Synthesis and biological evaluation of α- and γ-carboxamide derivatives of 10-CF3CO-DDACTHF

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 10, 2005, Pages 3587-3592

  Chong, Youhoon ^a   Hwang, Inkyu ^a   Tavassoli, Ali ^b   Zhang, Yan ^a   Wilson, Ian A ^a   Benkovic, Stephen J ^b   Boger, Dale L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10 TRIFLUOROACETYL 5,10 DIDEAZA ACYCLIC 5,6,7,8 TETRAHYDROFOLIC ACID; 4 CARBAMOYL 2 [4 [4 (2,4 DIAMINO 6 OXO 1,6 DIHYDROPYRIMIDIN 5 YL) 1 (2,2,2 TRIFLUOROACETYL)BUTYL]BENZOYLAMINO]BUTYRIC ACID; 4 CARBAMOYL 4 [4 [4 (2,4 DIAMINO 6 OXO 1,6 DIHYDROPYRIMIDIN 5 YL) 1 (2,2,2 TRIFLUOROACETYL)BUTYL]BENZOYLAMINO]BUTYRIC ACID; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; FLUORINE DERIVATIVE; GLUTAMINE; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; RECOMBINANT ENZYME; RECOMBINANT GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE; UNCLASSIFIED DRUG;

ARTICLE; CELL ASSAY; CELL LINE; CELL TRANSPORT; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; PURINE SYNTHESIS; SENSITIVITY ANALYSIS; STRUCTURE ANALYSIS;

EID: 17444383044     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.11.050     Document Type: Article

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