A new class of selective myocardial calcium channel modulators. 2. Role of the acetal chain in oxadiazol-3-one derivatives

Journal of Medicinal Chemistry

Volumn 48, Issue 7, 2005, Pages 2445-2456

  Budriesi, Roberta ^a   Carosati, Emanuele ^b   Chiarini, Alberto ^a   Cosimelli, Barbara ^c   Cruciani, Gabriele ^b   Ioan, Pierfranco ^a   Spinelli, Domenico ^a   Spisani, Raffaella ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

8 (4 BROMOPHENYL) 8 METHOXY 5 METHYL 8H [1,4]THIAZINO[3,4 C][1,2,4]OXADIAZOL 3 ONE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 8 HYDROXY 5 METHYL 8H [1,4]THIAZINO[3,4 C][1,2,4]OXADIAZOL 3 ONE; 8 HYDROXY 8H [1,4]THIAZINO[3,4 C][1,2,4]OXADIAZOL 3 ONE; ACETAL; ADENOSINE RECEPTOR BLOCKING AGENT; ATROPINE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; DILTIAZEM; MUSCARINIC RECEPTOR BLOCKING AGENT; OXADIAZOL 3 ONE DERIVATIVE; OXADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; HEART LEFT ATRIUM; HEART PAPILLARY MUSCLE; INOTROPISM; MOLECULAR MODEL; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; THORACIC AORTA;

ACETALS; ANIMALS; AORTA, THORACIC; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; DEPRESSION, CHEMICAL; FEMALE; GUINEA PIGS; HEART; HEART RATE; MODELS, MOLECULAR; MUSCLE, SMOOTH, VASCULAR; MYOCARDIAL CONTRACTION; MYOCARDIUM; OXADIAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17144392908     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0493414     Document Type: Article

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