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Volumn 77, Issue 4, 2005, Pages 496-502

Inducible immune regulation following autoimmune disease in the immune-privileged eye

Author keywords

Ocular immunity; Regulatory T cells

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; RETINA ANTIGEN;

EID: 16844379160     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0204114     Document Type: Article
Times cited : (61)

References (52)
  • 1
    • 0242636366 scopus 로고    scopus 로고
    • Ocular immune privilege: Therapeutic opportunities from an experiment of nature
    • Streilein, J. W. (2003) Ocular immune privilege: therapeutic opportunities from an experiment of nature. Nat. Rev. Immunol. 3, 879-889.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 879-889
    • Streilein, J.W.1
  • 2
    • 0348140680 scopus 로고    scopus 로고
    • A review of the influence of aqueous humor on immunity
    • Taylor, A. (2003) A review of the influence of aqueous humor on immunity. Ocul. Immunol. Inflamm. 11, 231-241.
    • (2003) Ocul. Immunol. Inflamm. , vol.11 , pp. 231-241
    • Taylor, A.1
  • 5
    • 0038125664 scopus 로고    scopus 로고
    • Participation of pigment epithelium in ocular immune privilege. 3. Epithelia cultured from iris, ciliary body, and retina suppress T-cell activation by partially non-overlapping mechanisms
    • Ishida, K., Panjwani, N., Cao, Z., Streilein, J. W. (2003) Participation of pigment epithelium in ocular immune privilege. 3. Epithelia cultured from iris, ciliary body, and retina suppress T-cell activation by partially non-overlapping mechanisms. Ocul. Immunol. Inflamm. 11, 91-105.
    • (2003) Ocul. Immunol. Inflamm. , vol.11 , pp. 91-105
    • Ishida, K.1    Panjwani, N.2    Cao, Z.3    Streilein, J.W.4
  • 6
    • 0034055525 scopus 로고    scopus 로고
    • Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 1. Inhibition of T-cell activation in vitro by direct cell-to-cell conlact
    • Yoshida, M., Takeuchi, M., Streilein, J. W. (2000) Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 1. Inhibition of T-cell activation in vitro by direct cell-to-cell conlact. Invest. Ophthalmol. Vis. Sci. 41, 811-821.
    • (2000) Invest. Ophthalmol. Vis. Sci. , vol.41 , pp. 811-821
    • Yoshida, M.1    Takeuchi, M.2    Streilein, J.W.3
  • 7
    • 0036190186 scopus 로고    scopus 로고
    • Role of Fas ligand in ocular tissue
    • Sano, Y., Sotozono, C. (2002) Role of Fas ligand in ocular tissue. Cornea 21, S30-S32.
    • (2002) Cornea , vol.21
    • Sano, Y.1    Sotozono, C.2
  • 9
    • 0026055359 scopus 로고
    • Identification of transforming growth factor-β as an immunosuppressive factor in aqueous humor
    • Cousins, S. W., McCabe, M. M., Danielpour, D., Streilein, J. W. (1991) Identification of transforming growth factor-β as an immunosuppressive factor in aqueous humor. Invest. Ophthalmol. Vis. Sci. 32, 2201-2211.
    • (1991) Invest. Ophthalmol. Vis. Sci. , vol.32 , pp. 2201-2211
    • Cousins, S.W.1    McCabe, M.M.2    Danielpour, D.3    Streilein, J.W.4
  • 10
    • 0026605081 scopus 로고
    • Fluids from immune privileged sites endow macrophages with the capacity to induce antigen-specific immune deviation via a mechanism involving transforming growth factor-β
    • Wilbanks, G. A., Streilein, J. W. (1992) Fluids from immune privileged sites endow macrophages with the capacity to induce antigen-specific immune deviation via a mechanism involving transforming growth factor-β. Eur. J. Immunol. 22, 1031-1036.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 1031-1036
    • Wilbanks, G.A.1    Streilein, J.W.2
  • 11
    • 0025791004 scopus 로고
    • Studies on the induction of anterior chamber-associated immune deviation (ACAID). I. Evidence that an antigen-specific, ACAID-inducing, cell-associated signal exists in the peripheral blood
    • Wilbanks, G. A., Streilein, J. W. (1991) Studies on the induction of anterior chamber-associated immune deviation (ACAID). I. Evidence that an antigen-specific, ACAID-inducing, cell-associated signal exists in the peripheral blood. J. Immunol. 146, 2610-2617.
