Cyclopentenone prostaglandins induce endothelial cell apoptosis independent of the peroxisome proliferator-activated receptor-γ

European Journal of Immunology

Volumn 34, Issue 1, 2004, Pages 241-250

  Erl, Wolfgang ^a   Weber, Christian ^b   Zernecke, Alma ^a   Neuzil, Jiri ^c   Vosseler, Claudia A ^a   Kim, Hyo Jung ^a   Weber, Peter C ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^c GRIFFITH UNIVERSITY   (Australia)

Author keywords

Apoptosis; Endothelial cell; Inflammation; Lipid mediator; Transcription factor

Indexed keywords

CASPASE; CASPASE 3; CASPASE INHIBITOR; CELL RECEPTOR; CYCLOPENTENONE; DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PHOSPHATIDYLSERINE; PIRINIXIC ACID; PROSTAGLANDIN; PROSTAGLANDIN A; PROSTAGLANDIN A1; PROSTAGLANDIN J2; ROSIGLITAZONE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL COUNT; CELL CYCLE; CELL DEATH; CELL DIFFERENTIATION; CELL NUCLEUS; CELL TYPE; CELL VIABILITY; CONTROLLED STUDY; DNA CONTENT; DRUG EFFECT; ENDOTHELIUM; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; ENZYME ACTIVATION; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; INHIBITION KINETICS; METABOLISM; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; STEM CELL; TIME; UMBILICAL VEIN;

EID: 1642554781     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324053     Document Type: Article

References (39)

