Targeting the chemokine network in renal inflammation

Archivum Immunologiae et Therapiae Experimentalis

Volumn 52, Issue 3, 2004, Pages 164-172

  Eis, Vaclav ^a,b   Vielhauer, Volker ^a   Anders, Hans Joachim ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Chemokines; Fibrosis; Inflammation; Kidney disease

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR5; CC CHEMOKINE RECEPTOR 1; CHEMOKINE RECEPTOR; MONOCYTE CHEMOATTRACTANT PROTEIN 1 RECEPTOR;

CELL INFILTRATION; HUMAN; KIDNEY DISEASE; NEPHRITIS; NONHUMAN; PATHOGENESIS; PHENOTYPE; REVIEW; T LYMPHOCYTE; ANIMAL; IMMUNOLOGY; INFLAMMATION; LEUKOCYTE; METABOLISM;

ANIMALS; CHEMOKINES; HUMANS; INFLAMMATION; KIDNEY DISEASES; LEUKOCYTES; RECEPTORS, CHEMOKINE;

EID: 16644396815     PISSN: 0004069X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (70)

1. Akira S. and Hemmi H. (2003): Recognition of pathogen-associated molecular patterns by TLR family. Immunol. Lett., 85, 85-95.
2. Anders H. J., Banas B., Linde Y., Weller L., Cohen C. D., Kretzler M., Martin S., Vielhauer V., Schlöndorff D. and Gröne H. J. (2003): Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors. J. Am. Soc. Nephrol., 14, 317-326.
3. Anders H. J., Frink M., Linde Y., Banas B., Wornle M., Cohen C. D., Vielhauer V., Nelson P. J., Gröne H. J. and Schlöndorff D. (2003): CC chemokine ligand 5/RANTES chemokine antagonists aggravate glomerulonephritis despite reduction of glomerular leukocyte infiltration. J. Immunol., 170, 5658-5666.
4. Anders H. J., Vielhauer V., Frink M., Linde Y., Cohen C. D., Blattner S. M., Kretzler M., Strutz F., Mack M., Grone H. J., Onuffer J., Horuk R., Nelson P. J. and Schlondorff D. (2002): A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J. Clin. Invest., 109, 251-259.
5. Anders H. J., Vielhauer V., Kretzler M., Cohen C.D., Segerer S., Luckow B., Weller L., Grone H. J. and Schlondorff D. (2001): Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritis. J. Am. Soc. Nephrol., 12, 919-931.
6. Anders H. J., Vielhauer V. and Schlöndorff D. (2003): Chemokines and chemokine receptors are involved in the resolution or progression of renal disease. Kidney Int., 63, 401-415.
7. Baggiolini M. (1998): Chemokines and leukocyte traffic. Nature, 392, 565-568.
8. Banas B., Luckow B., Moller M., Klier C., Nelson P.J., Schadde E., Brigl M., Halevy D., Holthofer H., Reinhart B. and Schlondorff D. (1999): Chemokine and chemokine receptor expression in a novel human mesangial cell line. J. Am. Soc. Nephrol., 10, 2314-2322.
9. Banas B., Wornle M., Berger T., Nelson P. J., Cohen C. D., Kretzler M., Pfirstinger J., Mack M., Lipp M., Grone H.J. and Schlondorff D. (2002): Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis. J. Immunol., 168, 4301-4307.
10. Banba N., Nakamura T., Matsumura M., Kuroda H., Hattori Y. and Kasai K. (2000): Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy. Kidney Int., 58, 684-690.
11. Bird J. E., Giancarli M. R., Kurihara T., Kowala M. C., Valentine M. T., Gitlitz P. H., Pandya D. G., French M. H. and Durham S. K. (2000): Increased severity of glomerulonephritis in C-C chemokine receptor 2 knockout mice. Kidney Int., 57, 129-136.
12. Blanpain C., Migeotte I., Lee B., Vakili J., Doranz B. J., Govaerts C., Vassart G., Doms R. W. and Parmentier M. (1999): CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood, 94, 1899-1905.