    • (1991) J. Immunol. , vol.146 , pp. 2610-2617
    • Wilbanks, G.A.1    Streilein, J.W.2
  • 12
    • 0025892477 scopus 로고
    • Studies on the induction of anterior chamber-associated immune deviation (ACAID). II. Eye-derived cells participate in generating blood-borne signals that induce ACAID
    • Wilbanks, G. A., Mammolenti, M., Streilein, J. W. (1991) Studies on the induction of anterior chamber-associated immune deviation (ACAID). II. Eye-derived cells participate in generating blood-borne signals that induce ACAID. J. Immunol. 146, 3018-3024.
    • (1991) J. Immunol. , vol.146 , pp. 3018-3024
    • Wilbanks, G.A.1    Mammolenti, M.2    Streilein, J.W.3
  • 13
    • 0026775061 scopus 로고
    • Macrophages capable of inducing anterior chamber associated immune deviation demonstrate spleen-seeking migratory properties
    • Wilbanks, G. A., Streilein, J. W. (1992) Macrophages capable of inducing anterior chamber associated immune deviation demonstrate spleen-seeking migratory properties. Reg. Immunol. 4, 130-137.
    • (1992) Reg. Immunol. , vol.4 , pp. 130-137
    • Wilbanks, G.A.1    Streilein, J.W.2
  • 14
    • 0036644177 scopus 로고    scopus 로고
    • + T cells to the spleen during the generation of regulatory T cells in tolerance
    • + T cells to the spleen during the generation of regulatory T cells in tolerance. J. Immunol. 169, 31-38.
    • (2002) J. Immunol. , vol.169 , pp. 31-38
    • Faunce, D.E.1    Stein-Streilein, J.2
  • 15
    • 0031661152 scopus 로고    scopus 로고
    • Splenic B cells are required for tolerogenic antigen presentation in the induction of anterior chamber-associated immune deviation (ACAID)
    • D'Orazio, T. J., Niederkorn, J. Y. (1998) Splenic B cells are required for tolerogenic antigen presentation in the induction of anterior chamber-associated immune deviation (ACAID). Immunology 95, 47-55.
    • (1998) Immunology , vol.95 , pp. 47-55
    • D'Orazio, T.J.1    Niederkorn, J.Y.2
  • 16
    • 0033230839 scopus 로고    scopus 로고
    • CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site
    • Sonoda, K. H., Exley, M., Snapper, S., Balk, S. P., Stein-Streilein, J. (1999) CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J. Exp. Med. 190, 1215-1226.
    • (1999) J. Exp. Med. , vol.190 , pp. 1215-1226
    • Sonoda, K.H.1    Exley, M.2    Snapper, S.3    Balk, S.P.4    Stein-Streilein, J.5
  • 17
    • 0021925081 scopus 로고
    • Characterization of the suppressor cell(s) responsible for anterior chamber-associated immune deviation (ACAID) induced in BALB/c mice by P815 cells
    • Streilein, J. W., Niederkorn, J. Y. (1985) Characterization of the suppressor cell(s) responsible for anterior chamber-associated immune deviation (ACAID) induced in BALB/c mice by P815 cells. J. Immunol. 134, 1381-1387.
    • (1985) J. Immunol. , vol.134 , pp. 1381-1387
    • Streilein, J.W.1    Niederkorn, J.Y.2
  • 18
    • 0035173022 scopus 로고    scopus 로고
    • Ocular immune privilege promoted by the presentation of peptide on tolerogenic B cells in the spleen. II. Evidence for presentation by Qa-1
    • D'Orazio, T. J., Mayhew, E., Niederkorn, J. Y. (2001) Ocular immune privilege promoted by the presentation of peptide on tolerogenic B cells in the spleen. II. Evidence for presentation by Qa-1. J. Immunol. 166, 26-32.
