A benzoic acid inhibitor induces a novel conformational change in the active site of Influenza B virus neuraminidase

Acta Crystallographica Section D: Biological Crystallography

Volumn 60, Issue 6, 2004, Pages 1017-1023

  Lommer, Barbara S ^a,d   Ali, Shoukath M ^b   Bajpai, Saroj N ^b   Brouillette, Wayne J ^b   Air, Gillian M ^c   Luo, Ming ^a,b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^d MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA B VIRUS; INFLUENZAVIRUS B;

2 PYRROLIDONE DERIVATIVE; AMINOBENZOIC ACID DERIVATIVE; BANA 207; BENZOIC ACID; CARBOHYDRATE; ENZYME INHIBITOR; GLUTAMIC ACID; GLYCEROL; N ACETYLNEURAMINIC ACID; SIALIDASE;

ARTICLE; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ELECTRON; ENZYMOLOGY; HYDROGEN BOND; IC 50; INFLUENZA VIRUS B; METABOLISM; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; VIRION; X RAY CRYSTALLOGRAPHY;

AMINOBENZOIC ACIDS; BENZOIC ACID; BINDING SITES; CARBOHYDRATES; CRYSTALLOGRAPHY, X-RAY; ELECTRONS; ENZYME INHIBITORS; GLUTAMIC ACID; GLYCEROL; HYDROGEN BONDING; INFLUENZA B VIRUS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MODELS, MOLECULAR; N-ACETYLNEURAMINIC ACID; NEURAMINIDASE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PYRROLIDINONES; VIRION;

EID: 16644374078     PISSN: 09074449     EISSN: None     Source Type: Journal    
DOI: 10.1107/S0907444904006225     Document Type: Article

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