13. Bruhl H., Cihak J., Stangassinger M., Schlondorff D. and Mack M. (2001): Depletion of CCR5-expressing cells with bispecific antibodies and chemokine toxins: A new strategy in the treatment of chronic inflammatory diseases and HIV. J. Immunol., 166, 2420-2426.
14. Cockwell P., Chakravorty S. J., Girdlestone J. and Savage C. O. (2002): Fractalkine expression in human renal inflammation. J. Pathol., 196, 85-90.
15. Eddy A. A. (2000): Molecular basis of renal fibrosis. Pediatr. Nephrol., 15, 290-301.
16. Fujinaka H., Yamamoto T., Takeya M., Feng L., Kawasaki K., Yaoita E., Kondo D., Wilson C. B., Uchiyama M. and Kihara I. (1997): Suppression of anti-glomerular basement membrane nephritis by administration of anti-monocyte chemoattractant protein-1 antibody in WKY rats. J. Am. Soc. Nephrol., 8, 1174-1178.
17. Furuichi K., Wada T., Iwata Y., Kitagawa K., Kobayashi K., Hashimoto H., Ishiwata Y., Asano M., Wang H., Matsushima K., Takeya M., Kuziel W. A., Mukaida N. and Yokoyama H. (2003): CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J. Am. Soc. Nephrol., 14, 2503-2515.
18. Furuichi K., Wada T., Iwata Y., Kitagawa K., Kobayashi K., Hashimoto H., Ishiwata Y., Tomosugi N., Mukaida N., Matsushima K., Egashira K. and Yokoyama H. (2003): Gene therapy expressing amino-terminal truncated monocyte chemoattractant protein-1 prevents renal ischemia-reperfusion injury. J. Am. Soc. Nephrol., 14, 1066-1071.
19. Furuichi K., Wada T., Sakai N., Iwata Y., Yoshimoto K., Shimizu M., Kobayashi K., Takasawa K., Kida H., Takeda S. I., Mukaida N., Matsushima K. and Yokoyama H. (2000): Distinct expression of CCR1 and CCR5 in glomerular and interstitial lesions of human glomerular diseases. Am. J. Nephrol., 20, 291-299.
20. Grandaliano G., Gesualdo L., Ranieri E., Monno R., Montinaro V., Marra F. and Schena F. P. (1996): Monocyte chemotactic peptide-1 expression in acute and chronic human nephritides: a pathogenelic role in interstitial monocytes recruitment. J. Am. Soc. Nephrol., 7, 906-913.
21. Grandaliano G., Gesualdo L., Ranieri E., Monno R., Stallone G. and Schena F. P. (1997): Monocyte chemotactic peptide-1 expression and monocyte infiltration in acute renal transplant rejection. Transplantation., 63, 414-420.
22. Hasegawa H., Kohno M., Sasaki M., Inoue A., Ito M. R., Terada M., Hieshima K., Maruyama H., Miyazaki J., Yoshie O., Nose M. and Fujita S. (2003): Antagonist of monocyte chemoattractant protein 1 ameliorates the initiation and progression of lupus nephritis and renal vasculitis in MRL/lpr mice. Arthritis Rheum., 48, 2555-2566.
23. Hilgers K. F., Hartner A., Porst M., Mai M., Wittmann M., Hugo C., Ganten D., Geiger H., Veelken R. and Mann J. F. (2000): Monocyte chemoattractant protein-1 and macrophage infiltration in hypertensive kidney injury. Kidney Int., 58, 2408-2419.
24. Horuk R., Shurey S., Ng H. P., May K., Bauman J. G., Islam I., Ghannam A., Buckman B., Wei G. P., Xu W., Liang M., Rosser M., Dunning L., Hesselgesser J., Snider R. M., Morrissey M. M., Perez H. D. and Green C. (2001): CCR1-specific non-peptide antagonist: efficacy in a rabbit allograft rejection model. Immunol. Lett., 76, 193-201.