    • (2001) J. Immunol. , vol.166 , pp. 26-32
    • D'Orazio, T.J.1    Mayhew, E.2    Niederkorn, J.Y.3
  • 19
    • 0026574560 scopus 로고
    • Suppression of experimental autoimmune uveitis in mice by induction of anterior chamber-associated immune deviation with interphotoreceptor retinoid-binding protein
    • Hara, Y., Caspi, R. R., Wiggert, B., Chan, C. C., Wilbanks, G. A., Streilein, J. W. (1992) Suppression of experimental autoimmune uveitis in mice by induction of anterior chamber-associated immune deviation with interphotoreceptor retinoid-binding protein. J. Immunol. 148, 1685-1692.
    • (1992) J. Immunol. , vol.148 , pp. 1685-1692
    • Hara, Y.1    Caspi, R.R.2    Wiggert, B.3    Chan, C.C.4    Wilbanks, G.A.5    Streilein, J.W.6
  • 20
    • 0026672303 scopus 로고
    • Analysis of an in vitro-generated signal that induces systemic immune deviation similar to that elicited by antigen injected into the anterior chamber of the eye
    • Hara, Y., Caspi, R. R., Wiggert, B., Dorf, M., Streilein, J. W. (1992) Analysis of an in vitro-generated signal that induces systemic immune deviation similar to that elicited by antigen injected into the anterior chamber of the eye. J. Immunol. 149, 1531-1538.
    • (1992) J. Immunol. , vol.149 , pp. 1531-1538
    • Hara, Y.1    Caspi, R.R.2    Wiggert, B.3    Dorf, M.4    Streilein, J.W.5
  • 21
    • 0033764314 scopus 로고    scopus 로고
    • Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 2. Generation of TGF-β-producing regulatory T cells
    • Yoshida, M., Kezuka, T., Streilein, J. W. (2000) Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 2. Generation of TGF-β-producing regulatory T cells. Invest. Ophthalmol. Vis. Sci. 41, 3862-3870.
    • (2000) Invest. Ophthalmol. Vis. Sci. , vol.41 , pp. 3862-3870
    • Yoshida, M.1    Kezuka, T.2    Streilein, J.W.3
  • 22
    • 0030886870 scopus 로고    scopus 로고
    • Aqueous humor induces transforming growth factor-β (TGF-β)-producing regulatory T-cells
    • Taylor, A. W., Alard, P., Yee, D. G., Streilein, J. W. (1997) Aqueous humor induces transforming growth factor-β (TGF-β)-producing regulatory T-cells. Curr. Eye Res. 16, 900-908.
    • (1997) Curr. Eye Res. , vol.16 , pp. 900-908
    • Taylor, A.W.1    Alard, P.2    Yee, D.G.3    Streilein, J.W.4
  • 23
    • 0032862496 scopus 로고    scopus 로고
    • Specific aqueous humor factors induce activation of regulatory T cells
    • Nishida, T., Taylor, A. W. (1999) Specific aqueous humor factors induce activation of regulatory T cells. Invest. Ophthalmol. Vis. Sci. 40, 2268-2274.
    • (1999) Invest. Ophthalmol. Vis. Sci. , vol.40 , pp. 2268-2274
    • Nishida, T.1    Taylor, A.W.2
  • 24
    • 0034891246 scopus 로고    scopus 로고
    • + regulatory T cells by the neuropeptide α-melanocyte stimulating hormone (α-MSH)
    • + regulatory T cells by the neuropeptide α-melanocyte stimulating hormone (α-MSH). Immunol. Cell Biol. 79, 358-367.
