Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 3, 2004, Pages 639-643

  Dinsmore, Christopher J ^a   Zartman, C Blair ^a   Bergman, Jeffrey M ^a   Abrams, Marc T ^a   Buser, Carolyn A ^a   Culberson, J Christopher ^a   Davide, Joseph P ^a   Ellis Hutchings, Michelle ^a   Fernandes, Christine ^a   Graham, Samuel L ^a   Hartman, George D ^a   Huber, Hans E ^a   Lobell, Robert B ^a   Mosser, Scott D ^a   Robinson, Ronald G ^a   Williams, Theresa M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Farnesyltransferase; Geranylgernyltransferase; Inhibitor

Indexed keywords

GERANYLGERANYLTRANSFERASE I; ISOENZYME; KETONE DERIVATIVE; L 778123; MACROCYCLIC COMPOUND; PIPERAZINE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL CULTURE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PRENYLATION;

EID: 1642575098     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.11.051     Document Type: Article

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