Transforming growth factor beta 1 is significantly elevated in plasma of patients suffering from renal cell carcinoma

Cytokine

Volumn 8, Issue 10, 1996, Pages 794-798

  Junker, U ^a   Knoefel, B ^a   Nuske, K ^a   Rebstock, K ^b   Steiner, T ^a   Wunderlich, H ^a   Junker, K ^a   Reinhold, D ^c  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b Thueringen Krankhs Saalfeld A   (Germany)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Immunomodulation; Plasma level; Renal cell carcinoma; TGF 1

Indexed keywords

MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; PRIORITY JOURNAL;

EID: 0030268104     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1996.0105     Document Type: Article

References (18)

1. 1. Hayakawa M, Hatano T, Ogawa Y, Gakiya M, Ogura H, Osawa A (1994) Treatment of advanced renal cell carcinoma using regional arterial administration of lymphokine-activated killer cells in combination with low doses of rIL-2. Urol Int 53:117-124.
2. 2. Larsson P (1994) Cell proliferation in renal cell carcinoma. Scan J Urology Nephrol (Suppl.) 165:1-48.
3. 3. Miki S, Iwano M, Miki Y, Yamamoto M, Tang B, Yokokawa K, Sonoda T, Hirano T, Kishimoto T (1989) IL-6 functions as an autocrine growth factor in renal carcinomas. FEBS Lett 250:607-610.
4. 4. Takenawa J, Kanako Y, Fukyomoto M, Fukatsu A, Hirano T, Fukuyama H, Nakayama F, Fujita J, Yoshida O (1991) Enhanced expression of IL-6 in primary human renal cell carcinoma. J Natl Cancer Inst 3:1668-1672.
5. 5. Knoefel B, Junker U, Nuske K, El-Seweifi A, Junker K, Kosmehl H, Jäger L (1995) Untersuchungen von Primärkulturen verschiedener Nierenzellkarzinome in Hinblick auf immunmodulatorische Effekte. Immun Infekt 23:72-73.
6. 6. Phillips AO, Steadman R, Topley N, Williams JD (1995) Elevated D-glucose concentrations modulate TGF-beta 1 synthesis by human cultured renal proximal tubular cells: The permissive role of platelet-derived growth factor. Am J Pathol 147:362-374.
7. 7. Taga K, Mostowski H, Tosato G (1993) Human interleukin-10 can directly inhibit T-cell growth. Blood 81: 2964-2971.
8. 8. Barnard JA, Lyons RM, Moses HM (1990) The cell biology of transforming growth factor beta. Biochem Biophys Acta 1032:79-87.
9. 9. Reinhold D, Bank U, Bühling F, Lendeckel U, Ulmer AJ, Flad HD, Ansorge S (1994) Transforming growth factor-β1 (TGF-β1) inhibits DNA synthesis of PWM-stimulated PBMC via suppression of IL-2 and IL-6 production. Cytokine 6:382-388.
10. 10. Reinhold D, Bank U, Bühling F, Lendeckel U, Ansorge S (1995) Transforming growth factor β1 inhibits Interleukin-10 mRNA expression and production in pokeweed mitogen-stimulated peripheral blood mononuclear cells and T cells. J Interferon Res 15:685-690.
11. 11. Cerwenka A, Bevec D, Majdic O, Knapp W, Holter W (1994) TGF-β1 is a potent inducer of human effector T cells. J Immunol 153:4367-4377.
12. 12. Varricchio F, Obiri NI, Haas GP, Puri RK (1993) Immunostaining of interleukin-4 receptor on human renal cell carcinoma. Lymphokine Res 12:465-469.
13. 13. Obiri NI, Hillman GG, Haas GP, Sud S, Puri RK (1993) Expression of high affinity interleukin-4 receptors on human renal cell carcinoma cells and inhibition of tumour cell growth in vitro by interleukin-4. J Clin Invest 91:88-93.
14. 14. Hillman GG, Puri RK, Kukuruga MA, Pontes JE, Haas GP (1994) Growth and major histocompatibility antigen expression regulation by IL-4, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) on human renal cell carcinoma. Clin Exp Immunol 6:476-483.
15. 15. Obiri NI, Tandon N, Puri RK (1995) Up-regulation of intercellular adhesion molecule 1 (ICAM-1) on human renal cell carcinoma cells by interleukin-4. Int J Cancer 61:635-642.
16. 16. Grainger DJ, Mosedale DE, Metcalfe JC, Weissberg PL, Kemp PR (1995) Active and acid-activatable TGF-beta in human sera, platelets and plasma. Clin Chim Acta. 235:11-31.
17. 17. Stonans I, Stonane E, Vogelsang H, Junker U, Jäger L (1996) Differential expression of cytokine genes in CD27 positive and negative CD4 lymphocyte subsets from healthy human and rheumatoid arthritis patients. Rheum Int, in press.
18. 18. Danielpour D (1993) Improved sandwich enzyme-linked immunosorbent assays for transforming growth factor beta-1. J Immunol Methods 158:17-25.