    • (2001) Immunol. Cell Biol. , vol.79 , pp. 358-367
    • Taylor, A.1    Namba, K.2
  • 25
    • 0036851922 scopus 로고    scopus 로고
    • Induction of regulatory T cells by the immunomodulating cytokines α-melanocyte-stimulating hormone and transforming growth factor-β2
    • Namba, K., Kitaichi, N., Nishida, T., Taylor, A. W. (2002) Induction of regulatory T cells by the immunomodulating cytokines α-melanocyte- stimulating hormone and transforming growth factor-β2. J. Leukoc. Biol. 72, 946-952.
    • (2002) J. Leukoc. Biol. , vol.72 , pp. 946-952
    • Namba, K.1    Kitaichi, N.2    Nishida, T.3    Taylor, A.W.4
  • 26
    • 0041850024 scopus 로고    scopus 로고
    • Ocular immune privilege: The eye takes a dim but practical view of immunity and inflammation
    • Streilein, J. W. (2003) Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation. J. Leukoc. Biol. 74, 179-185.
    • (2003) J. Leukoc. Biol. , vol.74 , pp. 179-185
    • Streilein, J.W.1
  • 28
    • 0036732961 scopus 로고    scopus 로고
    • A relationship between varicella-zoster virus-specific delayed hypersensitivity and varicella-zoster virus-induced anterior uveitis
    • Kezuka, T., Sakai, J., Minoda, H., Takeuchi, M., Keino, H., Streilein, J. W., Usui, M. (2002) A relationship between varicella-zoster virus-specific delayed hypersensitivity and varicella-zoster virus-induced anterior uveitis. Arch. Ophthalmol. 120, 1183-1188.
    • (2002) Arch. Ophthalmol. , vol.120 , pp. 1183-1188
    • Kezuka, T.1    Sakai, J.2    Minoda, H.3    Takeuchi, M.4    Keino, H.5    Streilein, J.W.6    Usui, M.7
  • 32
    • 0023912944 scopus 로고
    • A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens
    • Caspi, R. R., Roberge, F. G., Chan, C. C., Wiggert, B., Chader, G. J., Rozenszajn, L. A., Lando, Z., Nussenblatt, R. B. (1988) A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J. Immunol. 140, 1490-1495.
    • (1988) J. Immunol. , vol.140 , pp. 1490-1495
    • Caspi, R.R.1    Roberge, F.G.2    Chan, C.C.3    Wiggert, B.4    Chader, G.J.5    Rozenszajn, L.A.6    Lando, Z.7    Nussenblatt, R.B.8
  • 33
    • 0033665323 scopus 로고    scopus 로고
    • Neuropeptide regulation of immunity. The immunosuppressive activity of α-melanocyte-stimulating hormone (α-MSH)
    • Taylor, A. W., Yee, D. G., Nishida, T., Namba, K. (2000) Neuropeptide regulation of immunity. The immunosuppressive activity of α-melanocyte- stimulating hormone (α-MSH). Ann. N. Y. Acad. Sci. 917, 239-247.
    • (2000) Ann. N. Y. Acad. Sci. , vol.917 , pp. 239-247
    • Taylor, A.W.1    Yee, D.G.2    Nishida, T.3    Namba, K.4
  • 34
    • 0025224743 scopus 로고
    • Characterization of suppressor cells in anterior chamber-associated immune deviation (ACAID) induced by soluble antigen. Evidence of two functionally and phenotypically distinct T-suppressor cell populations
    • Wilbanks, G. A., Streilein, J. W. (1990) Characterization of suppressor cells in anterior chamber-associated immune deviation (ACAID) induced by soluble antigen. Evidence of two functionally and phenotypically distinct T-suppressor cell populations. Immunology 71, 383-389.
    • (1990) Immunology , vol.71 , pp. 383-389
    • Wilbanks, G.A.1    Streilein, J.W.2
  • 35
    • 0032030582 scopus 로고    scopus 로고
    • A novel role for TGF-β and IL-10 in the induction of immune privilege
    • D'Orazio, T. J., Niederkorn, J. Y. (1998) A novel role for TGF-β and IL-10 in the induction of immune privilege. J. Immunol. 160, 2089-2098.