25. Kaufmann A., Salentin R., Gemsa D. and Sprenger H. (2001): Increase of CCR1 and CCR5 expression and enhanced functional response to MIP-1α during differentiation of human monocytes to macrophages. J. Leukoc. Biol., 69, 248-252.
26. Klier C. M., Nelson E. L., Cohen C. D., Horuk R., Schlondorff D. and Nelson P. J. (2001): Chemokine-induced secretion of gelatinase B in primary human monocytes. Biol. Chem., 382, 1405-1410.
27. Leppert D., Waubant E., Galardy R., Bunnett N. W. and Hauser S. L. (1995): T cell gelatinases mediate basement membrane transmigration m vitro. J. Immunol., 154, 4379-4389.
28. Liu Z. H, Chen S. F., Zhou H., Chen H. P. and Li L. S. (2003): Glomerular expression of C-C chemokines in different types of human crescentic glomerulonephritis. Nephrol. Dial. Transplant., 18, 1526-1534.
29. Lloyd C. M., Minto A. W., Dorf M. E., Proudfoot A., Wells T. N., Salant D. J. and Gutierrez-Ramos J. C. (1997): RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis. J. Exp. Med., 185, 1371-1380.
30. Luster A. D. (1998): Chemokines - chemotactic cytokines that mediate inflammation. N. Engl. J. Med., 338, 436-445.
31. Luther S. A. and Cyster J. G. (2001): Chemokines as regulators of T cell differentiation. Nat. Immunol., 2, 102-107.
32. Moser B. and Loetscher P. (2001): Lymphocyte traffic control by chemokines. Nat. Immunol., 2, 123-128.
33. Murphy P. M., Baggiolini M., Charo I. F., Hebert C. A., Horuk R., Matsushima K., Miller L. H., Oppenheim J. J. and Power C. A. (2000): International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol. Rev., 52, 145-176.
34. Naya A., Ishikawa M., Matsuda K., Ohwaki K., Saeki T., Noguchi K. and Ohtake N. (2003): Structure-activity relationships of xanthene carboxamides, novel CCR1 receptor antagonists. Bioorg. Med. Chem., 11, 875-884.
35. Nelson P. J. and Krensky A. M. (2001): Chemokines, chemokine receptors, and allograft rejection. Immunity, 14, 377-386.
36. Noris M., Bernasconi S., Casiraghi F., Sozzani S., Gotti E., Remuzzi G. and Mantovani A. (1995): Monocyte chemoattractant protein-1 is excreted in excessive amounts in the urine of patients with lupus nephritis. Lab. Invest., 73, 804-809.
37. Ogilvie P., Paoletti S., Clark-Lewis I. and Uguccioni M. (2003): Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytes. Blood, 102, 789-794.
38. Okada IL, Moriwaki K., Kalluri R., Imai H., Ban S., Takahama M. and Suzuki H. (2000): Inhibition of monocyte chemoattractant protein-1 expression in tubular epithelium attenuates tubulointerstitial alteration in rat Goodpasture syndrome. Kidney Int., 57, 927-936.
39. Onuffer J. J. and Horuk R. (2002): Chemokines, chemokine receptors and small-molecule antagonists: recent developments. Trends Pharmacol. Sci., 23, 459-467.
40. Ostermann G., Weber K. S., Zernecke A., Schroder A. and Weber C. (2002): JAM-1 is a ligand of the β(2) integrin LFA-1 involved in transendothelial migration of leukocytes. Nat. Immunol., 3, 151-158.
41. Perez de Lema G., Maier H., Nieto E., Vielhauer V., Luckow B., Mampaso F. and Schlondorff D. (2001): Chemokine expression precedes inflammatory cell infiltration and chemokine receptor and cytokine expression during the initiation of murine lupus nephritis. J. Am. Soc. Nephrol., 12, 1369-1382.
42. Romagnani P., Beltrame C., Annunziato F., Lasagni L., Luconi M., Galli G., Cosmi L., Maggi E., Salvadori M., Pupilli C. and Serio M. (1999): Role for interactions between IP-10/Mig and CXCR3 in proliferative glomerulonephritis. J. Am. Soc.Nephrol., 10, 2518-2526.
