Synthesis and biological evaluation of DL-4,4-difluoroglutamic acid and DL-γ,γ-difluoromethotrexate

Journal of Medicinal Chemistry

Volumn 39, Issue 1, 1996, Pages 66-72

  Tsukamoto, Takashi ^a,b   Kitazume, Tomoya ^b   McGuire, John J ^c   Coward, James K ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4 DIFLUOROGLUTAMIC ACID; FOLIC ACID; FOLIC ACID ANTAGONIST; GAMMA,GAMMA DIFLUOROMETHOTREXATE; METHOTREXATE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CELL GROWTH; DRUG ACTIVITY; DRUG SYNTHESIS; STEREOSPECIFICITY;

AMINOPTERIN; CELL DIVISION; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FOLIC ACID ANTAGONISTS; GLUTAMATES; GLUTAMIC ACID; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; METHOTREXATE; MOLECULAR STRUCTURE; PEPTIDE SYNTHASES; TETRAHYDROFOLATE DEHYDROGENASE; TUMOR CELLS, CULTURED;

EID: 0030052336     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950514m     Document Type: Article

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