Preparation of protected peptidyl thioester intermediates for native chemical ligation by Nα-9-fluorenylmethoxycarbonyl (Fmoc) chemistry: Considerations of side-chain and backbone anchoring strategies, and compatible protection for N-terminal cysteine

Journal of Peptide Research

Volumn 65, Issue 3, 2005, Pages 395-410

  Gross, C M ^a,b,c   Lelievre D ^a,d   Woodward, C K ^b   Barany, G ^a  

^a University of Minnesota   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CENTRE DE BIOPHYSIQUE MOLÉCULAIRE   (France)

Author keywords

9 fluorenylmethoxycarbonyl (Fmoc) strategy; Backbone amide linker (BAL); Bovine pancreatic trypsin inhibitor (BPTI); C terminal thioester intermediates; Carbamoyl disulfide (Snm) protection for cysteine; Native chemical ligation

Indexed keywords

CARBONYL DERIVATIVE; CYSTEINE; NALPHA 9 FLUORENYLMETHOXYCARBONYL DERIVATIVE; NALPHA 9 FLUORENYLMETHOXYCARBONYL S (N METHYL N PHENYLCARBAMOYL)SULFENYLCYSTEINE; NALPHA 9 FLUORENYLMETHOXYCARBONYL S TRIPHENYLMETHYLCYSTEINE; NALPHA TERT BUTYLOXYCARBONYL DERIVATIVE; NALPHA TERT BUTYLOXYCARBONYL S FLUORENYLMETHYLCYSTEINE; TERT BUTYL ALCOHOL; THIOESTER; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; COMBINATORIAL CHEMISTRY; DEPROTECTION REACTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PURIFICATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; AMINO ACIDS; APROTININ; CYSTEINE; FLUORENES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; SULFUR COMPOUNDS;

EID: 16444367587     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3011.2005.00241.x     Document Type: Article

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