43. Rossi D. and Zlotnik A. (2000): The biology of chemokines and their receptors. Annu. Rev. Immunol., 18, 217-242.
44. Saitoh A., Sekizuka K., Hayashi T., Kaneko S., Suzuki Y. and Tomino Y. (1998): Detection of urinary MCP-1 in patients with diabetic nephropathy (letter). Nephron, 80, 99.
45. Sallusto F., MacKay C. R. and Lanzavecchia A. (2000): The role of chemokine receptors in primary, effector, and memory immune responses. Annu. Rev. Immunol., 18, 593-620.
46. Segerer S., Cui Y., Hudkins K.L., Goodpaster T., Eitner F., Mack M., Schlondorff D. and Alpers C. E. (2000): Expression of the chemokine monocyte chemoattractant protein-1 and its receptor chemokine receptor 2 in human crescentic glomerulonephritis. J. Am. Soc. Nephrol., 11, 2231-2242.
47. Segerer S., Nelson P. J. and Schlöndorff D. (2000): Chemokines, chemokine receptors, and renal disease: From basic science to pathophysiologic and therapeutic studies. J. Am. Soc. Nephrol., 11, 152-176.
48. Segerer S., Regele H., Mack M., Kain R., Cartron J.P., Colin Y., Kerjaschki D. and Schlondorff D. (2000): The Duffy antigen receptor for chemokines is up-regulated during acute renal transplant rejection and crescentic glomerulonephritis. Kidney Int., 58, 1546-1556.
49. Shimizu U., Maruyama S., Yuzawa Y., Kato T., Miki Y., Suzuki S., Sato W., Morita Y., Maruyama H., Egashira K. and Matsuo S. (2003): Anti-monocyte chemoattractant protein-1 gene therapy attenuates renal injury induced by protein-overload proteinuria. J. Am. Soc. Nephrol., 14, 1496-1505.
50. Takaya K., Koya D., Isono M., Sugimoto T., Sugaya T., Kashiwagi A. and Haneda M. (2003): Involvement of ERK pathway in albumin-induced MCP-1 expression in mouse proximal tubular cells. Am. J. Physiol. Renal. Physiol., 284, F1037-1045.
51. Tanaka Y., Adams D. H., Hubscher S., Hirano H., Siebenlist U. and Shaw S. (1993): T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1β. Nature, 361, 79-82.
52. Tang W. W., Qi M. and Warren J. S. (1996): Monocyte chemoattractant protein 1 mediates glomerular macrophage infiltration in anti-GBM Ab GN. Kidney Int., 50, 665-671.
53. Tesch G. H., Schwarting A., Kinoshita K., Lan H. Y., Rollins B. J. and Kelley V. R. (1999): Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis. J. Clin. Invest., 103, 73-80.
54. Tesch G. H., Maifert S., Schwarting A., Rollins B. J. and Kelley V. R. (1999): Monocyte chemoattractant protein 1-dependent leukocytic infiltrates are responsible for autoimmune disease in MRL-Fas(lpr) mice. J. Exp. Med., 190, 1813-1824.
55. Tokuda A., Itakura M., Onai N., Kimura H., Kuriyama T. and Matsushima K. (2000): Pivotal role of CCR1-positive leukocytes in bleomycin-induced lung fibrosis in mice. J. Immunol., 164, 2745-2751.
56. Topham P. S., Csizmadia V., Soler D., Hines D., Gerard C. J., Salant D. J. and Hancock W. W. (1999): Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis. J. Clin. Invest., 104, 1549-1557.
57. Tsuboi N., Yoshikai Y., Matsuo S., Kikuchi T., Iwami K., Nagai Y., Takeuchi O., Akira S. and Matsuguchi T. (2002): Roles of Toll-like receptors in C-C chemokine production by renal tubular epithelial cells. J. Immunol., 169, 2026-2033.
