Cardiovascular characterization of [1,4]thiazino[3,4-c][1,2,4]oxadiazol-1-one derivatives: Selective myocardial calcium channel modulators

Journal of Medicinal Chemistry

Volumn 45, Issue 16, 2002, Pages 3475-3481

  Budriesi, Roberta ^a   Cosimelli, Barbara ^a   Ioan, Pierfranco ^a   Lanza, Camilla Zaira ^a   Spinelli, Domenico ^a   Chiarini, Alberto ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

8 (4 CHLOROPHENYL) 8 (2 METHYLPROPOXY) 5 METHYL 8H [1,4]THIAZINO[3,4 C][1,2,4]OXADIAZOL 3 ONE; 8 (4 CHLOROPHENYL) 8 METHOXY 4 METHYL 8H [1,4]THIAZINO[3,4 C][1,2,4]OXADIAZOL 3 ONE; 8 HYDROXY 8 PHENYL 8H [1,4]THIAZINO[3,4 C][1,2,4]OXADIAZOL 3 ONE; [1,4]THIAZINO[3,4 C][1,2,4]OXADIAZOL 1 ONE DERIVATIVE; CALCIUM CHANNEL; CALCIUM CHANNEL AFFECTING AGENT; DILTIAZEM; OXADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

AB INITIO CALCULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CALCIUM TRANSPORT; CARDIOVASCULAR RESPONSE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HEART LEFT ATRIUM; HEART MUSCLE CELL; HEART RIGHT ATRIUM; INOTROPISM; NONHUMAN; POLYMERIZATION; POTASSIUM TRANSPORT; STRUCTURE ACTIVITY RELATION; TISSUE CULTURE;

ANIMALS; AORTA, THORACIC; ATRIAL FUNCTION; CALCIUM CHANNELS; CARDIOVASCULAR AGENTS; DEPRESSION, CHEMICAL; FEMALE; GUINEA PIGS; HEART ATRIA; MOLECULAR STRUCTURE; MYOCARDIAL CONTRACTION; MYOCARDIUM; OXADIAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZINES; VASODILATOR AGENTS;

EID: 0036682190     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020815d     Document Type: Article

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