    • (1998) J. Immunol. , vol.160 , pp. 2089-2098
    • D'Orazio, T.J.1    Niederkorn, J.Y.2
  • 36
    • 0036201875 scopus 로고    scopus 로고
    • CD1d on antigen-transporting APC and splenic marginal zone B cells promotes NKT cell-dependent tolerance
    • Sonoda, K. H., Stein-Streilein, J. (2002) CD1d on antigen-transporting APC and splenic marginal zone B cells promotes NKT cell-dependent tolerance. Eur. J. Immunol. 32, 848-857.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 848-857
    • Sonoda, K.H.1    Stein-Streilein, J.2
  • 37
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmmunity
    • Shevach, E. M. (2000) Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 18, 423-449.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 423-449
    • Shevach, E.M.1
  • 38
    • 0036730884 scopus 로고    scopus 로고
    • Spontaneous induction of immunoregulation by an endogenous retinal antigen
    • Gregerson, D. S., Don, C. (2002) Spontaneous induction of immunoregulation by an endogenous retinal antigen. Invest. Ophthalmol. Vis. Sci. 43, 2984-2991.
    • (2002) Invest. Ophthalmol. Vis. Sci. , vol.43 , pp. 2984-2991
    • Gregerson, D.S.1    Don, C.2
  • 40
    • 0015958982 scopus 로고
    • Immuno-regulatory role of spleen localizing thymocytes
    • Gershon, R. K., Lance, E. M., Kondo, K. (1974) Immuno-regulatory role of spleen localizing thymocytes. J. Immunol. 112, 546-554.
    • (1974) J. Immunol. , vol.112 , pp. 546-554
    • Gershon, R.K.1    Lance, E.M.2    Kondo, K.3
  • 41
    • 0033437179 scopus 로고    scopus 로고
    • Anterior chamber-associated immune deviation-inducing cells activate T cells, and rescue them from antigen-induced apoptosis
    • Takeuchi, M., Alard, P., Verbik, D., Ksander, B., Streilein, J. W. (1999) Anterior chamber-associated immune deviation-inducing cells activate T cells, and rescue them from antigen-induced apoptosis. Immunology 98, 576-583.
    • (1999) Immunology , vol.98 , pp. 576-583
    • Takeuchi, M.1    Alard, P.2    Verbik, D.3    Ksander, B.4    Streilein, J.W.5
  • 42
    • 0032519412 scopus 로고    scopus 로고
    • TGF-β promotes immune deviation by altering accessory signals of antigen-presenting cells
    • Takeuchi, M., Alard, P., Streilein, J. W. (1998) TGF-β promotes immune deviation by altering accessory signals of antigen-presenting cells. J. Immunol. 160, 1589-1597.
    • (1998) J. Immunol. , vol.160 , pp. 1589-1597
    • Takeuchi, M.1    Alard, P.2    Streilein, J.W.3
  • 43
    • 2242493413 scopus 로고    scopus 로고
    • Peripheral expression of ocular antigens in regulation and therapy of ocular autoimmunity
    • Gregerson, D. S. (2002) Peripheral expression of ocular antigens in regulation and therapy of ocular autoimmunity. Int. Rev. Immunol. 21, 101-121.
    • (2002) Int. Rev. Immunol. , vol.21 , pp. 101-121
    • Gregerson, D.S.1
  • 44
    • 0017734968 scopus 로고
    • Immunologically privileged sites
    • Barker, C. F., Billingham, R. E. (1977) Immunologically privileged sites. Adv. Immunol. 25, 1-54.
    • (1977) Adv. Immunol. , vol.25 , pp. 1-54
    • Barker, C.F.1    Billingham, R.E.2
  • 45
    • 78651010946 scopus 로고
    • Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain to subcutaneous tissue, and to the anterior chamber of the eye
    • Medawar, P. (1948) Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain to subcutaneous tissue, and to the anterior chamber of the eye. Br. J. Exp. Pathol. 29, 58-69.