58. Umekawa T., Chegini N. and Khan S. R. (2003): Increased expression of monocyte chemoattractant protein-1 (MCP-1) by renal epithelial cells in culture on exposure to calcium oxalate, phosphate and uric acid crystals. Nephrol. Dial. Transplant., 18, 664-669.
59. Vielhauer V., Anders H. J., Mack M., Cihak J., Strutz F., Stangassinger M., Luckow B., Grone H. J. and Schlondorff D. (2001): Obstructive nephropathy in the mouse: Progressive fibrosis correlates with tubulointerstitial chemokine expression and accumulation of CC chemokine receptor 2 and 5 positive leukocytes. J. Am. Soc. Nephrol., 12, 1173-1187.
60. Vielhauer V., Berning E., Linde Y., Kretzler M., Strutz F., Horuk R., Grone H. J., Schlondorff D. and Anders H. J. (2003): A CCR1 antagonist reduces interstitial nephritis and fibrosis, but not proteinuria and glomerular pathology in murine adriamycin nephropathy. J. Am. Soc. Nephrol., 14, F-PO482.
61. Wada T., Furuichi K., Sakai N., Iwata Y., Yoshimoto K., Shimizu M., Takeda S. I., Takasawa K., Yoshimura M., Kida H., Kobayashi K.I., Mukaida N., Naito T., Matsushima K. and Yokoyama H. (2000): Up-regulation of monocyte chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy. Kidney Int., 58, 1492-1499.
62. Wada T., Yokoyama U., Su S. B., Mukaida N., Iwano M., Dohi K., Takahashi Y., Sasaki T., Furuichi K., Segawa C., Hisada Y., Ohta S., Takasawa K., Kobayashi K. and Matsushima K. (1996): Monitoring urinary levels of monocyte chemotactic and activating factor reflects disease activity of lupus nephritis. Kidney. Int., 49, 761-767.
63. Wang Y., Rangan G. K., Tay Y. C., Wang Y. and Harris D. C. (1999): Induction of monocyte chemoattractant protein-1 by albumin is mediated by nuclear factor κB in proximal tubule cells. J. Am. Soc. Nephrol., 10, 1204-1213.
64. Weber C., Weber K. S., Klier C., Gu S., Wank R., Horuk R. and Nelson P. J. (2001): Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and Th1-like/CD45RO(+) T cells. Blood, 97, 1144-1146.
65. Weber K. S., von Hundelshausen P., Clark-Lewis I., Weber P. C. and Weber C. (1999): Differential immobilization and hierarchical involvement of chemokines in monocyte arrest and transmigration on inflamed endothelium in shear flow. Eur. J. Immunol., 29, 700-712.
66. Wenzel U., Schneider A., Valente A. J., Abboud H. E., Thaiss F., Helmchen U. M. and Stahl R. A. (1997): Monocyte chemoattractant protein-1 mediates monocyte/macrophage influx in anti-thymocyte antibody-induced glomerulonephritis. Kidney Int., 51, 770-776.
67. Zlotnik A. and Yoshie O. (2000): Chemokines: A new classification system and their role in immunity. Immunity, 12, 121-127.
68. Zoja C., Donadelli R., Colleoni S., Figliuzzi M., Bonazzola S., Morigi M. and Remuzzi G. (1998): Protein overload stimulates RANTES production by proximal tubular cells depending on NF-κB activation. Kidney Int., 53, 1608-1615.
69. Zoja C., Liu X. H., Donadelli R., Abbate M., Testa D., Corna D., Taraboletti G., Vecchi A., Dong Q. G., Rollins B. J., Bertani T. and Remuzzi G. (1997): Renal expression of monocyte chemoattractant protein-1 in lupus autoimmune mice. J. Am. Soc. Nephrol., 8, 720-729.
70. Eis V., Luckow B., Vielhauer V., Siveke J. T., Linde Y., Segerer S., De Lema G. P., Cohen C. D., Kretzler M., Mack M., Horuk R., Murphy P. M., Gao J. L., Hudkins K. L., Alpers C. E., Grone H. J., Schlondorff D. and Anders H. J. (2004): Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction. J. Am. Soc. Nephrol., 15, 337-347.