 2003 The nature and identification of quantitative trait loci: a community's view Nat Rev Genet 4 911 916
5. C Galman JF Miquel RM Perez C Einarsson L Stahle 2004 Bile acid synthesis is increased in Chilean Hispanics with gallstones and in gallstone highrisk Mapuche Indians Gastroenterology 126 741 748
6. SM Grundy AL Metzger RD Adler 1972 Mechanisms of lithogenic bile formation in American Indian women with cholesterol gallstones J Clin Invest 51 3026 3043
7. B Khanuja YC Cheah M Hunt PM Nishina DQH Wang 1995 Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice Proc Natl Acad Sci USA 92 7729 7733
8. R Korstanje JJ Albers G Wolfbauer R Li AY Tu 2004a Quantitative trait locus mapping of genes that regulate phospholipid transfer activity in SM/J and NZB/B1NJ inbred mice Arterioscler Thromb Vasc Biol 24 155 160
9. R Korstanje R Li T Howard P Kelmenson J Marshall 2004b Influence of sex and diet on quantitative trait loci for HDLcholesterol levels in a SM/J by NZB/B1NJ intercross population J Lipid Res 45 881 888
10. F Lammert DQH Wang DE Cohen B Paigen MC Carey 1999 Functional and genetic studies of biliary cholesterol secretion in inbred mice: evidence for a primary role of sister to Pglycoprotein, the canalicular bile salt export pump, in cholesterol gallstone pathogenesis G Paumgartner A Stiehl D Keppler W Gerok U Leuschner Falk Symposium 108: Bile Acids and Cholestasis Kluwer Academic Publishers Dordrecht 224 228
11. F Lammert DQ Wang H Wittenburg G Bouchard S Hillebrandt 2002 Lith genes control mucin accumulation, cholesterol crystallization, and gallstone formation in A/J and AKR/J inbred mice Hepatology 36 1145 1154
12. MA Lyons H Wittenburg R Li K Walsh GA Churchill 2003a Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice J Lipid Res 44 953 967
13. MA Lyons H Wittenburg R Li K Walsh MR Leonard 2003b New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 12981/SvImJ inbred mice Physiol Genomics 14 225 239
14. MA Lyons H Wittenburg R Li K Walsh MR Leonard 2003c Lith6: A New QTL cholesterol gallstones from an intercross of CAST/Ei and DBA/2J inbred mouse strains J Lipid Res 44 1763 1771
15. MA Lyons H Wittenburg R Li KA Walsh R Korstanje 2004 Quantitative trait loci that determine lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and CAST/Ei inbred mice Physiol Genomics 17 60 68
16. D Machleder B Ivandic C Welch L Castellani K Reue 1997 Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism J Clin Invest 99 1406 1419
17. A Mamianetti D Garrido CN Carducci MC Vescina 1999 Fecal bile acid excretion profile in gallstone patients Medicina (B Aires) 59 269 273
18. KJ Moore DL Nagle 2000 Complex trait analysis in the mouse: The strengths, the limitations and the promise yet to come Annu Rev Genet 34 653 686
19. B Paigen MC Carey 2002 Gallstone RA King JI Rotter AG Motulsky The genetic basis of common diseases Oxford University Press New York 298 335
20. B Paigen NJ Schork KL Svenson YC Cheah JL Mu 2000 Quantitative trait loci mapping for cholesterol gallstones in AKR/J and C57L/J strains of mice Physiol Genomics 4 59 65
21. WA Pitman MH Hunt C McFarland B Paigen 1998 Genetic analysis of the difference in dietinduced atherosclerosis between the inbred mouse strains SM/J and NZB/B1NJ Arterioscler Thromb Vasc Biol 18 615 620
22. WA Pitman R Korstanje GA Churchill E Nicodeme JJ Albers 2002 Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice Physiol Genomics 9 93 102
23. RS Sandler JE Everhart M Donowitz E Adams K Cronin 2002 The burden of selected digestive diseases in the United States Gastroenterology 122 1500 1511
24. S Sen GA Churchill 2001 A statistical framework for quantitative trait mapping Genetics 159 371 387
25. F Sugiyama GA Churchill DC Higgins C Johns KP Makaritsis 2001 Concordance of murine quantitative trait loci for saltinduced hypertension with rat and human loci Genomics 71 70 77
26. JD Thompson DG Higgins TJ Gibson 1994 CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positionspecific gap penalties and weight matrix choice Nucleic Acids Res 22 4673 4680
27. DQH Wang B Paigen MC Carey 1997 Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: physicalchemistry of gallbladder bile J Lipid Res 38 1395 1411
28. X Wang R Korstanje D Higgins B Paigen 2004 Haplotypes analysis in multiple crosses to identify a QTL gene Genome Res 14 1767 1772
29. H Wittenburg F Lammert DQ Wang GA Churchill R Li 2002 Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of mice Physiol Genomics 8 67 77
30. H Wittenburg MA Lyons R Li GA Churchill MC Carey B Paigen 2003a FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice Gastroenterology 125 868 881
31. H Wittenburg MA Lyons B Paigen MC Carey 2003b Mapping cholesterol gallstone susceptibility (Lith) Genes in inbred mice Dig Liver Dis 35 S2 S7