    • (1948) Br. J. Exp. Pathol. , vol.29 , pp. 58-69
    • Medawar, P.1
  • 46
    • 0033565592 scopus 로고    scopus 로고
    • Retinal expression of a neo-self antigen, β-galactosidase, is not tolerogenic and creates a target for autoimmune uveoretinitis
    • Gregerson, D. S., Torseth, J. W., McPherson, S. W., Roberts, J. P., Shinohara, T., Zack, D. J. (1999) Retinal expression of a neo-self antigen, β-galactosidase, is not tolerogenic and creates a target for autoimmune uveoretinitis. J. Immunol. 163, 1073-1080.
    • (1999) J. Immunol. , vol.163 , pp. 1073-1080
    • Gregerson, D.S.1    Torseth, J.W.2    McPherson, S.W.3    Roberts, J.P.4    Shinohara, T.5    Zack, D.J.6
  • 47
    • 0017709840 scopus 로고
    • Evidence for suppressor cells in Lewis rats' experimental allergic encephalomyelitis
    • Adda, D. H., Beraud, E., Depieds, R. (1977) Evidence for suppressor cells in Lewis rats' experimental allergic encephalomyelitis. Eur. J. Immunol. 7, 620-623.
    • (1977) Eur. J. Immunol. , vol.7 , pp. 620-623
    • Adda, D.H.1    Beraud, E.2    Depieds, R.3
  • 48
    • 0033231445 scopus 로고    scopus 로고
    • Regulatory T cells in experimental allergic encephalomyelitis. II. T cells functionally antagonistic to encephalitogemic MBP-specific T cells show persistent expression of FasL
    • Sun, D., Whitaker, J. N., Wilson, D. B. (1999) Regulatory T cells in experimental allergic encephalomyelitis. II. T cells functionally antagonistic to encephalitogemic MBP-specific T cells show persistent expression of FasL. J. Neurosci. Res. 58, 357-366.
    • (1999) J. Neurosci. Res. , vol.58 , pp. 357-366
    • Sun, D.1    Whitaker, J.N.2    Wilson, D.B.3
  • 49
    • 0023841943 scopus 로고
    • A suppressor T-lymphocyte cell line for autoimmune encephalomyelitis
    • Ellerman, K. E., Powers, J. M., Brostoff, S. W. (1988) A suppressor T-lymphocyte cell line for autoimmune encephalomyelitis. Nature 331, 265-267.
    • (1988) Nature , vol.331 , pp. 265-267
    • Ellerman, K.E.1    Powers, J.M.2    Brostoff, S.W.3
  • 50
    • 0020463170 scopus 로고
    • Regulation of experimental allergic encephalomyelitis. Part 4. Further characterization of postrecovery suppressor cells
    • Killen, J. A., Swanborg, R. H. (1982) Regulation of experimental allergic encephalomyelitis. Part 4. Further characterization of postrecovery suppressor cells. J. Neuroimmunol. 3, 159-166.
    • (1982) J. Neuroimmunol. , vol.3 , pp. 159-166
    • Killen, J.A.1    Swanborg, R.H.2
  • 51
    • 0034658388 scopus 로고    scopus 로고
    • Systemic immune deviation in the brain that does not depend on the integrity of the blood-brain barrier
    • Wenkel, H., Streilein, J. W., Young, M. J. (2000) Systemic immune deviation in the brain that does not depend on the integrity of the blood-brain barrier. J. Immunol. 164, 5125-5131.
    • (2000) J. Immunol. , vol.164 , pp. 5125-5131
    • Wenkel, H.1    Streilein, J.W.2    Young, M.J.3
  • 52
    • 0026571065 scopus 로고
    • Studies on the induction of anterior chamber-associated immune deviation (ACAID). III. Induction of ACAID depends upon intraocular transforming growth factor-β
    • Wilbanks, G. A., Mammolenti, M., Streilein, J. W. (1992) Studies on the induction of anterior chamber-associated immune deviation (ACAID). III. Induction of ACAID depends upon intraocular transforming growth factor-β. Eur. J. Immunol. 22, 165-173.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 165-173
    • Wilbanks, G.A.1    Mammolenti, M.2    Streilein, J.W.3


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