Novel aromatic inhibitors of influenza virus neuraminidase make selective interactions with conserved residues and water molecules in the active site

Journal of Molecular Biology

Volumn 293, Issue 5, 1999, Pages 1107-1119

  Finley, James B ^c   Atigadda, Venkatram R ^a   Duarte, Franco ^a   Zhao, James J ^c   Brouillette, Wayne J ^a   Air, Gillian M ^b   Luo, Ming ^c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c NONE

Author keywords

Hydrophobic pocket; Influenza virus; Neuraminidase; Structure based drug design

Indexed keywords

BENZENE; BENZOIC ACID; GLUTAMIC ACID; SIALIC ACID; SIALIDASE INHIBITOR; VIRUS SIALIDASE;

ARTICLE; ENZYME ACTIVE SITE; GENETIC CONSERVATION; HYDROPHOBICITY; INFLUENZA VIRUS; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

INFLUENZA VIRUS; RNA VIRUSES;

EID: 0033550314     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3180     Document Type: Article

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