1. Palmer, C. N., Hsu, M. H., Griffin, K. J. and Johnson, E. F., Novel sequence determinants in peroxisome proliferator signaling. J. Biol. Chem. 1995. 270: 16114-16121.
2. Spiegelman, B. M., PPAR-γ: adipogenic regulator and thiazolidinedione receptor. Diabetes 1998. 47: 507-514.
3. Chinetti, G., Griglio, S., Antonucci, M., Torra, I. P., Delerive, P., Majd, Z., Fruchart, J., Chapman, J., Najib, J. and Staels, B., Activation of proliferator-activated receptors α and γ induces apoptosis of human monocyte-derived macrophages. J. Biol. Chem. 1998. 273: 25573-25580.
4. Law, R. E., Goetze, S., Xi, X. P., Jackson, S., Kawano, Y., Demer, L., Fishbein, M. C., Meehan, W. P. and Hsueh, W. A., Expression and function of PPARγ in rat and human vascular smooth muscle cells. Circulation 2000. 101: 1311-1318.
5. Marx, N., Bourcier, T., Sukhova, G. K., Libby, P. and Plutzky, J., PPARγ activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARγ as a potential mediator in vascular disease. Arterioscler. Thromb. Vasc. Biol. 1999. 19: 546-551.
6. Jiang, C., Ting, A. T. and Seed, B., PPARγ agonists inhibit production of monocyte inflammatory cytokines. Nature 1998. 39: 82-86.
7. 2 inhibits multiple steps in the NF-κB signaling pathway. Proc. Natl. Acad. Sci. USA 2000. 97: 4844-4849.
8. 1 on glutathione metabolism in human cancer cells in culture. Biochem. Mol. Biol. Int. 1998. 45: 1255-1264.
9. Tsubouchi, Y., Sano, H., Kawahito, Y., Mukai, S., Yamada, R., Kohno, M., Inoue, K., Hia, T. and Kondo, M., Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-γ agonists through induction of apoptosis. Biochem. Biophys. Res. Commun. 2000. 270: 400-405.
10. 2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. J. Clin. Invest. 2000. 106: 189-197.
11. 2 is a ligand for the adipocyte determination factor PPARγ. Cell 1995. 83: 803-812.
12. Hortelano, S., Castrillo, A., Alvarez, A. M. and Bosca, L., Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages. J. Immunol. 2000. 165: 6525-6531.
13. Staels, B., Koenig, W., Habib, A., Merval, R., Lebret, M., Torra, I. P., Delerive, P., Fadel, A., Chinetti, G., Fruchart, J.-C., Najib, J., Maclouff, J. and Tedgui, A., Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature 1998. 393: 790-793.
14. Marx, N., Schonbeck, U., Lazar, M. A., Libby, P. and Plutzky, J., Peroxisome proliferator-activated receptor γ activators inhibit gene expression and migration in human vascular smooth muscle cells. Circ. Res. 1998. 83: 1097-1103.
15. Marx, N., Sukhova, G. K., Collins, T., Libby, P. and Plutzky, J., PPARα activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 1999. 99: 3125-3131.
16. 2. J. Biol. Chem. 1999. 274: 17042-17048.
17. Haunstetter, A. and Izumo, S., Apoptosis. Basic mechanisms and implications for cardiovascular disease. Circ. Res. 1998. 82: 1111-1129.
18. Kato, K., Satoh, H., Endo, Y., Yamada, D., Midorikawa, S., Sato, W., Mizuno, K., Fujita, T., Tsukamoto, K. and Watanabe, T., Thiazolidinediones down-regulate plasminogen activator inhibitor type 1 expression in human vascular endothelial cells: A possible role for PPARγ in endothelial function. Biochem. Biophys. Res. Commun. 1999. 258: 431-435.
19. Xin, X., Yang, S., Kowalski, J. and Gerritsen, M. E., Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo. J. Biol. Chem. 1999. 74: 9116-9121.
20. Tontonoz, P., Hu, E. and Spiegelman, B. M., Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 1994. 79: 1147-1156.
21. Jostarndt, K., Rubic, T., Kuhn, H., Anthosen, M. W., Andera, L., Gellert, N., Trottman, M., Weber, C., Johansen, B., Hrboticky, N. and Neuzil, J., Enzymatically modified low-density lipoprotein upregulates CD36 in low-differentiated monocytic cells in a peroxisome proliferator-activated receptor-γ-dependent way. Biochem. Pharmacol. 2003, in press.
22. Brown, J., Reading, S. J., Jones, S., Fitchett, C. J., Howl, J., Martin, A., Longland, C. L., Michelangeli, F., Dubrova, Y. E. and Brown, C. A., Critical evaluation of ECV304 as a human endothelial cell model defined by genetic analysis and functional responses: a comparison with the human bladder cancer-derived epithelial cell line T24/83. Lab. Invest. 2000. 80: 37-45.
23. Levkau, B., Scatena, M., Giachelli, C. M., Ross, R. and Raines, E. W., Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-κB loop. Nat. Cell. Biol. 1999. 1: 227-233.
24. 2 inhibits the β2 integrin-dependent oxidative burst: involvement of a mechanism distinct from peroxisome proliferator-activated receptor γ ligation. J. Immunol. 1999. 163: 6187-6192.
25. Thieringer, R., Fenyk-Melody, J. E., Le Grand, C. B., Shelton, B. A., Detmers, P. A., Somers, E. P., Carbin, L., Moller, D. E., Wright, S. D. and Berger, J., Activation of peroxisome proliferator-activated receptor γ does not inhibit IL-6 or TNF-α responses of macrophages to lipopolysaccharide in vitro or in vivo. J. Immunol. 2000. 164: 1046-1054.
26. Wang, M., Wise, S. C., Leff, T. and Su, T. Z., Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-γ. Diabetes 1999. 48: 254-260.
27. Neuzil, J., Schröder, A., von Hundelshausen, P., Zernecke, A., Gellert, N. and Weber, C., Inhibition of inflammatory endothelial responses by a pathway involving caspase activation and p65 cleavage. Biochemistry 2001. 40: 4686-4692.
28. Zernecke, A., Erl, W., Fraemohs, L., Lietz, M. and Weber, C., Suppression of endothelial adhesion molecule upregulation with cyclopentenone prostaglandins is dissociated from IkB kinase inhibition and cell death induction. FASEB J. 2003. 17: 1099-1110.
29. 2 on glutathione induction and apoptosis in human endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2001. 21: 1846-1851.
30. Hauser, S., Adelmant, G., Sarraf, P., Wright, H. M., Mueller, E. and Spiegelman, B. M., Degradation of the peroxisome proliferator-activated receptor γ is linked to ligand-dependent activation. J. Biol. Chem. 2000. 275: 18527-18533.
31. Erl, W., Weber, C., Wardemann, C. and Weber, P. C., α-Tocopheryl succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-κB mobilization. Am. J. Physiol. 1997. 273: 634-640.
32. Chawla, A., Barak, Y., Nagy, L., Liao, D., Tontonoz, P. and Evans, R. M., PPARγ-dependent and independent effects on macrophage gene expression in lipid metabolism and inflammation. Nat. Med. 2001. 7: 48-52.
33. Kennedy, V., Firpo, M., Choi, K., Wall, C., Robertson, S., Kabrun, N. and Keller, G., A common precursor for primitive and definitive haematopoesis. Nature 1997. 386: 488-493.
34. Gurnell, M., Wentworth, J. M., Agostini, M., Adams, M., Collingwood, T. N., Provenzano, C., Browne P. O., Rajanayagam, O., Burris, T. P., Schwabe, J. W., Lazar, M. A. and Chatterjee, V. K., A dominant-negative peroxisome proliferator-activated receptor γ (PPARγ) mutant is a constitutive repressor and inhibits PPARγ-mediated adipogenesis. J. Biol. Chem. 2000. 275: 5754-5759.
35. 2+. Am. J. Physiol. Cell. Physiol. 2000. 278: 1116-1125.
36. Vosseler, C. A., Erl, W. and Weber, P. C., Structural requirements of cyclopentenone prostaglandins to induce endothelial cell apoptosis. Biochem. Biophys. Res. Commun. 2003. 307: 322-326.
37. Erl, W., Hristov, M., Neureuter, M., Yan, Z. Q., Hansson, G. K. and Weber, P. C., HMG-CoA reductase inhibitors induce apoptosis in neointima-derived vascular smooth muscle cells. Atherosclerosis 2003. 169: 251-258.
38. Erl, W., Hansson, G. K., de Martin, R., Draude, G., Weber, K. S. and Weber, C., NF-κB regulates induction of apoptosis and inhibitor of apoptosis protein-1 expression in vascular smooth muscle cells. Circ. Res. 1999. 84: 668-677.
39. von Knethen, A. and Brüne, B., Activation of peroxisome proliferator-activated receptor γ by nitric oxide in monocytes/macrophages down-regulates p47phox and attenuates the respiratory burst. J. Immunol. 2002. 169: 2619-2626.